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Results: 26

Therapeutic drug monitoring of benznidazole and nifurtimox: a systematic review and quality assessment of published clinical practice guidelines

Olivera, Mario Javier; Fory, Johana Alexandra; Olivera, Antonio José.
Rev. Soc. Bras. Med. Trop; 50 (6), 2017
Abstract The pharmacological management of adults with chronic-phase Chagas disease is challenging despite it being the recent focus of extensive research. One of the challenges in the current clinical practice guidelines (CPGs) landscape is the existence of non-evidence-based recommendations for the use...
Enfermedad de Chagas/tratamiento farmacológico, Enfermedad Crónica, Monitoreo de Drogas, Nifurtimox/uso terapéutico, Nitroimidazoles/uso terapéutico, Guías de Práctica Clínica como Asunto, Tripanocidas/uso terapéutico
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Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis

Santeliz, Sonia; Caicedo, Peter; Giraldo, Elidiosmar; Alvarez, Carmen; Yustiz, María-Daniela; Rodríguez-Bonfante, Claudina; Bonfante-Rodríguez, Romina; Bonfante-Cabarcas, Rafael.
Mem. Inst. Oswaldo Cruz; 112 (9), 2017
BACKGROUND As chronic Chagas disease does not have a definitive treatment, the development of alternative therapeutic protocols is a priority. Dipyridamole (DPY) is an alternative to counteract the pathophysiological phenomena involved in Chagas cardiomyopathy. OBJECTIVE To evaluate the therapeutic ef...
Enfermedad Aguda, Cardiomiopatía Chagásica/tratamiento farmacológico, Dipiridamol/uso terapéutico, Modelos Animales de Enfermedad, Tripanocidas/uso terapéutico, Nifurtimox/uso terapéutico
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Chagas disease: review of needs, neglect, and obstacles to treatment access in Latin America

Pinheiro, Eloan; Brum-Soares, Lucia; Reis, Renata; Cubides, Juan-Carlos.
Rev. Soc. Bras. Med. Trop; 50 (3), 2017
Abstract After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health problems in Latin America; the overall cost of CD treatment is approximately 7 billion United States dollars per...
Brasil, Enfermedad de Chagas/tratamiento farmacológico, Enfermedad de Chagas/economía, Costos de los Medicamentos/estadística & datos numéricos, Accesibilidad a los Servicios de Salud, Necesidades y Demandas de Servicios de Salud, América Latina, Nitroimidazoles/economía, Nitroimidazoles/uso terapéutico, Tripanocidas/economía, Tripanocidas/uso terapéutico
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Pharmacotherapeutic follow-up of patients with Chagas disease using benznidazole: drug-related problems and pharmaceutical interventions

Correia, João Paulo Ramalho; Costa, Alanna Carla da; Rocha, Eduardo Arrais; Quidute, Ana Rosa Pinto; Cândido, Darlan da Silva; Ponciano, Ângela Maria de Souza; Fonteles, Marta Maria de França; Oliveira, Maria de Fátima.
Rev. Soc. Bras. Med. Trop; 50 (3), 2017
Abstract INTRODUCTION Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory stu...
Brasil, Enfermedad de Chagas/tratamiento farmacológico, Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/clasificación, Estudios de Seguimiento, Cumplimiento de la Medicación/estadística & datos numéricos, Persona de Mediana Edad, Nitroimidazoles/efectos adversos, Nitroimidazoles/uso terapéutico, Factores Socioeconómicos, Tripanocidas/efectos adversos, Tripanocidas/uso terapéutico
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Adverse systemic reaction to benznidazole

Coronel, María Verónica Pacheco; Frutos, Laura Oriente; Muñoz, Eva Calabuig; Valle, Diana Kury; Rojas, Dolores Hernández Fernández de.
Rev. Soc. Bras. Med. Trop; 50 (1), 2017
Abstract Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benznidaz...
Enfermedad de Chagas/tratamiento farmacológico, Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos, Persona de Mediana Edad, Nitroimidazoles/efectos adversos, Nitroimidazoles/uso terapéutico, Tripanocidas/efectos adversos, Tripanocidas/uso terapéutico
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Actividad tripanocida de Piper solmsianum C. DC. sobre formas epimastigota y tripomastigota de Trypanosoma cruzi
Trypanocidal activity of Piper solmsianum C. DC. against epimastigote and trypomastigote forms of Trypanosoma cruzi

Mejía-Parra, Jorge I Jhoao; Pérez-Araujo, Michel A; Roldán-Rodríguez, Judith; Rojas-Idrogo, Consuelo; Kato, Massuo J; Delgado-Paredes, Guillermo E.
Rev. cuba. med. trop; 68 (3), 2016
Introducción: la infección por Trypanosoma cruzi, conocida como enfermedad de Chagas, es un problema importante de salud pública en países de América Central y Sudamérica.Objetivo: evaluar la actividad de extractos crudos de acetato de etilo de plantas in vitro de 6-8 meses y 10-12 meses de edad, d...
Enfermedad de Chagas/patología, Tripanocidas/uso terapéutico, Trypanosoma cruzi/patogenicidad, América Central, América del Sur
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High seroconversion rates in Trypanosoma cruzi chronic infection treated with benznidazole in people under 16 years in Guatemala

Brum-Soares, Lucia; Cubides, Juan-Carlos; Burgos, Iris; Monroy, Carlota; Castillo, Leticia; González, Selene; Viñas, Pedro Albajar; Urrutia, Pedro Pablo Palma.
Rev. Soc. Bras. Med. Trop; 49 (6), 2016
Abstract INTRODUCTION: Geographical, epidemiological, and environmental differences associated with therapeutic response to Chagas etiological treatment have been previously discussed. This study describes high seroconversion rates 72 months after benznidazole treatment in patients under 16 years from a...
Anticuerpos Antiprotozoarios/sangre, Enfermedad de Chagas/tratamiento farmacológico, Enfermedad de Chagas/inmunología, Enfermedad Crónica, Ensayo de Inmunoadsorción Enzimática, Guatemala, Nitroimidazoles/uso terapéutico, Seroconversión, Resultado del Tratamiento, Tripanocidas/uso terapéutico, Trypanosoma cruzi/inmunología
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Chronic Heart Disease after Treatment of Oral Acute Chagas Disease

Antunes, Andrei Fornanciari; Maduro, Simão Gonçalves; Pereira, Bruna Valessa Moutinho; Barbosa, Maria das Graças Vale; Guerra, Jorge Augusto de Oliveira; Ferreira, João Marcos Bemfica Barbosa.
Arq. bras. cardiol; 107 (2), 2016
Abstract We describe the recurrence of cardiac abnormalities in a patient treated during the acute phase of Chagas disease after outpatient follow-up of 5 years....
Enfermedad Aguda, Arritmias Cardíacas/tratamiento farmacológico, Arritmias Cardíacas/etiología, Cardiomiopatía Chagásica/tratamiento farmacológico, Enfermedad de Chagas/tratamiento farmacológico, Electrocardiografía, Nitroimidazoles/uso terapéutico, Recurrencia, Tripanocidas/uso terapéutico
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