Background: CPEB is considered as an RNA-binding protein first identified in Xenopus oocytes. Although CPEB1 was involved in the growth of oocyte, its role in goat follicular granulosa cell has not been fully elucidated. To clarify the functions of this gene in goat follicular granulosa cells, CPEB1-over...
Cabras/genética,
Factores de Transcripción/genética,
Oocitos,
Células de la Granulosa,
Transferencia de Embrión,
Fertilización In Vitro,
Expresión Génica,
Proteínas de Unión al ARN,
Ganado,
Reacción en Cadena de la Polimerasa/métodos,
Transfección,
Western Blotting,
Fluorescencia
Introdução: A modulação do processo inflamatório por TLRs pode ser um fator chave no desenvolvimento e progressão tumoral, induzindo tanto a respostas pró-tumorais, como anti-tumorais, muitas vezes através da regulação da sinalização pela NF-B e subsequente produção de fatores de crescim...
Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T...
Enfermedad Aguda,
Proteína alfa Potenciadora de Unión a CCAAT/genética,
Citometría de Flujo,
Genotipo,
Haploinsuficiencia/genética,
Hematopoyesis/genética,
Leucemia Mieloide Aguda/genética,
Ratones Transgénicos,
Fenotipo,
Factores de Transcripción/genética,
Translocación Genética/genética
Human papillomavirus infection is associated with the development of malignant and benign neoplasms. Approximately 40 viral types can infect the anogenital mucosa and are categorized into high- and low-risk oncogenic human papillomavirus, depending on their association with the development of cervical ca...
OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patients in the Department of Gastrointestinal Oncology at Z...
Antineoplásicos/uso terapéutico,
Estudios de Casos y Controles,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/mortalidad,
Proteínas de Unión al ADN/genética,
Endonucleasas/genética,
Genotipo,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Proteínas Nucleares/genética,
Oxaliplatino/uso terapéutico,
Polimorfismo de Nucleótido Simple/genética,
Factores de Transcripción/genética
The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid...
Previous studies suggested that chromodomain helicase DNA-binding proteins (CHDs), including CHD 1-8, were associated with several human diseases and cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. To date, little research on CHD 9 in human cancers has been reported. In ...
Biomarcadores de Tumor/genética,
Biomarcadores de Tumor/metabolismo,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/metabolismo,
Neoplasias Colorrectales/patología,
ADN Helicasas,
Proteínas de Unión al ADN/genética,
Proteínas de Unión al ADN/metabolismo,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Pronóstico,
Transactivadores,
Factores de Transcripción/genética,
Factores de Transcripción/metabolismo
Abstract Introduction: Nasopharyngeal carcinoma is the most common cancer originating from the nasopharynx. Objective: To study the mechanisms of nasopharyngeal carcinoma, we analyzed GSE12452 microarray data. Methods: GSE12452 was downloaded from the Gene Expression Omnibus database and included 31 n...
Análisis de Varianza,
Carcinoma/genética,
Carcinoma/patología,
Quimiocina CXCL10/genética,
Quimiocina CXCL9/genética,
Análisis por Conglomerados,
Bases de Datos Genéticas,
Regulación hacia Abajo,
Perfilación de la Expresión Génica,
Expresión Génica,
Redes Reguladoras de Genes,
Análisis por Micromatrices,
Carcinoma Nasofaríngeo,
Neoplasias Nasofaríngeas/genética,
Neoplasias Nasofaríngeas/patología,
Proteínas Nucleares/genética,
Factores de Transcripción/genética,
Regulación hacia Arriba
Background: Streptomyces clavuligerus was the producer of clavulanic acid, claR, a pathway-specific transcriptional regulator in S. clavuligerus, positively regulates clavulanic acid biosynthesis. In this study, the promoter-less kanamycin resistance gene neo was fused with claR to obtain strain NEO from...
Streptomyces/metabolismo,
Ácido Clavulánico/biosíntesis,
Mutagénesis,
Fermentación,
Genes Reporteros,
Regiones Promotoras Genéticas,
Transcripción Genética,
Streptomyces/genética,
Bioensayo,
Cromatografía Líquida de Alta Presión,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Fusión Génica,
Kanamicina,
Proteínas Recombinantes,
Factores de Transcripción/genética
Resumo A síndrome tricorrinofalangiana (STRF) tipo I é uma doença genética rara, relacionada com a mutação no gene TRPS1 do cromossomo 8. É caracterizada por anomalias craniofaciais e distúrbios na formação e maturação da matriz óssea. As características são cabelos ralos e quebradiços, t...
Artralgia/etiología,
Artralgia/genética,
Falanges de los Dedos de la Mano/anomalías,
Dedos/anomalías,
Dedos/fisiopatología,
Enfermedades del Cabello/diagnóstico,
Enfermedades del Cabello/genética,
Enfermedades del Cabello/fisiopatología,
Síndrome de Langer-Giedion/diagnóstico,
Síndrome de Langer-Giedion/genética,
Síndrome de Langer-Giedion/fisiopatología,
Nariz/anomalías,
Nariz/fisiopatología,
Síndrome,
Factores de Transcripción/genética,
Proteínas de Unión al ADN/genética
