LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Equilibrium solubility versus intrinsic dissolution: characterization of lamivudine, stavudine and zidovudine for BCS classification

Dezani, André Bersani; Pereira, Thaisa Marinho; Caffaro, Arthur Massabki; Reis, Juliana Mazza; Serra, Cristina Helena dos Reis.

Braz. j. pharm. sci; 49 (4), 2013

Solubility and dissolution rate of drugs are of major importance in pre-formulation studies of pharmaceutical dosage forms. The solubility improvement allows the drugs to be potential biowaiver candidates and may be a good way to develop more dose-efficient formulations. Solubility behaviour of lamivudin...

Preparaciones Farmacéuticas/análisis, Disolución, Biofarmacia/clasificación, Disolución/clasificación, Solubilidad

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Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of nifedipine-betacyclodextrin complexes

Jagdale, Swati Changdeo; Jadhav, Vinayak Narhari; Chabukswar, Aniruddha Rajaram; Kuchekar, Bhanudas Shankar.

Braz. j. pharm. sci; 48 (1), 2012

The main objective of the study was to enhance the dissolution of nifedipine, a poorly water soluble drug by betacyclodextrin complexation and to study the effect of the preparation method on the in vitro dissolution profile. The stoichiometric ratio determined by phase solubility analysis for inclusion ...

Comprimidos/análisis, Solubilidad, 24965/clasificación, Química Farmacéutica/métodos, Nifedipino/análisis, beta-Ciclodextrinas/análisis, Disolución/clasificación

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Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process

Issa, Michele Georges; Pessole, Letícia; Takahashi, Andrea Ikeda; Andréo Filho, Newton; Ferraz, Humberto Gomes.

Braz. j. pharm. sci; 48 (3), 2012

With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated the...

24965/análisis, Disolución/clasificación, Ligandos, Polímeros/clasificación, Implantes de Medicamentos

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Enhancing the aqueous solubility and dissolution of olanzapine using freeze-drying

Dixit, Mudit; Kini, Ashwini Gopalkrishna; Kulkarni, Parthasarthi Keshavarao.

Braz. j. pharm. sci; 47 (4), 2011

The aim of the present study was to develop an olanzapine freeze-dried tablet (FDT). The solubility and dissolution rate of poorly water-soluble olanzapine was improved by preparing a freeze-dried tablet of olanzapine using the freeze-drying technique . The FDT was prepared by dispersing the drug in an a...

Antipsicóticos/farmacocinética, Solubilidad, Disolución/clasificación, Congelación, Liofilización/22074

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