Results: 1490

Overexpression SPRY2 Suppresses Esophageal Squamous Cell Carcinoma Progression Via Inactivation of ERK/AKT Signaling

Int. j. morphol; 42 (1), 2024
SUMMARY: Esophageal cancer is one of the most aggressive gastrointestinal cancers. Invasion and metastasis are the main causes of poor prognosis of esophageal cancer. SPRY2 has been reported to exert promoting effects in human cancers, which controls signal pathways including PI3K/AKT and MAPKs. However,...

CLCA1 is Poorly Expressed in Stomach Adenocarcinoma and Correlates with Immune Infiltration

Int. j. morphol; 42 (1), 2024
SUMMARY: Calcium-activated chloride channel regulator 1 (CLCA1) is associated with cancer progression. The expression and immunologic function of CLCA1 in stomach adenocarcinoma (STAD) remain unclear. In this investigation, the expression of CLCA1 in STAD tissues and its involvement in the progression an...

Oxytocin neuron activation by acute infusion of Montanoa genus plants in the Wistar rats

In tradition al Mexican medicine, plants from the Montanoa genus, family Asteraceae ( Montanoa tomentosa , Montanoa grandiflora , and Montanoa frutescens ) have been used to induce labor owing to their uterotonic properties like those produced by oxytocin (OXT). However, w hether infusions ...

Polypoid non-neural granular cell tumor of the oral cavity: case report and literature review

Braz. j. oral sci; 23 (), 2024
To report a case of non-neural granular cell tumor (NN-GCT), an uncommon neoplasm, with only six studies worldwide describing cases involving the oral cavity. Methods: A 26-year-old male patient with an erythematous, firm, polypoid nodule in the floor of the mouth that exhibited areas of ulceration and m...

Cáncer de mama en el norte del Perú: subtipos moleculares y HER2 low

RESUMEN El objetivo del estudio fue conocer el perfil inmunohistoquímico del cáncer de mama e identificar el subgrupo HER2 low en la macrorregión norte del Perú. Se realizó un estudio transversal con una muestra de 1176 pacientes atendidos en el Instituto Regional de Enfermedades Neoplásicas Norte ...

Transforming growth factor beta -1 (TGF-β 1) expression in patients with adenomyosis

Abstract Objective: To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis. Methods: A prospective design was performed including 49 patients submitted to hysterectomy. Immunohistochemistry was performed on anatomopathological samples staged in pa...

Nefrectomía radical laparoscópica de tumor renal izquierdo con hallazgos de enfermedad de Rosai-Dorfman: reporte de caso

La enfermedad de Rosai-Dorfman se define como una histiocitosis de curso generalmente benigno, caracterizada por la acumulación ganglionar de histiocitos que presentan emperipolesis y positividad inmunohistoquímica para S-100 y CD68, y negatividad para CD1a y langerina. Su etiología exacta se desconoc...

Segmental histomorphometry of the porcine ureter for use as a vascular xenograft

Acta cir. bras; 39 (), 2024
Purpose: To histologically quantify the different tissues that make up the porcine ureter, (epithelial, connective, and muscular tissue) in the three segments labelled: cranial, middle and caudal, in order to identify the segment most compatible for use as a vascular graft. Methods: Fifteen porcine urete...

Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer

Abstract Objective Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis. This study aimed to evaluate the association b...

The Localization of R-Spondin1 and R-Spondin 3 Peptides in Rat Hypothalamus: An Immunohistochemical Study

Int. j. morphol; 41 (6), 2023
SUMMARY: The R-spondin protein family is a group of proteins that enhance Wnt/b-catenin signaling and have pleiotropic functions in stem cell growth and development. In the literature reviews, there is no histomorphological study showing the localization and distribution of R-spondins in different hypoth...