SUMMARY: The aim of this study was to determine the relationship of autophagy-enhancing rapamycin (RAPA) and autophagy- inhibitor 3-methyladenine (3-MA) with Nitric oxide synthases (NOS) in Cisplatin (CIS)-induced neurotoxicity in rats. Rats were divided into 4 groups (n=10): Control was applied saline, ...
Síndromes de Neurotoxicidad,
Sirolimus/farmacología,
Adenina/análogos & derivados,
Adenina/farmacología,
Óxido Nítrico Sintasa/efectos de los fármacos,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Ratas Wistar,
Inmunohistoquímica,
Superóxido Dismutasa,
Catalasa,
Malondialdehído,
Interleucina-6,
Ensayo de Inmunoadsorción Enzimática
SUMMARY: Amiodarone (AMD), an orally powerful antidysrhythmic medication that has caused hepatotoxicity on long-term administration, is commonly used across the world. Silymarin ameliorative effects (SLM); this research elucidated the magnitude of the damage to the liver tissue in AMD. We divided 24 albi...
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Silimarina/administración & dosificación,
Silimarina/farmacología,
Sustancias Protectoras/administración & dosificación,
Sustancias Protectoras/farmacología,
Amiodarona/toxicidad,
Antiarrítmicos/toxicidad,
Hígado/efectos de los fármacos,
Hígado/enzimología,
Hígado/ultraestructura,
Microscopía Electrónica,
Alanina Transaminasa/análisis,
Aspartato Aminotransferasas/análisis,
Estrés Oxidativo,
Superóxido Dismutasa,
Malondialdehído,
Factor de Necrosis Tumoral alfa,
Interleucina-6,
Ratas Endogámicas
Objetivo. Avaliar a relação entre biomarcadores salivares de estresse oxidativo e cárie dentária em crianças. Métodos. Estudos realizados em crianças de até 12 anos comparando biomarcadores salivares de estresse oxidativo como malondialdeído (MDA), superóxido dismutase (SOD), ácido úrico, cap...
ABSTRACT Purpose: Reactive oxygen species (ROS), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) have been shown in the pathogenesis of acrylamide neurotoxicity. Hippophae rhamnoides L. extract (HRE) has a cytoprotective effect by stabilizing the production of ROS, IL-1 ...
ABSTRACT Purpose: The rat cervicitis model was established with 20% phenol glue to explore the therapeutic effect of Kangfuxiaomi shuan II on rat cervicitis and its mechanism. Methods: After modeling, the rats were treated with Shuangzuotai suppository (37.84 mg/kg), Kangfuxiaoyan shuan (205.6 mg/kg) a...
The result of the reaction of free radicals with biomolecules is the formation of substances with the potential of inducing oxidative damage, a condition known as oxidative stress. There are voluminous literature data reporting the association, both as a cause and as a consequence, between different dise...
ABSTRACT Purpose: To evaluate the protective effect of dexmedetomidine on gastric injury induced by ischemia reperfusion (I/R) in rats. Methods: A total of 18 male albino Wistar rats were divided groups as: gastric ischemia reperfusion (GIR), gastric ischemia reperfusion and 50 μg/kg dexmedetomidi...
RESUMEN Objetivos: Evaluar el rol de la L-carnitina (LC) sobre el estrés oxidativo inducido por fructosa en ratas Holtzman. Materiales y métodos: Se realizó un estudio experimental durante 56 días, con cuatro grupos: control, control+LC, fructosa y fructosa+LC. Los grupos con fructosa recibieron e...
SUMMARY: Repeated stress is a risk factor for memory impairment and neurological abnormalities in both humans and animals. We sought to investigate the extent of (i) brain tissue injury; (ii) nitrosative and oxidative stress in brain tissue homogenates; (iii) apoptotic and survival biomarkers in brain ti...
Estrés Psicológico/complicaciones,
Enfermedad Crónica,
Daño Encefálico Crónico/patología,
Apoptosis,
Estrés Nitrosativo,
Estrés Oxidativo,
Modelos Animales de Enfermedad,
Ratas Wistar,
Depresión,
Lesiones Encefálicas/metabolismo,
Óxido Nítrico Sintasa/análisis,
Malondialdehído/análisis,
Superóxido Dismutasa/análisis,
Caspasa 3/análisis,
Proteínas Proto-Oncogénicas c-bcl-2,
Análisis de Varianza,
Conducta Animal,
Biomarcadores,
Corteza Cerebral
ABSTRACT
A few studies have shown that serum brain-derived neurotrophic factor (BDNF) level in post-stroke depression is highly correlated with memory and neuropsychiatric disturbances.
Objective:
This study aimed to elucidate the relationship of serum BDNF, malondialdehyde (MDA), and 8-Hydroxy 2-Deox...
