Results: 55

First genome sequence of Chilean Brucella canis SCL strain provides insights on the epidemiology and virulence factors, explaining differences between geographical origins

Electron J Biotechnol; 49 (), 2021
BACKGROUND: Brucella canis is the etiological agent of canine brucellosis, a worldwide neglected zoonosis that constitutes one of the major infectious causes of infertility and reproductive failure in dogs. Although genomic information available for this pathogen has increased in recent years, here we re...

O receptor aril de hidrocarbonetos (AhR) em melanomas: associação com mutações BRAF, com a progressão da doença e identificação de ligantes

O melanoma é um tipo de câncer de pele geneticamente diverso, que surge diante das transformações em melanócitos. A mutação BRAFV600E está presente em mais de 90% de todas as mutações em BRAF, sendo assim ocorre em cerca de 50% dos casos registrados. As mutações em NRAS, ocupam o segundo luga...

Bioinformática como recurso educativo para enseñar variabilidad genética mediante la comparación de mapas de restricción

Uno de los rasgos de la sociedad del siglo XXI es la incorporación de las TIC en la educación, las cuales pueden contribuir en los procesos de enseñanza-aprendizaje. Sin embargo, el maestro es quien le dá el sentido pedagógico a estos recursos educativos. En ese sentido, las herramientas de la bioin...

Genomics and epidemiology of the P 1 SARS-CoV-2 lineage in Manaus, Brazil

Science; 372 (6544), 2021
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SAR...

Genomic and transcriptomic characterization of the human glioblastoma cell line AHOL1

Braz. j. med. biol. res; 54 (3), 2021
Cancer cell lines are widely used as in vitro models of tumorigenesis, facilitating fundamental discoveries in cancer biology and translational medicine. Currently, there are few options for glioblastoma (GBM) treatment and limited in vitro models with accurate genomic and transcriptomic characterization...

Crispr, una herramienta para editar genomas

Gac. méd. boliv; 43 (2), 2020
El artículo se centra en la utilización de la nueva herramienta, CRISPR (repeticiones palindrómicas cortas agrupadas a intervalos regulares), la cual permite editar los genomas de los seres vivos de manera más precisa que otras técnicas; a lo largo del artículo se mencionan trabajos relacionados co...

Genome-wide development of polymorphic microsatellite markers and their application in peanut breeding program

BACKGROUND: Cultivated peanut (Arachis hypogaea. L) represents one of the most important oil crops in the world. Although much effort has been expended to characterize microsatellites or Simple Sequence Repeats (SSRs) in peanut, the quantity and quality of the markers in breeding applications remain limi...

Exploring the shared genes of hypertension, diabetes and hyperlipidemia based on microarray

Given their relationship with metabolic syndrome and systematic inflammatory diseases, the pathogenesis of hypertension, hyperglycemia, and hyperlipidemia is closely related. To explore the common genes among these three conditions, spontaneous hypertensive rats (SHR), spontaneous diabetic Goto-Kakizaki ...

De los guisantes de Mendel a la genómica de las cardiopatías familiares

Rev. colomb. cardiol; 25 (4), 2018
La Genética nació en el siglo XIX como una rama importante de la Biología gracias a las observaciones cuidadosas del monje checo Gregor Johann Mendel. Su trabajo no fue bien valorado entonces, a comienzos de 1865, cuando lo presentó en la Asociación de Historia Natural de Brno. El fundamento fue el ...

Papel do microbioma na resposta imune e na asma

Nos últimos vinte anos, passamos a reconhecer que o corpo humano hospeda, em condições normais, uma quantidade de microrganismos que supera o número de células do nosso organismo. A interação desses micróbios, seus genomas e seus metabolitos com nosso organismo desempenha papel relevante no desen...