The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and ...
Trastorno Depresivo/tratamiento farmacológico,
Trastorno Depresivo/metabolismo,
Trastorno Depresivo/psicología,
Modelos Animales de Enfermedad,
Flavonoides/administración & dosificación,
Suspensión Trasera/psicología,
Interleucina-1beta/sangre,
Interleucina-6/sangre,
Ratones Endogámicos C57BL,
Estrés Oxidativo/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/sangre
Acute coronary syndromes are associated with a high prevalence of complications including heart failure (HF). The aim of this study was to investigate the association of novel biomarkers with the occurrence of post-acute myocardial infarction (AMI) HF. A prospective study was conducted with patients admi...
ABSTRACT Objective: To evaluate intervertebral disc levels of inflammatory factor (interleukin 6) and proteinase activity (cathepsin B) in patients with a degenerative disease and serum levels of interleukin 6, serum cathepsin B activity and hyaluronic acid biomarkers. Methods: We conducted immunohisto...
Adyuvantes Inmunológicos/sangre,
Análisis de Varianza,
Biomarcadores/sangre,
Estudios de Casos y Controles,
Catepsina B/sangre,
Ácido Hialurónico/sangre,
Inmunohistoquímica,
Mediadores de Inflamación/sangre,
Interleucina-6/sangre,
Disco Intervertebral/fisiopatología,
Degeneración del Disco Intervertebral/sangre,
Degeneración del Disco Intervertebral/diagnóstico,
Degeneración del Disco Intervertebral/fisiopatología,
Estudios Prospectivos,
Sensibilidad y Especificidad
Milan-Mattos, J C;
Anibal, F F;
Perseguini, N M;
Minatel, V;
Rehder-Santos, P;
Castro, C A;
Vasilceac, F A;
Mattiello, S M;
Faccioli, L H;
Catai, A M.
The term inflammaging is now widely used to designate the inflammatory process of natural aging. During this process, cytokine balance is altered, presumably due to the loss of homeostasis, thus contributing to a greater predisposition to disease and exacerbation of chronic diseases. The aim of the study...
Factores de Edad,
Envejecimiento/fisiología,
Biomarcadores/análisis,
Proteína C-Reactiva/análisis,
Colesterol/sangre,
Inmunosenescencia/fisiología,
Inflamación/sangre,
Interleucina-6/sangre,
Consumo de Oxígeno/fisiología,
Factores Sexuales,
Triglicéridos/sangre,
Factor de Necrosis Tumoral alfa/sangre
Leite, Sandra Augusta de Moura;
Casanovas, Rosana Costa;
Rodrigues, Vandilson Pinheiro;
Pereira, Adriana de Fátima Vasconcelos;
Ferreira, Teresa Cristina Alves;
Nascimento, Flávia Raquel Fernandes do;
Nascimento, Johnny Ramos do;
Gomes-Filho, Isaac Suzart;
Bastos, Marcus Gomes;
Pereira, Antonio Luiz Amaral.
Abstract Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 y...
Biomarcadores/sangre,
Proteína C-Reactiva/análisis,
Estudios de Casos y Controles,
Periodontitis Crónica/sangre,
Periodontitis Crónica/patología,
Periodontitis Crónica/terapia,
Índice de Placa Dental,
Encía/patología,
Hepcidinas/sangre,
Interleucina-6/sangre,
Hierro/sangre,
Persona de Mediana Edad,
Pérdida de la Inserción Periodontal/sangre,
Pérdida de la Inserción Periodontal/patología,
Valores de Referencia,
Aplanamiento de la Raíz/métodos,
Estadísticas no Paramétricas,
Factores de Tiempo,
Resultado del Tratamiento
Santos, João Hugo Abdalla;
Bührer-Sékula, Samira;
Melo, Gisely Cardoso;
Cordeiro-Santos, Marcelo;
Pimentel, João Paulo Diniz;
Gomes-Silva, Adriano;
Costa, Allyson Guimarães;
Saraceni, Valeria;
Da-Cruz, Alda Maria;
Lacerda, Marcus Vinícius Guimarães.
