LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis

Chen, XY; Chen, YH; Zhang, LJ; Wang, Y; Tong, ZC.

Braz. j. med. biol. res; 50 (2), 2017

Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and ...

Algoritmos, Neoplasias Óseas/genética, Perfilación de la Expresión Génica, Regulación Neoplásica de la Expresión Génica/genética, Redes Reguladoras de Genes/genética, Osteosarcoma/genética, Mapas de Interacción de Proteínas/genética

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Disease association and inter-connectivity analysis of human brain specific co-expressed functional modules

Oh, Kimin; Hwang, Taeho; Cha, Kihoon; Yi, Gwan-Su.

Biol. Res; 48 (), 2015

BACKGROUND: In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions. This could also provide a new possibility for the better understanding of differenc...

Encéfalo/metabolismo, Redes Reguladoras de Genes/genética, Vías Nerviosas/metabolismo, Pan troglodytes/genética, Transcriptoma, Perfilación de la Expresión Génica/métodos, Predisposición Genética a la Enfermedad/clasificación, Predisposición Genética a la Enfermedad/genética

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Neutral space analysis for a Boolean network model of the fission yeast cell cycle network

Ruz, Gonzalo A; Timmermann, Tania; Barrera, Javiera; Goles, Eric.

Biol. Res; 47 (), 2014

BACKGROUND: Interactions between genes and their products give rise to complex circuits known as gene regulatory networks (GRN) that enable cells to process information and respond to external stimuli. Several important processes for life, depend of an accurate and context-specific regulation of gene exp...

Ciclo Celular/fisiología, Quinasas Ciclina-Dependientes/metabolismo, Redes Reguladoras de Genes/fisiología, Schizosaccharomyces/fisiología, Modelos Biológicos, Proteínas de Ciclo Celular/metabolismo, Fase G1/fisiología, Schizosaccharomyces/genética, Biología Computacional, Gráficos por Computador, Simulación por Computador, Redes Neurales de la Computación

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