dos Santos, Jymmys Lopes;
Silva, Ana Mara de Oliveira e;
Souza, Lúcio Marques Vieira;
Pereira, Raquel Oliveira;
Lima, Clésio Andrade;
Abreu, Lucas Silva;
Montalvao, Monalisa Martins;
Correa, Cristiane Bani;
Rabelo, Thallita Kelly;
Duarte, Marcelo Cavalcante;
Aidar, Felipe Jose;
Tavares, Josean Fechine;
Estevam, Charles dos Santos;
Marçal, Anderson Carlos.
In order to understand antidiabetic potential and toxicity, this study aimed to evaluate the acute toxicity and antidiabetic activity of ethanolic extract and ethyl acetate fraction obtained from Coutoubea spicata “nicolau” shoots. Chemical constituents and acute toxicity were investigated. In alloxa...
Extractos Vegetales/química,
Extractos Vegetales/toxicidad,
Extractos Vegetales/farmacología,
Etanol,
Diabetes Mellitus/tratamiento farmacológico,
Gentianaceae/química,
Hiperglucemia/tratamiento farmacológico,
Hipoglucemiantes/química,
Hipoglucemiantes/farmacología,
Cromatografía Líquida de Alta Presión,
Flavonoides/análisis,
Fenoles/análisis,
Supervivencia Celular,
Ratas Wistar,
Peso Corporal/efectos de los fármacos,
Oxidación-Reducción/efectos de los fármacos,
Hipoglucemiantes/toxicidad
SUMMARY: The toxic effects of thioacetamide (TAA) and carbon tetrachloride on the human body are well recognized. In this study, we examined whether TAA intoxication can induce kidney leukocyte infiltration (measured as leukocyte common antigen CD45) associated with the augmentation of the reactive oxyge...
Metformina/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Lesión Renal Aguda/inducido químicamente,
Tioacetamida/toxicidad,
Hipoglucemiantes/uso terapéutico,
Especies Reactivas de Oxígeno,
Antígenos Comunes de Leucocito,
Factor de Necrosis Tumoral alfa,
Inflamación,
Inmunohistoquímica,
Biomarcadores
The present study aimed to document the traditional use of medicinal plants used to treat Diabetes mellitus Type II in Bolivia. Based on the scientific literature were identified 35 medicinal plant species distributed in 21 botanical families, of which 52 % are native to Bolivia and 48 % ar...
Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyper-glycemia that is accompanied, to a greater or lesser extent, by alterations in the metabolism of carbohydrates, proteins and lipids. It is the leading cause of death in develope...
La metformina es el fármaco preferido en el manejo inicial de la diabetes mellitus tipo 2 (DMT2). Aunque se recomienda su uso ampliamente, se debe tener precaución al prescribirla a poblaciones susceptibles a condiciones de riesgo de hipoperfusión sistémica, ya que puede provocar acumulación en el o...
Introducción. El síndrome metabólico (SM) aumenta el ingreso hospitalario y el riesgo de desarrollar COVID-19, los fármacos utilizados para su tratamiento ocasionan efectos secundarios por lo que se ha optado por la búsqueda de alternativas terapéuticas a base de compuestos bioactivos contenidos en...
Ibervillea sonorae (S. Watson) Greene, is a plant native to Mexico, where its roots have been used traditionally for treating Diabetes Mellitus. The aim of this work was to establishment of cell cultures of stem explants of I. sonorae and evaluation of the anti-hyperglycemic activity of ...
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/química,
Hipoglucemiantes/química,
México,
Hipoglucemiantes/administración & dosificación,
Hiperglucemia/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Técnicas de Cultivo de Célula,
Ácidos Grasos/análisis,
Ratas Wistar,
Fenoles/análisis,
Flavonoides/análisis,
Cromatografía Líquida de Alta Presión,
Glucemia/efectos de los fármacos
ABSTRACT Diabetes is a life-threatening disease, and currently available synthetic medicines for treating diabetes are associated with various side effects. Therefore, there is an unmet need to develop herbal remedies against diabetes as an alternative to synthetic medicines. Although local healers use t...
Abstract Present study analysed the therapeutic potential of traditionally acclaimed medicinal herb Nanorrhinum ramosissimum, using plant parts extracted with different solvents (10 mg/mL). Shoot extracts exhibited comparatively better antimicrobial properties, in comparison to root extracts. Total pheno...
Abstract Pterocarpus santalinoides is used in Nigerian ethnomedicine to treat diabetes mellitus. This study aimed to establish the antidiabetic property of the plant, and isolate and characterize its active principle. Dried and pulverized leaves (500 g) of P. santalinoides were extracted with 1.8 L of 80...
Extractos Vegetales/análisis,
Pterocarpus/efectos adversos,
Hipoglucemiantes/análisis,
Diabetes Mellitus/patología,
Acetatos/farmacología,
Cromatografía en Capa Delgada/métodos,
Espectrometría de Masas/métodos,
Espectroscopía de Resonancia Magnética/métodos,
Flavonoides/farmacología,
d0017860,
d0070040
