LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid-induced acute lung injury in rats

Tan, Zelong; Wang, Huaizhou; Sun, Jing; Li, Mingsheng.

Acta cir. bras; 33 (3), 2018

Abstract Purpose: To investigate the effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid -induced acute lung injury in rats. Methods: A total of 32 male Sprague-Dawley rats (250-300g) were randomly divided into the following four groups (n=8/group): group...

Lesión Pulmonar Aguda/inducido químicamente, Lesión Pulmonar Aguda/tratamiento farmacológico, Lesión Pulmonar Aguda/metabolismo, Hemo-Oxigenasa 1/metabolismo, Inmunohistoquímica, Pulmón/efectos de los fármacos, Pulmón/enzimología, Pulmón/ultraestructura, Ácido Oléico, Propofol/farmacología, Distribución Aleatoria, Ratas Sprague-Dawley

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Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation

Zhang, Hongbin; Yuan, Bo; Huang, Hanfei; Qu, Siming; Yang, Shikun; Zeng, Zhong.

Braz. j. med. biol. res; 51 (10), 2018

Nuclear factor erythroid-related factor 2 (Nrf2) has been implicated in several detoxifying and antioxidant defense processes. Nrf2-mediated heme oxygenase-1 (HO-1) expression was demonstrated to play a key role against oxidative stress. Gastrodin (GSTD) is a well-known active compound isolated from the ...

Apoptosis/efectos de los fármacos, Alcoholes Bencílicos/farmacología, Supervivencia Celular/efectos de los fármacos, Células Endoteliales/efectos de los fármacos, Glucósidos/farmacología, Hemo-Oxigenasa 1/metabolismo, Peróxido de Hidrógeno/farmacología, Hígado/citología, Hígado/efectos de los fármacos, Malondialdehído/metabolismo, Modelos Teóricos, Regulación hacia Arriba/efectos de los fármacos, Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

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Effects of heme oxygenase-1 recombinant Lactococcus lactis on the intestinal barrier of hemorrhagic shock rats

Gao, XY; Zhou, XF; Wang, H; Lv, N; Liu, Y; Guo, JR.

Braz. j. med. biol. res; 50 (7), 2017

This study aimed to investigate the effects of heme oxygenase-1 recombinant Lactococcus lactis (LL-HO-1) on the intestinal barrier of rats with hemorrhagic shock. One hundred Sprague-Dawley male rats (280–320 g) were randomly divided into healthy control group (N group) and hemorrhagic shock group ...

Modelos Animales de Enfermedad, Hemo-Oxigenasa 1/uso terapéutico, Mucosa Intestinal/metabolismo, Mucosa Intestinal/patología, Lactococcus lactis, Distribución Aleatoria, Ratas Sprague-Dawley, Choque Hemorrágico/prevención & control

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O papel da heme oxigenase-1 na lesão celular desencadeada pelo sulfato de polimixina B em células LLC-PK 'K IND. 1'

Neiva, Luciana Barros de Moura.

A heme-oxigenase-1 (HO-1) é uma enzima induzível envolvida na degradação do grupo prostético heme, produzindo compostos com funções anti-oxidante, anti-inflamatória, anti-apoptótica e modulatória do sistema imune no rim. A importância de sua indução está associada à resposta adaptativa ao ...

Insuficiencia Renal/tratamiento farmacológico, Hemo-Oxigenasa 1, Polimixina B/toxicidad, Células LLC-PK1