Results: 27

Metallothionein-2a (rs1610216&rs28366003) gene polymorphisms and the risk of stomach adenocarcinoma

Arq. gastroenterol; 56 (4), 2019
ABSTRACT BACKGROUND: Gastric cancer is the fourth most common cause of worldwide cancer. Also in contrast to the huge advances in curing, the chance of living is very low even in surgery cases. Having a genetic predisposition plays an important role in cancer development. The association between Metall...

Cáncer gástrico hereditario: indicaciones de estudio genético ¿cuando y a quiénes?

Rev. cir. (Impr.); 71 (5), 2019
Resumen El objetivo de esta revisión es realizar una actualización de los conocimientos actuales en cáncer gástrico hereditario, especialmente enfocado a que pacientes tienen indicación de estudio genético y su manejo clínico. En un 5-10% de los cánceres gástricos existe un patrón familiar. Los...

MicroRNA-383-5p inhibits the progression of gastric carcinoma via targeting HDAC9 expression

Braz. j. med. biol. res; 52 (8), 2019
MicroRNAs (miRNAs), as post-transcriptional regulators, have been reported to be involved in the initiation and progression of various types of cancer, including gastric cancer (GC). The present study aimed to investigate the role of miR-383-5p in gastric carcinogenesis. Cell viability was analyzed using...

FGFR1 is an independent prognostic factor and can be regulated by miR-497 in gastric cancer progression

Braz. j. med. biol. res; 52 (1), 2019
Fibroblast growth factor receptor 1 (FGFR1) has been reported in gastric cancer to be a prognostic factor. However, miR-497-targeted FGFR1 has not been explored in the carcinogenesis of gastric cancer. The present study intended to revalidate the prognostic significance of FGFR1 in patients with gastric ...

The ERBB2 gene polymorphisms rs2643194, rs2934971, and rs1058808 are associated with increased risk of gastric cancer

Braz. j. med. biol. res; 52 (5), 2019
Gastric cancer (GC) is the third most lethal type of cancer worldwide. Single nucleotide polymorphisms (SNPs) in regulatory sites or coding regions can modify the expression of genes involved in gastric carcinogenesis, as ERBB2, which encodes for the tyrosine-kinase receptor HER-2. The aim of this work w...

Association of mmp-7 -181A>G polymorphism with colorectal cancer and gastric cancer susceptibility: a systematic review and meta-analysis

ABCD (São Paulo, Impr.); 32 (3), 2019
ABSTRACT Introduction: The matrix metalloproteinase-7 (MMP-7) gene -181A>G polymorphism has been reported to be associated with colorectal cancer (CRC) and gastric cancer (GC) susceptibility, yet the results of these previous results have been inconsistent or controversial. Aim: To elaborate a meta-...

Association of interleukin-10 -592a>c and -819t>c polymorphisms with gastric cancer risk: a systematic review and meta-analysis of 44 case-control studies

ABCD (São Paulo, Impr.); 32 (1), 2019
ABSTRACT Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the poly...

Risk factors associated with the development of gastric cancer — case-control study

Associação de interleucina-10-1082A/polimorfismo G (rs1800896) com suscetibilidade a câncer gástrico: meta-análise de 6. 101 casos e 8. 557 controles

Arq. gastroenterol; 55 (1), 2018
ABSTRACT BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to inve...