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The significance of variation in the susceptibility of Schistosoma mansoni to the antischistosomal drug oxamniquine

Kinoti, G. K.
Mem. Inst. Oswaldo Cruz; 82 (supl.4), 1987
Clinical and laboratory evidence is reviewed which shows that there is a great deal of variation in the susceptibility of Schistosoma mansoni to oxamniquine. This variation occurs both among endemic regions and within endemic regions in Brazil and Kenya. It is genetically controlled. It is suggested that...
Resistencia a Medicamentos, Nitroquinolinas/farmacología, Oxamniquina, Schistosoma mansoni/genética, Schistosoma mansoni/efectos de los fármacos, Resistencia a Medicamentos, Nitroquinolinas/farmacología, Oxamniquina, Schistosoma mansoni/genética, Schistosoma mansoni/efectos de los fármacos
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Schistosoma mansoni: structural damage after treatment with oxamniquine

Magalhães Filho, Ageu; Melo, Maria Eliane Bezerra de; Padovan, Paulo Antônio; Padovan, Isairas Pereira.
Mem. Inst. Oswaldo Cruz; 82 (supl.4), 1987
The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially...
Nitroquinolinas/farmacología, Oxamniquina/farmacología, Schistosoma mansoni/efectos de los fármacos, Microscopía Electrónica, Schistosoma mansoni/ultraestructura
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