Abstract: Introduction: Relapse occurs in approximately 20% of Mexican patients with childhood acute lymphoblastic leukemia (ALL). In this group, chemoresistance may be one of the biggest challenges. An overview of complex cellular processes like drug tolerance can be achieved with proteomic studies. ...
Antineoplásicos Fitogénicos/farmacología,
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico,
Proteómica/Métodos,
Vincristina/farmacología,
Adenosina Trifosfato/metabolismo,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Cromatografía Líquida de Alta Presión,
Resistencia a Antineoplásicos,
Regulación Leucémica de la Expresión Génica,
Mitocondrias/metabolismo,
Leucemia-Linfoma Linfoblástico de Células Precursoras/genética,
Proteínas/metabolismo,
Proteoma/metabolismo,
Transducción de Señal/efectos de los fármacos,
Espectrometría de Masa por Ionización de Electrospray
Abstract: Background: Chemical pesticides, widely used in agriculture and vector-borne disease control, have shown toxic effects on the environment and the people in contact with them. Bacillus thuringiensis is a widely used bacterium for alternative and safer control of insect pests. Its toxins are sp...
Bacillus thuringiensis,
Proteínas Bacterianas/farmacología,
Endotoxinas/farmacología,
Proteínas Hemolisinas/farmacología,
Insecticidas/farmacología,
Proteómica/Métodos,
Toxinas de Bacillus thuringiensis,
Proteínas Bacterianas/aislamiento & purificación,
ADN Ribosómico/genética,
Endotoxinas/aislamiento & purificación,
Proteínas Hemolisinas/aislamiento & purificación,
Insecticidas/aislamiento & purificación,
Larva/efectos de los fármacos,
México,
Mariposas Nocturnas/efectos de los fármacos,
Control Biológico de Vectores/Métodos
Torres-Arroyo, Angélica;
Ruiz-Lara, Arturo;
Castillo-Villanueva, Adriana;
Méndez-Cruz, Sara Teresa;
Espinosa-Padilla, Sara Elvia;
Espinosa-Rosales, Francisco Javier;
Zarate-Mondragón, Flora;
Cervantes-Bustamante, Roberto;
Bosch-Canto, Vanessa;
Vizzuett-López, Iris;
Ordaz-Fávila, Juan Carlos;
Oria-Hernández, Jesús;
Reyes-Vivas, Horacio.
Abstract: Proteomics is the study of the expression of changes and post-translational modifications (PTM) of proteins along a metabolic condition either normal or pathological. In the field of health, proteomics allows obtaining valuable data for treatment, diagnosis or pathophysiological mechanisms of d...
Abstract: In recent years, the use of high-throughput omics technologies has led to the rapid discovery of many candidate biomarkers. However, few of them have made the transition to the clinic. In this review, the promise of omics technologies to contribute to the process of biomarker development is des...
Abstract: Acute lymphoblastic leukemia (ALL) affects the quality of life of many children in the world and particularly in Mexico, where a high incidence has been reported. With a proper financial investment and with well-organized institutions caring for those patients, together with solid platforms to ...
Background: Jatropha curcas is a wide-spreading latex-rich biodiesel plant with high oil content in seeds that have always been under intense studies. However, studies are lacking on the latex component that is considered rich in proteins with potentially important physiological functions and secondary m...
Jatropha,
Tallos de la Planta/química,
Látex/química,
Proteínas de Plantas/análisis,
Proteínas de Plantas/aislamiento & purificación,
Proteómica/métodos,
Fenol/química,
Acetona/química,
Cromatografía Liquida,
Espectrometría de Masas en Tándem,
Espectrometría de Masa por Ionización de Electrospray,
Electroforesis en Gel de Poliacrilamida
Abstract Mastitis adversely affects milk production and in general cows do not regain their full production levels post recovery, leading to considerable economic losses. Moreover the percentage decrease in milk production depends on the specific pathogen that caused the infection and enterobacteria are ...
Enterobacteriaceae/clasificación,
Enterobacteriaceae/metabolismo,
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción,
Bovinos,
Girasa de ADN/genética,
Enterobacteriaceae/aislamiento & purificación,
Genes Bacterianos,
Mastitis Bovina/diagnóstico,
Leche/microbiología,
Fenotipo,
Proteómica/métodos,
Análisis de Secuencia de ADN,
Mastitis Bovina/microbiología
Abstract Staphylococcus spp. play an important role in the etiology of bovine mastitis. Staphylococcus aureus is considered the most relevant species due to the production of virulence factors such as slime, which is required for biofilm formation. This study aimed to evaluate biofilm production and its ...
Antibacterianos/farmacología,
Biopelículas,
Mastitis Bovina/microbiología,
Infecciones Estafilocócicas/microbiología,
Staphylococcus aureus/efectos de los fármacos,
Staphylococcus aureus/fisiología,
Resistencia betalactámica,
Proteínas Bacterianas/genética,
Bovinos,
Estudios de Asociación Genética,
Pruebas de Sensibilidad Microbiana,
Proteoma,
Proteómica/métodos,
Staphylococcus aureus/ultraestructura,
Transactivadores/genética,
Factores de Virulencia/genética
Fluoride (F) is a potent anti-cariogenic element, but only an appropriate dose is
effective to have therapeutic action, else systemic toxicity may be observed.
Additionally, two factors, amount of F and time of exposure, drive its action.
Surprisingly, the susceptibility to toxic effects of F is genetica...
Hígado/química,
Hígado/efectos de los fármacos,
Fluoruros/farmacología,
Proteómica/métodos,
Proteínas/análisis,
Fluorosis Dental/metabolismo,
Estrés Oxidativo/fisiología,
Fluorosis Dental/genética,
Factores de Tiempo,
Predisposición Genética a la Enfermedad,
Valores de Referencia
A esporotricose caracteriza-se como uma micose subcutânea causada por fungos dimórficos do gênero Sporothrix, capazes de acometer o homem e uma grande variedade de animais, dentre eles os felinos. A princípio, Sporothrix schenckii era a única espécie conhecida como responsável pela esporotricose. ...