Abstract INTRODUCTION: Immunological control of Mycobacterium tuberculosis infection is dependent on the cellular immune response, mediated predominantly by Th1 type CD4+ T cells. Polarization of the immune response to Th2 can inhibit the host immune protection against pathogens. Patients with tubercul...
Anticuerpos Antihelmínticos/sangre,
Ascariasis/complicaciones,
Ascariasis/inmunología,
Ascaris lumbricoides,
Estudios de Casos y Controles,
Coinfección,
Citocinas/sangre,
Citocinas/inmunología,
Progresión de la Enfermedad,
Citometría de Flujo,
Interleucina-6/sangre,
Interleucina-6/inmunología,
Persona de Mediana Edad,
Factores de Tiempo,
Tuberculosis Pulmonar/complicaciones,
Tuberculosis Pulmonar/inmunología
Cicchitti P, Alejandra;
Quesada, Isabel;
Cejas, Jimena;
Bertona A, Celina;
González V, Joaquín;
Rosales R, Walter;
Esteves M, Guillermo;
Minuchín B, Gabriel;
Rodríguez G, Martín;
Castro, Claudia.
Introduction: Reduction in the expression of inflammatory markers and oxidative stress associated with exercise will protect against cardiovascular complications in Diabetes Mellitus (DM). Aim: The aim of this study was evaluated cardiovascular fitness (VO2 Max), interleukin-6 (IL-6), monocyte chemo-attr...
Capacidad Cardiovascular/fisiología,
Diabetes Mellitus Tipo 1/terapia,
Diabetes Mellitus Tipo 1/fisiopatología,
Ejercicio Físico/fisiología,
Proteínas Quimioatrayentes de Monocitos,
Inflamación,
Estrés Oxidativo,
Biomarcadores,
Sobrepeso/fisiopatología,
Sobrepeso/terapia,
Peroxidación de Lípido,
Consumo de Oxígeno/fisiología,
Interleucina-6/sangre,
Estilo de Vida
SUMMARY OBJECTIVE: We conducted this study to investigate the clinical efficacy of endoscopic retrograde cholangiopancreatography (ERCP) on elder choledocholithiasis and its effects on the levels of TNF-α, IL-1, and IL-6. METHODS: Elder patients with choledocholithiasis were enrolled in this study...
Colangiopancreatografia Retrógrada Endoscópica,
Coledocolitiasis/sangre,
Coledocolitiasis/diagnóstico por imagen,
Coledocolitiasis/cirugía,
Conducto Colédoco/cirugía,
Interleucina-1/sangre,
Interleucina-6/sangre,
Tiempo de Internación,
Persona de Mediana Edad,
Periodo Posoperatorio,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/sangre
Abstract Purpose: To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats. Methods: Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.o. Group 2 received moringa extract (100mg/kg v.o) for 3 weeks. Groups 3 and 4: Stre...
Abstract Purpose: To investigate the effects of baicalin on inflammatory reaction, oxidative stress and protein kinase D1 (PKD1) and nuclear factor-kappa B (NF-κB) protein expressions in severe acute pancreatitis (SAP) rats. Methods: Sixty rats were divided into sham operation, model, and low-, m...
Amilasas/sangre,
Amilasas/efectos de los fármacos,
Antiinflamatorios no Esteroideos/farmacología,
Complejo CD3/sangre,
Complejo CD3/efectos de los fármacos,
Regulación hacia Abajo/efectos de los fármacos,
Flavonoides/farmacología,
Glutatión Peroxidasa/efectos de los fármacos,
Glutatión Peroxidasa/metabolismo,
Interleucina-1/sangre,
Interleucina-6/sangre,
Malondialdehído/metabolismo,
FN-kappa B/efectos de los fármacos,
FN-kappa B/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Pancreatitis/tratamiento farmacológico,
Pancreatitis/metabolismo,
Proteína Quinasa C/efectos de los fármacos,
Proteína Quinasa C/metabolismo,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Superóxido Dismutasa/efectos de los fármacos,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/sangre
