LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Extensive variation in drug-resistance mutational profile of Brazilian patients failing antiretroviral therapy in five large Brazilian cities

Brites, Carlos; Pinto-Neto, Lauro; Medeiros, Melissa; Nunes, Estevão; Sprinz, Eduardo; Carvalho, Mariana.

Braz. j. infect. dis; 20 (4), 2016

Abstract Background Development of drug-resistance mutations is the main cause of failure in antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients failing antiretroviral therapy. Objectives To define the HIV mutational profile associated with drug resistance ...

Fármacos Anti-VIH/farmacología, Terapia Antirretroviral Altamente Activa, Farmacorresistencia Viral/genética, Genotipo, Infecciones por VIH/virología, VIH-1/efectos de los fármacos, VIH-1/genética, Mutación/genética, Inhibidores de la Transcriptasa Inversa/farmacología, Carga Viral

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Monitoring the emergence of HBV resistance mutations by HBV-RNA pyrosequencing

Bottecchia, Marcelle; Barcaiu, Halime Silva; Lewis-Ximenez, Lia Laura; da Silva e Mouta Junior, Sergio; de Moraes, Marcia Terezinha Baroni.

Braz. j. infect. dis; 20 (2), 2016

Antivirales/farmacología, Farmacorresistencia Viral/genética, Virus de la Hepatitis B/efectos de los fármacos, Virus de la Hepatitis B/genética, Lamivudine/farmacología, Técnicas de Diagnóstico Molecular/métodos, Mutación/genética, ARN Viral/genética, ADN Polimerasa Dirigida por ARN/genética

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Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China

Zhao, Youyun; Wu, Jianhua; Sun, Lijun; Liu, Guangzhong; Li, Bo; Zheng, Yi; Li, Xiaodong; Tao, Junxiu.

Braz. j. infect. dis; 20 (2), 2016

Abstract Objective There are a lot of disagreements in the studies on hepatitis B virus (HBV) DNA polymerase mutation rate associated with nucleos(t)ide analogues (NAs) in treatment-naive chronic hepatitis B (CHB) patients. This is the first study aimed to investigate the prevalence of spontaneous HBV r...

Antivirales/uso terapéutico, China, ADN Viral/genética, ADN Polimerasa Dirigida por ADN/genética, Farmacorresistencia Viral/genética, Genotipo, Virus de la Hepatitis B/efectos de los fármacos, Virus de la Hepatitis B/genética, Hepatitis B Crónica/tratamiento farmacológico, Hepatitis B Crónica/virología, Mutación/genética, Prevalencia, Estudios Prospectivos

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