Background: Cell culture (spheroid and 2D monolayer cultures) is an essential tool in drug discovery. Piperlongumine (PLN), a naturally occurring alkaloid present in the long pepper (Piper longum), has been implicated in the regulation of GSTP1 activity. In vitro treatment of cancer cells with PLN increa...
Abstract Background: The current evidence suggests that oncological surgery, which is a therapy used in the treatment of solid tumors, increases the risk of metastasis. In this regard, a wide range of tumor cells express Voltage-Gated Sodium Channels (VGSC), whose biological roles are not related to the...
BACKGROUND: Cichoric acid (CA) is extracted from Echinacea purpurea. It is well known and widely used for its immunological function. However, the effect of CA on peripheral blood mononuclear cells (PBMCs) from yaks is still unclear. This study investigated the potential influences of CA on the prolifera...
Echinacea/química,
Ácidos Cafeicos/farmacología,
Succinatos/farmacología,
Proliferación Celular/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Factores de Transcripción,
Leucocitos Mononucleares/citología,
Leucocitos Mononucleares/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática,
Western Blotting,
Reacción en Cadena en Tiempo Real de la Polimerasa,
RNA-Seq,
Citocinas,
Concanavalina A/farmacología
BACKGROUND:
Taraxacum species (commonly known as dandelion) used as herbal medicine have been reported to exhibit an antiproliferative effect on hepatoma cells and antitumor activity in non-small-cell lung cancer cells. Although several investigations have demonstrated the safety of Taraxacum officinale,...
Seguridad,
Pruebas de Mutagenicidad,
Suero,
Urinálisis,
Pruebas de Toxicidad Subaguda,
Ratas Sprague-Dawley,
Cromatografía Líquida de Alta Presión,
Flavonoides/análisis,
Fenol/análisis,
Taraxacum/química,
Medicina de Hierbas,
35514,
Proliferación Celular/efectos de los fármacos,
Técnicas de Cultivo de Tejidos/métodos,
Extractos Vegetales/toxicidad,
Taraxacum/toxicidad
Chloroform extract (CE) and fractions obtained from Aldama arenaria roots were evaluated for their in vitro antiproliferative activity against 10 human tumor cell lines [leukemia (K-562), breast (MCF-7), ovary expressing a multidrug-resistant phenotype (NCI/ADR-RES), melanoma (UACC-62), lung (NCI-H460), ...
Plectranthus/química,
Proliferación Celular/efectos de los fármacos,
Línea Celular Tumoral/efectos de los fármacos,
Técnicas In Vitro,
Etnobotánica,
Extractos Vegetales/farmacología,
Extractos Vegetales/química,
Cuba,
Diterpenos/farmacología,
Diterpenos/química,
Cloroformo
SUMMARY INTRODUCTION Although estrogen therapy is widely used against post-menopausal symptoms, it can present adverse effects, including endometrial cancer. Soy isoflavones are considered a possible alternative to estrogen therapy. However, there are still concerns whether isoflavones exert trophic ef...
Proliferación Celular/efectos de los fármacos,
Cuello del Útero/efectos de los fármacos,
Cuello del Útero/patología,
Epitelio/efectos de los fármacos,
Estrógenos/farmacología,
Inmunohistoquímica,
Isoflavonas/farmacología,
Antígeno Ki-67/análisis,
Membrana Mucosa/efectos de los fármacos,
Ovariectomía,
Fitoestrógenos/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Factor A de Crecimiento Endotelial Vascular/análisis
Breder, J S C;
Pires, A L R;
Azevedo, F F;
Apolinário, P P;
Cantaruti, T;
Jiwani, S I;
Moraes, Â M;
Consonni, S R;
Araújo, E P;
Adams, G G;
Saad, M J A;
Lima, M H M.
The use of specially designed wound dressings could be an important alternative to facilitate the healing process of wounds in the hyperglycemic state. Biocompatible dressings combining chitosan and alginate can speed up wound healing by modulating the inflammatory phase, stimulating fibroblast prolifera...
Alginatos/administración & dosificación,
Vendajes,
Materiales Biocompatibles/administración & dosificación,
Biomarcadores/sangre,
Proliferación Celular/efectos de los fármacos,
Quitosano/administración & dosificación,
Colágeno/efectos de los fármacos,
Diabetes Mellitus Experimental/fisiopatología,
Inflamación/prevención & control,
Ratones Endogámicos C57BL,
Factores de Tiempo,
Cicatrización de Heridas/efectos de los fármacos
Abstract The α-tomatine is a steroidal glycoalkaloid found in immature tomatoes (Lycopersicon esculentum) that has important biological functions including the inhibition of cancer cell growth and preventing metastasis. This study aimed to evaluate the effects of α-tomatine on cytotoxicity, cel...
In this study, we aimed to analyze the anti-cancer effects of β-elemene combined with paclitaxel for ovarian cancer. RT-qPCR, MTT assay, western blot, flow cytometry, and immunohistochemistry were used to analyze in vitro and in vivo anti-cancer effects of combined treatment of β-elemene and pa...
Apoptosis/efectos de los fármacos,
Western Blotting,
Línea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Inmunohistoquímica,
Ratones Endogámicos BALB C,
FN-kappa B/efectos adversos,
FN-kappa B/metabolismo,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/metabolismo,
Neoplasias Ováricas/patología,
Paclitaxel/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Sesquiterpenos/administración & dosificación,
Transducción de Señal,
Transfección
Seregheti, T M Q;
Pinto, A P R;
Gonçalves, M da C;
Antunes, A dos S;
Almeida, W A da S;
Machado, R S;
Silva, J N;
Ferreira, P M P;
Pessoa, C;
Santos, V M R dos;
Nascimento, A M do.
In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4',7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant's aerial parts. The antiproliferative activity of these compounds w...
