Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias
Säo Paulo med. j; 121 (2), 2003
CONTEXT: The p16 tumor suppressor gene encodes a cyclin-dependent kinase 4 inhibitor that blocks cell division during the G1 phase of the cell cycle. Alterations in this gene have been reported for various neoplasia types, including acute lymphoblastic leukemias (ALL), especially T-cell acute lymphoblast...