Diabetes mellitus is associated with neural and micro- and macrovascular complications. Therapeutic options for these complications are limited and the delivery of mesenchymal stem cells into lesions have been reported to improve the healing process. In this work, the effects of the administration of a l...
Medeiros, Scheila;
Maia, Thayná Patachini;
Lima, Aline Barbosa;
Pscheidt, Luana Carla;
Delmonego, Larissa;
Vincenzi, Karine Louize;
Custodio, Bruna Vanzin;
Dal Magro, Débora Delwing;
Barauna, Sara Cristiane;
Alberton, Michele Debiasi;
Pereira, Eduardo Manoel;
Delwing-de Lima, Daniela.
We investigated the effects of dichloromethane extract (DME) from Myrcia splendenson alterations caused by type 2 diabetes in the blood and kidney of rats, in order to reduce side effects caused by synthetic drugs. Rats received streptozotocin (60 mg/kg),15 minutes after nicotinamide (120 mg/kg) or water...
Myrtaceae/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Extractos Vegetales/administración & dosificación,
Cloruro de Metileno/administración & dosificación,
Hipolipemiantes/administración & dosificación,
Hipoglucemiantes/administración & dosificación,
Antioxidantes/administración & dosificación,
Extractos Vegetales/química,
Compuestos Fenólicos/análisis,
Estrés Oxidativo/efectos de los fármacos,
Cromatografía Líquida de Alta Presión,
Espectrometría de Masa por Ionización de Electrospray,
Ratas Wistar,
Glucemia/efectos de los fármacos,
Estreptozocina
Abstract Objective: To investigate the differences of receptor activator of nuclear factor-κB ligand (RANKL) and Osteoprotegerin (OPG) expressions between normoglycemic and hyperglycemic Wistar rats (Rattus Novergicus) during Orthodontic Tooth Movement (OTM). Material and Methods: This study was t...
Técnicas de Investigación,
Análisis de Varianza,
Ratas Wistar,
Técnicas de Movimiento Dental,
Osteoprotegerina,
Inmunohistoquímica,
Diente Molar,
28573,
Diabetes Mellitus,
Hiperglucemia,
Estreptozocina,
Ligando RANK
IntroductionDiabetes Mellitusis an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathic system of medicine uses ultra-molecular doses for treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes,nosodes an...
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear...
There is emerging evidence for a dysregulation of insulin signaling in the brains of patients with Alzheimer's disease (AD) with overlapping molecular features to Type 2 Diabetes Mellitus (T2DM). In addition, T2DM is a known risk factor of AD. The goal of this study was to investigate the neurogenic and ...
Cnidoscolus chayamansa is a native plant of the Mayan region, which is also cultivated in other places like northern Mexico, Tunisia and India. Many properties are attributed to Mayan Chaya, such as aid in the control of glycemia in diabetics. Thus this study aimed to evaluate the hypoglycemic effects of...
Abstract Purpose To explore the role of all-trans retinoic acid (ATRA) in renal ischemia/reperfusion injury of diabetic rats. Methods Sixty adult male rats were randomly divided into 6 groups, including sham group (S group), ischemia-reperfusion group (I/R group), ischemia-reperfusion+ATRA group (A g...
Diabetes Mellitus Experimental/inducido químicamente,
Modelos Animales de Enfermedad,
Evaluación Preclínica de Medicamentos,
Riñón/efectos de los fármacos,
Riñón/patología,
Factor 2 Relacionado con NF-E2/farmacología,
Factor 2 Relacionado con NF-E2/uso terapéutico,
Daño por Reperfusión/patología,
Daño por Reperfusión/prevención & control,
Estreptozocina,
Tretinoina/farmacología,
Tretinoina/uso terapéutico
Abstract Purpose: To investigate whether GDF11 ameliorates myocardial ischemia reperfusion (MIR) injury in diabetic rats and explore the underlying mechanisms. Methods: Diabetic and non-diabetic rats subjected to MIR (30 min of coronary artery occlusion followed by 120 min of reperfusion) with/without ...
Antioxidantes/farmacología,
Autofagia/efectos de los fármacos,
Western Blotting,
Cardiotónicos/farmacología,
Línea Celular,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Tipo 1/metabolismo,
Factores de Diferenciación de Crecimiento/farmacología,
Hemodinámica/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Daño por Reperfusión Miocárdica/tratamiento farmacológico,
Daño por Reperfusión Miocárdica/metabolismo,
Daño por Reperfusión Miocárdica/patología,
Estrés Oxidativo/efectos de los fármacos,
Ratas Sprague-Dawley,
Valores de Referencia,
Reproducibilidad de los Resultados,
Estreptozocina,
Superóxido Dismutasa/análisis,
Regulación hacia Arriba/efectos de los fármacos
Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eight...
Albuminuria/tratamiento farmacológico,
Glucemia,
Creatinina/sangre,
Creatinina/orina,
Diabetes Mellitus Experimental/sangre,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/patología,
Diabetes Mellitus Experimental/orina,
Nefropatías Diabéticas/sangre,
Nefropatías Diabéticas/terapia,
Nefropatías Diabéticas/patología,
Nefropatías Diabéticas/orina,
Modelos Animales de Enfermedad,
Glicosaminoglicanos/orina,
Oxidorreductasas Intramoleculares/antagonistas & inhibidores,
Riñón/patología,
Activación de Macrófagos,
Factores Inhibidores de la Migración de Macrófagos/antagonistas & inhibidores,
Sustancias Protectoras/farmacología,
Sustancias Protectoras/uso terapéutico,
Ratas Wistar,
Estreptozocina/farmacología
