SUMMARY: Intervertebral disc degeneration (IVDD) is induced by nucleus pulposus (NP) dysfunction as a result of massive loss of NP cells. It has been reported that the acidic microenvironment of the intervertebral disc (IVD) can induce NP cell pyroptosis, and that up-regulation of periostin (POSTN) expre...
Ácidos/química,
Ambiente,
Degeneración del Disco Intervertebral,
Núcleo Pulposo/fisiopatología,
Moléculas de Adhesión Celular/metabolismo,
Núcleo Pulposo/citología,
Proteína con Dominio Pirina 3 de la Familia NLR,
Ratas Sprague-Dawley,
Moléculas de Adhesión Celular/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Ensayo de Inmunoadsorción Enzimática,
Supervivencia Celular,
d0123330
The present study was conducted to ascertain the estrogenic effect of Zhuang Medicated
Thread Moxibustion (ZMTM) and explore its time
-
sensitive impact on estradiol (E2) in female
perimenopausal rats. 40 female rats were randomized into four gr
oups: the control, model, ...
SUMMARY: Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, testosterone inhibition and apoptosis. Accordingly, this study was co...
Camellia sinensis/química,
Extractos Vegetales/farmacología,
Té/química,
Infliximab/farmacología,
Cisplatino/toxicidad,
Testículo/efectos de los fármacos,
Recuento de Espermatozoides,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
Apoptosis,
Estrés Oxidativo,
Inflamación,
Ratas Sprague-Dawley,
Extractos Vegetales/química,
Inmunohistoquímica,
Malondialdehído/análisis,
Glutatión/análisis,
Testículo/patología
SUMMARY: Diabetic cardiomyopathy, characterized by diabetes mellitus (DM) -induced cardiac muscular abnormalities, is a strong inducer of impaired cardiac contraction and arrhythmia. Atrioventricular block, a serious type of arrhythmia resulting from interruption of cardiac impulse conduction via the atr...
SUMMARY: Diabetes mellitus (DM) is a metabolic disorder with rising incidences worldwide. Gastric symptoms of DM have been reported, including nausea, vomiting, bloating, and epigastric pain. Moreover, acute to chronic gastritis and atrophic gastritis occur in DM can affect the chief cells of the gastric...
SUMMARY: To investigate changes of MMP-9 in the rat spleen and hypoxia-induced microvascular basement membrane under high altitude hypoxia. Thirty male specific pathogen-free Sprague Dawley rats were randomly divided into control and hypoxia groups, with 15 rats in each group. The rats in the control gro...
SUMMARY: Breathing is considered a vital function dependent on factors such as adequate permeability of the nasal route, which is linked to physiological functions, intellectual processes, and craniofacial growth. The aim of this study was to determine the changes in the craniomaxillofacial growth and bo...
SUMMARY: Diacylglycerol kinase (DGK) exerts balancing the intracellular level between two-second messengers, diacylglycerol and phosphatidic acid, by its phosphorylation activity. DGK ζ is often localized in cell nuclei, suggesting its involvement in the regulation of intranuclear activities, includ...
Liao, Libin;
Chai, BingRu;
Zhao, Tian;
Liu, Wentao;
Zhang, Xinyi;
Xu, Xiaoxu;
Tian, Xiaohan;
Lv, Mengjiao;
Yao, Xueping;
Bai, Shengbin.
SUMMARY: The objective of this study was to investigate the mechanism of prenatal stress on the cognitive function of offspring, and clarify the change of histone deacetylase 2 (HDAC2) expression in hippocampal neurons of offspring. 16 pregnant SD rats were randomly divided into control group and stress ...
Efectos Tardíos de la Exposición Prenatal,
Estrés Psicológico,
Disfunción Cognitiva,
Histona Desacetilasa 2/metabolismo,
Epigenómica,
Prueba de Laberinto Elevado,
Aprendizaje,
Memoria,
Ratas Sprague-Dawley,
Inmunohistoquímica,
Western Blotting,
Prueba de Campo Abierto,
Neurogénesis,
Hipocampo
SUMMARY: A great deal of attention of air pollution on respiratory health is increasing, particularly in relation to haze days. It is that exposure to cigarette smoke augments the toxicity of common air contaminants, thereby increasing the complexity of respiratory diseases. Although there are various me...
Fumar Cigarrillos/efectos adversos,
Sistema Respiratorio/patología,
Sistema Respiratorio/efectos de los fármacos,
Acuaporinas/metabolismo,
Homeostasis,
Ratas Sprague-Dawley,
Microscopía Electrónica,
Pulmón/patología,
Pulmón/efectos de los fármacos,
Inmunohistoquímica,
Líquidos Corporales/metabolismo
