As proteases fibrinolíticas são capazes de degradar coágulos de fibrina formados dentro dos vasos sanguíneos, evitando a trombose intravascular. Em animais, a tromboflebite, que acomete frequentemente os equinos, ocasiona, em seus casos graves, a obstrução jugular e também um edema de laringe, der...
Abstract Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function. The signs and symptoms observed followin...
Background: Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, biological activity and pathological mechanisms are still scarce. Therefore, the aim o...
Matias, Mariana Santos;
Sousa, Bruna Barbosa de;
Pereira, Déborah Fernanda da Cunha;
Dias, Edigar Henrique Vaz;
Mamede, Carla Cristine Neves;
Queiroz, Mayara Ribeiro de;
Silva, Anielle Christine Almeida;
Dantas, Noelio Oliveira;
Soares, Andreimar Martins;
Costa, Júnia de Oliveira;
Oliveira, Fábio de.
Background: Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disorders. The possible therapeutic potential of toxins with antiplatelet properties may a...
Souza, Markus V. C;
Lino, Anderson D. S;
Ruffoni, Leandro G. D;
Domingos, Mateus M;
Barbosa, Marina R;
Rodrigues, Maria F C;
Ferreira, Fabiano C;
Tomaz, Luciane M;
Canevazzi, Gustavo H. R;
Silva, Natália S;
Teixeira, Jeferson A. A;
Leite, Richard D;
Shiguemoto, Gilberto E;
Perez, Sérgio E. A.
AIMS: The aim of the present study was to investigate the influence of resistance training (RT) and hormone replacement (HR) on MMP-2 activity, biomechanical and physical properties bone of ovariectomized (OVX) rats. METHODS: Sprague-Dawley female rats were grouped into six experimental groups (n = 11 pe...
As neoplasias mieloproliferativas (NMPs) BCR-ABL1 negativas compreendem a mielofibrose primária (PMF), trombocitemia essencial (TE) e a policitemia vera (PV). A patogênese e progressão dessas NMPs não estão completamente elucidadas. As metaloproteinases de matriz (MMPs) degradam a matriz extracelula...
A desnutrição proteica (DP) pode ocasionar alterações na matriz extracelular (MEC) de diferentes órgãos e tecidos, inclusive o hematopoético, com comprometimento funcional. Estudos do nosso laboratório demonstraram, em modelo murino de DP, aumento da expressão proteica de fibronectina (FN) no es...
El objetivo de este estudio fue evaluar el efecto del ejercicio sobre varios biomarcadores. Por primera vez se investigaron los cambios causados por el ejercicio en algunas variables bioquímicas y fisiológicas utilizando un análisis estructural. Los pacientes hipertensos fueron divididos en grupo de e...
Background Snake venoms are complex mixtures of inorganic and organic components, mainly proteins and peptides. Standardization of methods for isolating bioactive molecules from snake venoms is extremely difficult due to the complex and highly variable composition of venoms, which can be influenced by fa...
AIM: The objective of this study was to evaluate the use of MMPs inhibitors (chlorhexidine and EDTA) in bond strength and quality of the hybrid layer of adhesive restorations in normal dentin using two ethanol-based total-etch adhesive systems. MATERIAL AND METHODS: Thirty-two extracted human molars were...
