P53 regulation and function in normal cells and tumors
Medicina (B.Aires); 60 Suppl 2 (), 2000
Mechanisms to protect organisms from the consequences of DNA damage include the tumor suppressor p53 pathway. p53 protein binds specifically to a DNA consensus sequence to induce growth inhibitory genes or nonspecifically to damaged sites leading to DNA repair or apoptosis. While p53 protein is susceptib...
Apoptosis, Carcinoma de Células Escamosas/metabolismo, Reparación del ADN, Proteínas de Unión al ADN/metabolismo, Regulación Neoplásica de la Expresión Génica, Proteínas de Neoplasias/metabolismo, Proteínas de Neoplasias/fisiología, Proteína p53 Supresora de Tumor/metabolismo, Proteína p53 Supresora de Tumor/fisiología