ABSTRACT OBJECTIVE Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí. METHODS Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as ...
Accidentes por Caídas,
Envejecimiento,
Biomarcadores/sangre,
Índice de Masa Corporal,
Brasil,
Quimiocinas/sangre,
Escolaridad,
Interleucinas/sangre,
Persona de Mediana Edad,
Estado Nutricional,
Reacción en Cadena de la Polimerasa,
Estudios Prospectivos,
Factores de Riesgo,
Factor de Necrosis Tumoral alfa/sangre
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and ...
Trastorno Depresivo/tratamiento farmacológico,
Trastorno Depresivo/metabolismo,
Trastorno Depresivo/psicología,
Modelos Animales de Enfermedad,
Flavonoides/administración & dosificación,
Suspensión Trasera/psicología,
Interleucina-1beta/sangre,
Interleucina-6/sangre,
Ratones Endogámicos C57BL,
Estrés Oxidativo/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/sangre
OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusiv...
Activinas/sangre,
Activinas/metabolismo,
Índice de Masa Corporal,
Caquexia/metabolismo,
Estudios de Casos y Controles,
Subunidades beta de Inhibinas,
Músculo Esquelético/fisiopatología,
Atrofia Muscular/sangre,
Atrofia Muscular/etiología,
Atrofia Muscular/metabolismo,
Enfermedad Pulmonar Obstructiva Crónica/sangre,
Enfermedad Pulmonar Obstructiva Crónica/complicaciones,
Factor de Necrosis Tumoral alfa/sangre,
Factor de Necrosis Tumoral alfa/metabolismo
Milan-Mattos, J C;
Anibal, F F;
Perseguini, N M;
Minatel, V;
Rehder-Santos, P;
Castro, C A;
Vasilceac, F A;
Mattiello, S M;
Faccioli, L H;
Catai, A M.
The term inflammaging is now widely used to designate the inflammatory process of natural aging. During this process, cytokine balance is altered, presumably due to the loss of homeostasis, thus contributing to a greater predisposition to disease and exacerbation of chronic diseases. The aim of the study...
Factores de Edad,
Envejecimiento/fisiología,
Biomarcadores/análisis,
Proteína C-Reactiva/análisis,
Colesterol/sangre,
Inmunosenescencia/fisiología,
Inflamación/sangre,
Interleucina-6/sangre,
Consumo de Oxígeno/fisiología,
Factores Sexuales,
Triglicéridos/sangre,
Factor de Necrosis Tumoral alfa/sangre
Abstract: This study aimed to investigate the effects of astragaloside IV (AsIV) on inflammation and immunity in rats with experimental periodontitis. Periodontitis was established in 48 Wistar rats, which were then randomly divided into model and 10, 20 and 40 mg/kg AsIV groups, with 12 rats in each gro...
Sistema Inmunológico/efectos de los fármacos,
Inmunoglobulinas/sangre,
Interleucina-1beta/sangre,
Interleucina-2/sangre,
Periodontitis/tratamiento farmacológico,
Periodontitis/inmunología,
Periodontitis/patología,
Distribución Aleatoria,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Saponinas/farmacología,
Subgrupos de Linfocitos T,
Movilidad Dentaria,
Resultado del Tratamiento,
Triterpenos/farmacología,
Factor de Necrosis Tumoral alfa/sangre
Abstract Purpose To investigate the effect of sevoflurane preconditioning on ischemia/reperfusion (I/R)-induced pulmonary/hepatic injury Methods Fifty-one Wistar rats were randomly grouped into sham, I/R, and sevoflurane groups. After reperfusion, the structural change of the lung was measured by Smi...
Alanina Transaminasa/sangre,
Anestésicos por Inhalación/uso terapéutico,
Aspartato Aminotransferasas/sangre,
Modelos Animales de Enfermedad,
Isquemia/prevención & control,
Precondicionamiento Isquémico/métodos,
Hígado/irrigación sanguínea,
Hígado/efectos de los fármacos,
Hígado/patología,
Pulmón/irrigación sanguínea,
Pulmón/efectos de los fármacos,
Pulmón/patología,
Malondialdehído/análisis,
Peroxidasa/análisis,
Daño por Reperfusión/tratamiento farmacológico,
Daño por Reperfusión/prevención & control,
Sevoflurano/uso terapéutico,
Factor de Necrosis Tumoral alfa/sangre
Jang, Ji Su;
Lee, Yeon-Hee;
Kandahar, Hemant K;
Shrestha, Suman K;
Lee, Jae Sung;
Lee, Jin-Koo;
Park, Seung Jae;
Lee, Na Rea;
Lee, Jae Jun;
Lee, Sang-Soo.
Abstract Background and objectives: An ultrasound guided femoral nerve block is an established analgesic method in patients with a hip fracture. Elevated cytokine levels correlate with poor patient outcomes after surgery. Hence, the aim of the study was to describe the levels of tumor necrosis factor-&#...
Abstract Purpose: To investigate the effect of oxymatrine on periodontitis in rats and related mechanism. Methods: Ninety SD rats were divided into control, model, 10, 20 and 40 mg/kg oxymatrine and tinidazole groups. The periodontitis model was established in later 5 groups. The 10, 20 and 40 mg/kg oxy...
Alcaloides/farmacología,
Antiinflamatorios/farmacología,
Índice de Placa Dental,
Dinoprostona/sangre,
Encía/patología,
Interleucina-1beta/sangre,
Metaloproteinasas de la Matriz/análisis,
Metaloproteinasas de la Matriz/efectos de los fármacos,
Periodontitis/tratamiento farmacológico,
Periodontitis/metabolismo,
Quinolizinas/farmacología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Valores de Referencia,
Reproducibilidad de los Resultados,
Tinidazol,
Inhibidores Tisulares de Metaloproteinasas/análisis,
Inhibidores Tisulares de Metaloproteinasas/efectos de los fármacos,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/sangre
SUMMARY OBJECTIVE: We conducted this study to investigate the clinical efficacy of endoscopic retrograde cholangiopancreatography (ERCP) on elder choledocholithiasis and its effects on the levels of TNF-α, IL-1, and IL-6. METHODS: Elder patients with choledocholithiasis were enrolled in this study...
Colangiopancreatografia Retrógrada Endoscópica,
Coledocolitiasis/sangre,
Coledocolitiasis/diagnóstico por imagen,
Coledocolitiasis/cirugía,
Conducto Colédoco/cirugía,
Interleucina-1/sangre,
Interleucina-6/sangre,
Tiempo de Internación,
Persona de Mediana Edad,
Periodo Posoperatorio,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/sangre
ABSTRACT Objective: To observe the effect of thymosin alpha l (Tα1) on severe acute pancreatitis (SAP) in rats. Methods: Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups (eight in each group): control group (Group A), SAP group (Group B) and Tα1 treatment gro...
Modelos Animales de Enfermedad,
Pancreatitis/tratamiento farmacológico,
Índice de Severidad de la Enfermedad,
Enfermedad Aguda,
Timalfasina/administración & dosificación,
Adyuvantes Inmunológicos/administración & dosificación,
Ratas Sprague-Dawley,
Biomarcadores/sangre,
Factor de Necrosis Tumoral alfa/sangre,
Interleucinas/sangre,
Amilasas/sangre
