Results: 723

Eucommia granules activate Wnt/β-catenin pathway, and improve oxidative stress, inflammation, and endothelial injury in preeclampsia rats

Acta cir. bras; 39 (), 2024
Purpose: Pre-eclampsia (PE) is a pregnancy-related complication. Eucommia is effective in the treatment of hypertensive disorders in pregnancy, but the specific effects and possible mechanisms of Eucommia granules (EG) in PE remain unknown. The aim of this study was to investigate the effects and possibl...

XinJiaCongRongTuSiZiWan protects triptolide-induced rats from oxidative stress injury via mitophagy mediated PINK1/Parkin signaling pathway

Acta cir. bras; 39 (), 2024
Purpose: XinJiaCongRongTuSiZiWan (XJCRTSZW) is a traditional Chinese medicine compound for invigorating the kidney, nourishing blood, and promoting blood circulation. This study aimed to explore the effect of XJCRTSZW on triptolide (TP)-induced oxidative stress injury. Methods: Adult female Sprague-Dawle...

Columbianadin ameliorates experimental acute reflux esophagitis in rats via suppression of NF-κB pathway

Acta cir. bras; 39 (), 2024
Purpose: Reflux esophagitis is a condition characterized by inflammation and irritation of the esophagus, resulting from the backflow of stomach acid and other gastric contents into the esophagus. Columbianadin is a coumarin derivative that exhibits anti-inflammatory and antioxidant effects. In this stud...

Effects of vitamin D supplementation on oxidative stress biomarkers of Iranian women with polycystic ovary syndrome: a meta-analysis study

Abstract Objective To identify the impact of redox imbalance on the clinical evolution of patients with polycystic ovary syndrome and carry out a qualitative and quantitative projection of the benefits of vitamin D supplementation. Data sources Combinations of the keywords polycystic ovary syndrome, ...

Is there a difference in the oxidative stress levels between type 2 diabetic individuals with and without periodontitis? Systematic review

Braz. dent. sci; 27 (2), 2024
Objective: The authors’ aim in this systematic review was to verify the scientific evidence for difference of oxidative stress biomarkers in individuals with type 2 diabetes mellitus with and without periodontitis. Material and Methods: Observational studies, baseline data of prospective and interventi...

Bioatividade de compostos da pele de amendoim (Arachis hypogaea L. ): inibição enzimática, inibição do crescimento celular, estresse oxidativo e apoptose em células de câncer colorretal, HCT-116

O câncer colorretal (CCR) é a segunda maior causa de morte por câncer no mundo. Os efeitos colaterais das terapias convencionais, normalmente agressivos, são comuns em todos os tratamentos indicados aos cânceres. O objetivo deste estudo foi avaliar os efeitos de fitoquímicos extraídos da pele de a...

Neuroprotective effects of the combined treatment of resveratrol and urapidil in experimental cerebral ischemia-reperfusion injury in rats

Acta cir. bras; 39 (), 2024
Purpose: To evaluate the neuroprotective effect of resveratrol, urapidil, and a combined administration of these drugs against middle cerebral artery occlusion (MCAO) induced ischemia/reperfusion (IR) injury model in rats. Methods: Thirty-five rats were divided into five groups of seven animals each. Ani...

Amorphophallus campanulatus tuber extract protects diabetic nephropathy in streptozotocin-induced diabetic nephropathy rat model by regulating oxidative stress and TNF-α inflammatory pathway

Acta cir. bras; 39 (), 2024
Purpose: To assess the effect of Amorphophallus campanulatus tuber (Ac) extract in the protection of diabetic nephropathy in streptozotocin (STZ) induced diabetic nephropathy (DN) rat model. Methods: Diabetes was induced with STZ (60 mg/kg, i.p.), and DN was confirmed after six weeks of STZ administrati...

Dietary total antioxidant capacity, cardiovascular risk, and anthropometric obesity indices in hemodialysis patients: A case-control study

Rev. Nutr. (Online); 37 (), 2024
ABSTRACT Objective: Oxidative stress is triggered by malnutrition and antioxidant losses due to dialysis in hemodialysis patients and thus, oxidative stress increases the risk of mortality in patients with cardiovascular disease and obesity. The study aims to determine differences in cardiovascular risk...

Genética y genómica de la longevidad y el envejecimiento
Genetics and genomics of longevity and aging

Cambios rev. méd; 22 (2), 2023; 22 (2), 2023; 22 (2), 2023
El envejecimiento y la longevidad son procesos que involucran una serie de factores genéticos, bioquímicos y ambientales. En esta revisión se tratan algunas cuestiones sobre estos dos procesos biológicos y epigenéticos. Se presentan los genes más importantes en estos procesos, así como se ejemplif...