Abstract Objective: To evaluate whether the presence of polymorphisms of peroxisome proliferator-activated receptor gamma PPARγ (Pro 1 2Ala) and PPARGC1B (Ala203Pro) modifies the association between the inorganic arsenic (iAs) methylation capacity and breast cancer (BC). Materials and methods: Mex...
Arsénico/toxicidad,
Arsenicales/metabolismo,
Arsenicales/orina,
Neoplasias de la Mama/epidemiología,
Neoplasias de la Mama/genética,
Proteínas Portadoras/genética,
Estudios de Casos y Controles,
Cromatografía Líquida de Alta Presión,
Exposición a Riesgos Ambientales,
Predisposición Genética a la Enfermedad,
Espectrometría de Masas,
Metilación,
PPAR gamma/genética,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Nucleótido Simple,
Proteínas de Unión al ARN,
Riesgo
In the mammalian lung, respiratory macrophages provide front line defense against invading pathogens and particulate matter. In birds, respiratory macrophages are known as free avian respiratory macrophages (FARM) and a dearth of the cells in the avian lung has been purported to foreordain a weak first l...
BACKGROUND: From ancient times, marine algae have emerged as alternative medicine and foods, contains the rich source of natural products like proteins, vitamins, and secondary metabolites, especially Chlorella vulgaris (C. vulgaris) contains numerous anti-inflammatory, antioxidants and wound healing sub...
Células 3T3-L1/efectos de los fármacos,
Chlorella vulgaris/química,
Extractos Vegetales/farmacología,
Algas Marinas/química,
Células 3T3-L1/fisiología,
Proteínas Quinasas Activadas por AMP/análisis,
Proteínas Quinasas Activadas por AMP/efectos de los fármacos,
Proteínas Quinasas Activadas por AMP/metabolismo,
Adipocitos/citología,
Adipocitos/efectos de los fármacos,
Adipocitos/metabolismo,
Adiponectina/análisis,
Adiponectina/metabolismo,
Diferenciación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Diabetes Mellitus Tipo 2/metabolismo,
Glucosa/metabolismo,
Transportador de Glucosa de Tipo 4/análisis,
Transportador de Glucosa de Tipo 4/efectos de los fármacos,
Transportador de Glucosa de Tipo 4/metabolismo,
PPAR gamma/análisis,
PPAR gamma/efectos de los fármacos,
PPAR gamma/metabolismo,
Células Cultivadas,
Regulación hacia Abajo,
Expresión Génica,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo,
Regulación hacia Arriba
Objective This study aimed to get the genotypic and allelic frequencies of rs1801282 in 179 volunteer donors and 154 patients with Metabolic syndrome (MetS) in Brasilia, Brazil and also examine the association with anthropometric, biochemical and hemodynamic variables in the latter group. MetS comprises ...
Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-lin...
Background The objective of this study was to compare the level differences of mRNA transcription and protein expression of PPARγ, FAS and HSL in different parts of the carcass in different tail-type sheep. Six Tan sheep and six Shaanbei fine-wool sheep aged 9 months were slaughtered and samples wer...
Ovinos,
Ácido Graso Sintasas/genética,
Ácido Graso Sintasas/metabolismo,
PPAR gamma/genética,
PPAR gamma/metabolismo,
Transcripción Genética,
ARN Mensajero,
Esterol Esterasa/genética,
Esterol Esterasa/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Cola (estructura animal)
Background The objective of this study was to investigate proliferator-activated receptor (PPARγ), fatty acid synthase (FAS) and hormone-sensitive lipase (HSL) mRNA and protein expression in fat tails of Tan sheep. Rams from different developmental stages (aged 3, 6, 9, 12, 15 and 18 months) were se...
Ovinos/crecimiento & desarrollo,
Ovinos/genética,
ARN Mensajero,
Proteínas/metabolismo,
Ácido Graso Sintasas/metabolismo,
Ácido Graso Sintasas/genética,
Factores de Transcripción,
PPAR gamma/metabolismo,
PPAR gamma/genética,
Esterol Esterasa/metabolismo,
Esterol Esterasa/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting
Cury, Sarah Santiloni;
Oliveira, Miriane;
Síbio, Maria Teresa;
Clara, Sueli;
Luvizotto, Renata de Azevedo Melo;
Conde, Sandro;
Jorge, Edson Nacib;
Nunes, Vania dos Santos;
Nogueira, Célia Regina;
Mazeto, Gláucia Maria Ferreira da Silva.
A úlcera gástrica é uma doença crônica, de alta prevalência, e a eficácia dos tratamentos farmacológicos disponíveis é limitada pela alta incidência de efeitos adversos. Neste trabalho é mostrado o mecanismo de ação terapêutica e os efeitos toxicológicos da molécula indol-tiazolidínica ...
Tiazolidinadionas (TZDs) são agentes sensibilizadores de insulina que agem por ligação ao receptor gama ativado por proliferador de peroxissomos (PPARγ). Elas têm apresentado efeitos cardioprotetores em humanos e propriedades anti-aterogênicas em modelos animais. Estudos in vitro têm sugerido que ...
