Results: 28

Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy

Acta cir. bras; 33 (8), 2018
Abstract It is well known that during hepatic operative procedures, it is often critical that the irrigation is interrupted to avoid possible bleeding, blood transfusions, variable intensities, and their short and long-term consequences. It was believed in the past that the flow interruption should not e...

Is the early or delayed remote ischemic preconditioning the more effective from a microcirculatory and histological point of view in a rat model of partial liver ischemia-reperfusion?

Acta cir. bras; 33 (7), 2018
Abstract Purpose: To compare early- and late-effect remote ischemic preconditioning (RIPC) by analysing the microcirculatory, hemodynamic and histological changes in partial liver ischemia-reperfusion of rats. Methods: 60-minute partial liver ischemia followed by 120-minute reperfusion was performed ...

Effects of remote ischemic preconditioning and topical hypothermia in renal ischemia-reperfusion injury in rats

Acta cir. bras; 33 (5), 2018
Abstract Purpose: To evaluate whether combining hypothermia and remote ischemic preconditioning (RIPC) results in protection from ischemia-reperfusion (IR). Methods: Thirty-two Wistar rats underwent right nephrectomy and were randomly assigned to four experimental protocols on the left kidney: warm isc...

Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation

Acta cir. bras; 33 (3), 2018
Abstract Purpose: To investigate the effect of ozone oxidative preconditioning (OzoneOP) on inflammation and oxidative stress injury in rat model of renal transplantation. Methods: Thirty six male Sprague Dawley (SD) rats were randomly divided into three groups. Sham group: rats were treated with open...

Evaluation of the effects of atorvastatin and ischemic postconditioning preventing on the ischemia and reperfusion injury: experimental study in rats

Abstract Introduction: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experiment...

Prophylactic application of laser light restores L-FABP expression in the livers of rats submitted to partial ischemia

Clinics; 73 (), 2018
OBJECTIVES: The objective of the present study was to evaluate the protective effect of pre-conditioning treatment with laser light on hepatic injury in rats submitted to partial ischemia using mitochondrial function and liver fatty acid binding protein as markers. METHODS: Rats were divided into four g...

Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury

Acta cir. bras; 32 (11), 2017
Abstract Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. Methods: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of live...

The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats

Acta cir. bras; 32 (10), 2017
Abstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assi...

Perconditioning combined with postconditioning on kidney ischemia and reperfusion

Acta cir. bras; 32 (8), 2017
Abstract Purpose: To evaluate if combination of perconditioning and postconditioning provides improved renal protection compared to perconditioning alone in a model of renal reperfusion injury. Methods: Thirty rats were assigned into 6 groups: normality; sham; ischemia and reperfusion; postconditionin...

Low-energy shock wave preconditioning reduces renal ischemic reperfusion injury caused by renal artery occlusion

Acta cir. bras; 32 (7), 2017
Abstract Purpose: To evaluate whether low energy shock wave preconditioning could reduce renal ischemic reperfusion injury caused by renal artery occlusion. Methods: The right kidneys of 64 male Sprague Dawley rats were removed to establish an isolated kidney model. The rats were then divided into fou...