Rojas, Juan Ignacio;
Patrucco, Liliana;
Fruns, Manuel;
Hornung, Giesela;
Flores, José;
Carnero Contentti, Edgar;
Lopez, Pablo Adrian;
Pettinicchi, Juan Pablo;
Caride, Alejandro;
Galleguillos, Lorna;
Barahona, Jorge;
Diaz, Violeta;
Hernández, Marianella;
Alonso, Ricardo;
Cristiano, Edgardo.
ABSTRACT Background: Despite the abundance of information concerning ocrelizumab in phase III clinical trials, there is scarce evidence regarding real-world patient profiles. Objective: The aim of this study was to investigate patient profiles, effectiveness and persistence with treatment among patie...
Objetivo: Avaliar o impacto orçamentário da inclusão da cladribina oral no tratamento de esclerose múltipla remitente-recorrente em alta atividade da doença (EMRR HDA) no Sistema de Saúde Suplementar (SSS). Métodos: Foi conduzida uma análise de impacto orçamentário, sob a perspectiva do SSS, co...
ABSTRACT Introduction: Magnetic resonance imaging (MRI) is the most important tool for diagnosis and follow-up in multiple sclerosis (MS). The discrimination of relapsing-remitting MS (RRMS) from secondary progressive MS (SPMS) is clinically difficult, and developing the proposal presented in this stud...
ABSTRACT Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D r...
Enfermedades del Sistema Nervioso Autónomo/sangre,
Enfermedades del Sistema Nervioso Autónomo/fisiopatología,
Presión Sanguínea/fisiología,
Estudios de Casos y Controles,
Estudios Transversales,
Ensayo de Inmunoadsorción Enzimática,
Frecuencia Cardíaca/fisiología,
Hipertensión/sangre,
Hipertensión/fisiopatología,
Hipotensión Ortostática/sangre,
Hipotensión Ortostática/fisiopatología,
Esclerosis Múltiple Recurrente-Remitente/sangre,
Esclerosis Múltiple Recurrente-Remitente/fisiopatología,
Disautonomías Primarias/sangre,
Disautonomías Primarias/etiología,
Disautonomías Primarias/fisiopatología,
Receptores de Calcitriol/sangre,
Valores de Referencia,
Factores de Riesgo,
Estadísticas no Paramétricas,
Posición Supina/fisiología,
Vitamina D/sangre,
Deficiencia de Vitamina D/sangre,
Deficiencia de Vitamina D/complicaciones,
Proteína de Unión a Vitamina D/sangre
ABSTRACT Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system. Its treatment has focused on inflammation control as early as possible to avoid disability. Autologous hematopoietic stem cell transplantation (AHSCT) has been used for treating MS since 1996, with recent decisi...
La esclerosis múltiple remitente-recurrente (EM-RR) es una enfermedad desmielinizante del sistema nervioso central. A fin de entender la asociación del estrés oxidativo a nivel periférico con la recaída de la enfermedad se determinaron los niveles de marcadores de estrés oxidativo en plasma de paci...
ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting ...
Evaluación de la Discapacidad,
Fatiga/complicaciones,
Fatiga/fisiopatología,
Interleucina-6/sangre,
Presiones Respiratorias Máximas,
Esclerosis Múltiple Recurrente-Remitente/complicaciones,
Esclerosis Múltiple Recurrente-Remitente/fisiopatología,
Análisis Multivariante,
Fatiga Muscular/fisiología,
Escalas de Valoración Psiquiátrica,
Calidad de Vida,
Respiración,
Índice de Severidad de la Enfermedad,
Estadísticas no Paramétricas,
Factor de Necrosis Tumoral alfa/sangre
ABSTRACT Objective: To determine the prevalence of bruxism and related factors in patients with multiple sclerosis (MS). Methods: Diagnosed with relapsing-remitting MS under the 2010-revised McDonald diagnostic criteria, 182 patients without MS exacerbations during the previous three months were includ...
Edad de Inicio,
Bruxismo/epidemiología,
Bruxismo/etiología,
Bruxismo/fisiopatología,
Estudios de Casos y Controles,
Evaluación de la Discapacidad,
Esclerosis Múltiple Recurrente-Remitente/complicaciones,
Esclerosis Múltiple Recurrente-Remitente/epidemiología,
Esclerosis Múltiple Recurrente-Remitente/fisiopatología,
Prevalencia,
Índice de Severidad de la Enfermedad,
Factores Socioeconómicos,
Estadísticas no Paramétricas,
Brote de los Síntomas,
Turquía/epidemiología
ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginni...
Alelos,
Progresión de la Enfermedad,
Frecuencia de los Genes/genética,
Predisposición Genética a la Enfermedad,
Genotipo,
Antígenos HLA/genética,
Antígenos HLA-D/genética,
Inmunosupresores/uso terapéutico,
Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico,
Esclerosis Múltiple Recurrente-Remitente/genética,
Índice de Severidad de la Enfermedad,
Factores de Tiempo,
Resultado del Tratamiento
Boa, Izadora Nogueira Fonte;
Rimkus, Carolina de Medeiros;
Campanholo, Kenia Repiso;
Pereira, Samira Luisa Apóstolos;
Junqueira, Thiago de Faria;
Machado, Melissa de Almeida Rodrigues;
Callegaro, Dagoberto;
Otaduy, Maria Concepción García;
Leite, Claudia da Costa;
Miotto, Eliane Correa.
ABSTRACT Objective: A 4.5-year follow-up study was conducted to characterize baseline verbal episodic memory (VEM) and its behavior and to assess the effects of relapsing-remitting multiple sclerosis (RRMS) on this domain. Methods: Twenty-nine patients with RRMS underwent two neuropsychological assessm...
