Objective: The relationship between biomarkers of amyloid-beta aggregation (Aβ1-42) and/or neurodegeneration (Tau protein) in cerebrospinal fluid (CSF) and cognitive decline is still unclear. We aimed to ascertain whether CSF biomarkers correlate with cognitive performance in healthy and cognitively...
Enfermedad de Alzheimer/líquido cefalorraquídeo,
Enfermedad de Alzheimer/psicología,
Péptidos beta-Amiloides/líquido cefalorraquídeo,
Análisis de Varianza,
Biomarcadores/líquido cefalorraquídeo,
Estudios de Casos y Controles,
Disfunción Cognitiva/líquido cefalorraquídeo,
Estudios de Cohortes,
Pruebas de Estado Mental y Demencia,
Persona de Mediana Edad,
Fragmentos de Péptidos/líquido cefalorraquídeo,
Valores de Referencia,
Estadísticas no Paramétricas,
Proteínas tau/líquido cefalorraquídeo
BACKGROUND: Microalgae are aquatic chlorophyll-containing organisms comprising unicellular microscopic forms, and their biomasses are potential sources of bioactive compounds, biofuels and food-based products. However, the neuroprotective effects of microalgal biomass have not been fully explored. In thi...
Chlorella/química,
Antioxidantes/farmacología,
Inhibidores de la Colinesterasa/farmacología,
Péptidos beta-Amiloides/antagonistas & inhibidores,
Amiloide/efectos de los fármacos,
Extractos Vegetales/farmacología,
Etanol,
Microalgas,
Biomasa,
Cromatografía de Gases y Espectrometría de Masas,
Fármacos Neuroprotectores,
Enfermedad de Alzheimer/prevención & control,
Fenoles/análisis,
Terpenos/análisis,
Extractos Vegetales/química,
Antioxidantes/química,
Espectroscopía Infrarroja por Transformada de Fourier,
Inhibidores de la Colinesterasa/química,
Esteroides/análisis,
Esteroles/análisis,
Ácidos Grasos/análisis
Abstract Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last ...
ABSTRACT Cell physiology is impaired before protein aggregation and this may be more relevant than inclusions themselves for neurodegeneration. The present study aimed to characterize an animal model to enable the analysis of the cell biology before and after protein aggregation. Ten-month-old Lewis rats...
Enfermedad de Alzheimer/metabolismo,
Enfermedad de Alzheimer/patología,
Péptidos beta-Amiloides/efectos de los fármacos,
Péptidos beta-Amiloides/metabolismo,
Western Blotting,
Sistema Nervioso Central/efectos de los fármacos,
Sistema Nervioso Central/metabolismo,
Sistema Nervioso Central/patología,
Modelos Animales de Enfermedad,
Hipocampo/efectos de los fármacos,
Hipocampo/metabolismo,
Hipocampo/patología,
Inmunohistoquímica,
Agregación Patológica de Proteínas/inducido químicamente,
Agregación Patológica de Proteínas/patología,
Rotenona/administración & dosificación,
Sustancia Negra/efectos de los fármacos,
alfa-Sinucleína/efectos de los fármacos,
alfa-Sinucleína/metabolismo,
Ratas Endogámicas Lew,
Reproducibilidad de los Resultados,
Estrés Oxidativo
ABSTRACT CONTEXT AND OBJECTIVE: Dementia is a syndrome characterized by functional and cognitive decline. Alzheimer's disease (AD) is one of the most common causes of dementia and has high prevalence among the elderly. It is known that there is no drug capable of interfering with the course of the dise...
ABSTRACT Objective Increasing evidence demonstrates that oxidative stress and inflammatory are involved in amyloid β (Aβ)-induced memory impairments. Ursolic acid (UA), a triterpenoid compound, has potent anti-inflammatory and antioxidant activities. However, it remains unclear whether UA atte...
A doença de Alzheimer (DA) é a forma de demência degenerativa esporádica mais comum. Caracteristicamente ocorre expressiva perda neuronal progressiva em locais específicos nas pessoas atingidas. O distúrbio degenerativo progressivo se caracteriza pela perda de sinapses, de neurônios cerebrais e po...
A Doença de Alzheimer (DA), caracterizada pela perda da memória e de pelo menos outra função cognitiva, se tornou foco de atenção por parte dos pesquisadores, tendo em vista o aumento de sua prevalência na população mundial. A presença das placas neuríticas, formadas pelo acúmulo do peptídeo...
Abstract: Alzheimers disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, including memory loss, behavioral and psychological symptoms and personality changes. The neuropathological hallmarks of AD are the presence of neuritic (senile) plaques (NP) and neurofibrilla...
