Results: 12

Molecular cloning and antibacterial activity of hepcidin from Chinese rare minnow (Gobiocypris rarus)

Ke, Fei; Wang, Yun; Yang, Chuan-Shun; Xu, Chen.

Electron. j. biotechnol; 18 (3), 2015

Background Hepcidins, a kind of cysteine-rich antimicrobial peptides, play important roles in host immunological processes and iron regulation, which have been identified from several fish species. The rare minnow (Gobiocypris rarus), an endemic cyprinid fish in China, has been used extensively as model ...

Hepcidinas/química, Hepcidinas/genética, Antibacterianos/química, Clonación Molecular, Filogenia, ADN Complementario/genética, Cyprinidae, Cisteína, Análisis de Secuencia

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Sox2 function as a negative regulator to control HAMP expression

Song, Bin; Bian, Qi; Shao, Cheng-Hao; Liu, An-An; Jing, Wei; Liu, Rui; Zhang, Yi-Jie; Zhou, Ying-Qi; Li, Gang; Jin, Gang.

Biol. Res; 48 (), 2015

BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores. Abnormal levels of HAMP expression alter plasma iron parameters and lead to iron metabolism disorders. Therefore,itis animpo...

Regulación Neoplásica de la Expresión Génica/genética, Hepatocitos/metabolismo, Hepcidinas/genética, Factores de Transcripción SOXB1/genética, Anemia/genética, Anemia/metabolismo, Proteína Morfogenética Ósea 2/metabolismo, Hepcidinas/metabolismo, Interleucina-6/metabolismo, Hierro/metabolismo, Plásmidos/genética, Regiones Promotoras Genéticas/genética, Factores de Transcripción SOXB1/metabolismo, Sitios de Unión, Técnicas de Silenciamiento del Gen, Vectores Genéticos, Células Hep G2, Luciferasas

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