La aparición de nódulos tiroideos en las personas con acromegalia es una consecuencia de la elevación crónica de la hormona de crecimiento y el factor de crecimiento similar a la insulina tipo 1. Su naturaleza varía según la zona geográfica, suficiencia de yodo y antecedentes patológicos familiar...
The objective of this study was to evaluate the rate of conception, metabolic, and structural conditions of cryopreserved bovine sperm cells, plus extender with IGF-1 and glutathione (GSH). 12 ejaculations of Nelore bulls were used, submitted to treatments: control, gSH (2mM/mL), IGF-1 (100ng/mL) and gSH...
Abstract Background: IGF-1 may be an important factor in bone remodeling, but its mechanism of action on osteoclasts during orthodontic tooth movement is complex and unclear. Methodology: The closed-coil spring was placed between the left maxillary first molar and upper incisors with a force of 50 g to e...
Objetivou-se avaliar a condição metabólica e estrutural das células espermáticas bovinas após congelação, com adição prévia de IGF-I e insulina no meio diluidor seminal. Os ejaculados de seis touros Nelore foram submetidos a quatro tratamentos: controle; insulina (100µUI/mL); IGF-I (150ng/mL)...
Insulin-like growth factor-1 (IGF-1) is regarded as a crucial clinically significant therapeutic agent against several pathological conditions. Recently, recombinant DNA (rDNA) technology has enabled the production of many drugs of rDNA-origin including IGF-1. Securing a readily available supply of IGF-1...
ABSTRACT Objective The insulin tolerance test (ITT) has been accepted as the gold standard test for assessing the integrity of the growth hormone (GH) - insulin-like growth factor (IGF-1) axis and the hypothalamic-pituitary-adrenal (HPA) axis. The goal of the test is to achieve clinical and biochemical...
Automonitorización de la Glucosa Sanguínea,
Prueba de Tolerancia a la Glucosa/efectos adversos,
Prueba de Tolerancia a la Glucosa/métodos,
Hormona de Crecimiento Humana/sangre,
Hidrocortisona/sangre,
Hipoglucemia/sangre,
Hipoglucemia/diagnóstico,
Hipoglucemia/metabolismo,
Hipoglucemiantes/administración & dosificación,
Sistema Hipotálamo-Hipofisario/metabolismo,
Insulina/administración & dosificación,
Factor I del Crecimiento Similar a la Insulina/análisis,
Sistema Hipófiso-Suprarrenal/metabolismo,
Estudios Retrospectivos
Abstract Menopause induces oral bone loss, leading to various oral diseases. Mastication importantly affects bone metabolism in the jawbone. Objective: To analyze the effect of enhanced masticatory force on osteoprotegerin (OPG), receptor activator of nuclear factor kappa B ligand (RANKL), and mechano-g...
Fosfatasa Alcalina/sangre,
Proceso Alveolar/fisiopatología,
Fuerza de la Mordida,
Western Blotting,
Ensayo de Immunospot Ligado a Enzimas,
Estradiol/sangre,
Factor I del Crecimiento Similar a la Insulina/análisis,
Osteocalcina/sangre,
Osteoprotegerina/análisis,
Ovariectomía,
Ligando RANK/análisis,
Ratas Sprague-Dawley,
Reacción en Cadena de la Polimerasa,
Microtomografía por Rayos X
ABSTRACT In addition to auxiological, clinical and metabolic features measurements of growth hormone (GH) and insulin-like growth factor I (IGF-I) complement our tools in diagnosis and follow-up of GH-related disorders. While comparably robust during the pre-analytical phase, measurement and interpretati...
ABSTRACT The somatotropic axis is the main hormonal regulator of growth. Growth hormone (GH), also known as somatotropin, and insulin-like growth factor 1 (IGF-1) are the key components of the somatotropic axis. This axis has been studied for a long time and the knowledge of how some molecules could prom...
Boguszewski, Cesar L;
Huayllas, Martha Katherine P;
Vilar, Lucio;
Naves, Luciana Ansaneli;
Ribeiro-Oliveira Junior, Antonio;
Soares, Beatriz Santana;
Czepielewski, Mauro Antonio;
Abucham, Julio;
Correa-Silva, Silvia Regina;
Bronstein, Marcello Delano;
Jallad, Raquel Soares;
Duarte, Felipe Gaia;
Musolino, Nina Rosa;
Kasuki, Leandro;
Gadelha, Monica Roberto.
ABSTRACT Objective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients wi...
Acromegalia/tratamiento farmacológico,
Adenoma/tratamiento farmacológico,
Glucemia/análisis,
Brasil,
Cabergolina/administración & dosificación,
Cabergolina/uso terapéutico,
Quimioterapia Combinada,
Hormona del Crecimiento/sangre,
Hormona de Crecimiento Humana/análogos & derivados,
Factor I del Crecimiento Similar a la Insulina/análisis,
Valor Predictivo de las Pruebas,
Receptores de Somatostatina/uso terapéutico,
Resultado del Tratamiento
