Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats
Braz. j. med. biol. res; 49 (9), 2016
Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib on taurocholate (TAC)-induced acute pancreatitis (AP) in rats, and the role of TGF-β a...
Enfermedad Aguda, Amilasas/sangre, Apoptosis, Western Blotting, Ensayo de Cambio de Movilidad Electroforética, Ensayo de Inmunoadsorción Enzimática, Etiquetado Corte-Fin in Situ, Interleucina-1beta/sangre, Interleucina-6/sangre, Lipasa/sangre, Páncreas/efectos de los fármacos, Páncreas/patología, Pancreatitis/tratamiento farmacológico, Pancreatitis/patología, Peroxidasa/análisis, Inhibidores de Proteínas Quinasas/uso terapéutico, Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores, Pirazoles/uso terapéutico, Quinolinas/uso terapéutico, Resultado del Tratamiento