Abstract Sustained release matrix tablets of 100 mg losartan potassium HCl were fabricated with two
release retarding polymers namely HPMC K100 M and affinisol by direct compression method.
Nine trial formulations were prepared by varying content of these polymers, each from 50 mg
to 100 mg; keeping the...
Abstract In the work the andrographolide (AG)-solid dispersions (SDs) were prepared by the spray-drying method, using polyethylene glycol 8000 (PEG8000), Poloxamer188, polyvinylpyrrolidone K30 (PVPK30), Soluplus® as carrier materials. The effect of different polymers as carrier materials on the properti...
Abstract Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions. Many dissolution media described in pharmacopoeias are no...
Abstract This work aims to ascertain the comprehensiveness of dissolution tests for oral suspensions registered in Brazil and the USA. After consulting literature since 1994, a paucity of information about dissolution methods for suspensions was detected. It makes it difficult to establish the most appro...
In this study, a dichloromethane fraction dry extract from the underground parts of Jatropha isabellei (DFJi) was used to prepare lipid nanocarriers (LNCJi) aimed at providing the oral delivery of terpenic compounds in the treatment of arthritis. The lipid nanocarriers were prepared by the spontaneous em...
The aim of this work was to assess if the commercially available Fluconazole drug products (Reference, Generic and Similar) would meet the biowaiver criteria from Food and Drug Administration (FDA) and Brazilian Agency for Health Surveillance (ANVISA) agencies. All formulations were evaluated considering...
Abstract Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of systemic mycoses. After oral administration o...
Disolución,
Administración Oral,
Cristalización/instrumentación,
Disponibilidad Biológica,
Eficiencia,
Espectroscopía Infrarroja por Transformada de Fourier,
Esguinces y Distensiones/diagnóstico,
Levaduras/clasificación,
Micosis/patología,
Preparaciones Farmacéuticas,
Técnicas In Vitro/métodos,
Ácido Clorhídrico
Abstract The current investigation was used to improve the rate of dissolution of an anti-diarrheal drug i.e., racecadotril (RT) at low pH conditions (i.e., in the stomach) by reducing the water secretion and electrolyte in to the intestine by liquisolid tablets. Different formulations (liquisolid) were ...
A baixa solubilidade aquosa dos insumos farmacêuticos ativos (IFA) é um grande desafio no desenvolvimento de formulações farmacêuticas, pois pode resultar em biodisponibilidade insuficiente e variável. Diversas estratégias de modificação do estado sólido dos compostos ativos, têm sido proposta...
Poloxámero/análogos & derivados,
Insumos Farmacéuticos,
Análisis Espectral/instrumentación,
Análisis de Fourier,
ADN Polimerasa Dirigida por ARN/efectos adversos,
Derivados de la Hipromelosa/metabolismo,
Disolución,
Espectroscopía Infrarroja por Transformada de Fourier,
Preparaciones Farmacéuticas/administración & dosificación,
Terapia Antirretroviral Altamente Activa/instrumentación,
Rastreo Diferencial de Calorimetría/métodos
Avaliar, por microscopia eletrônica de varredura (MEV), o efeito do uso individual e combinado do etidronato 18% (HEBP) na remoção da smear layer do canal radicular. Métodos: Trinta dentes humanos unirradiculares foram utilizados. As raízes foram preparadas com instrumentos rotatórios do Sistema Pr...
