Abstract INTRODUCTION: Patients with Chagas disease (CD), caused by Trypanosoma cruzi, present a higher risk of developing other chronic diseases, which may contribute to CD severity. Since CD is underreported in the southern state of Paraná, Brazil, we aimed to characterize clinical and epidemiologic...
El objetivo de este estudio fue evaluar la percepción de equipos de salud de atención en primer nivel y público objetivo acerca de facilitadores y barreras para el abordaje de Chagas a partir de una intervención multifacética, en una zona endémica. Se realizaron 12 entrevistas semiestructuradas y g...
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD1...
BACKGROUND Chagas disease, resulting from Trypanosoma cruzi infections, continues to be a health concern mainly in Latin American countries where the parasite is endemic. The laboratory diagnosis of a chronic infection is determined through serological assays for antibodies against T. cruzi and several ...
BACKGROUND Calpains are present in almost all organisms and comprise a family of calcium-dependent cysteine peptidases implicated in crucial cellular functions. Trypanosoma cruzi, the causative agent of Chagas disease, presents an expansion on this gene family with unexplored biological properties. OBJ...
Cascabulho, Cynthia M;
Meuser-Batista, Marcelo;
Moura, Kelly Cristina G de;
Pinto, Maria do Carmo;
Duque, Thabata Lopes Alberto;
Demarque, Kelly C;
Guimarães, Ana Carolina Ramos;
Manso, Pedro Paulo de Abreu;
Pelajo-Machado, Marcelo;
Oliveira, Gabriel M;
Castro, Solange L De;
Menna-Barreto, Rubem FS.
BACKGROUND Chagas disease, which is caused by the protozoan Trypanosoma cruzi, is endemic to Latin America and mainly affects low-income populations. Chemotherapy is based on two nitrocompounds, but their reduced efficacy encourages the continuous search for alternative drugs. Our group has characterise...
Enfermedad Aguda,
Antiinflamatorios,
Enfermedad de Chagas/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Electrocardiografía,
Naftoquinonas/química,
Naftoquinonas/uso terapéutico,
Nitroimidazoles/química,
Nitroimidazoles/uso terapéutico,
Parasitemia/tratamiento farmacológico,
Factores de Tiempo,
Tripanocidas/química,
Tripanocidas/uso terapéutico
Santos, Valéria Regina Cavalcante dos;
Antunes, Dina;
Souza, Dilma do Socorro Moraes de;
Moreira, Otacilio Cruz;
Lima, Igor Campos de Almeida;
Farias-de-Oliveira, Désio A;
Lobo, João Pedro;
de Meis, Ernesto;
Coura, José Rodrigues;
Savino, Wilson;
Junqueira, Angela Cristina Verissimo;
de Meis, Juliana.
Oral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to oral Trypanosoma cruzi transmission. Clinical and epidemiol...
Enfermedad Aguda,
Alanina Transaminasa/sangre,
Aspartato Aminotransferasas/sangre,
Biomarcadores/sangre,
Brasil/epidemiología,
Estudios de Casos y Controles,
Enfermedad de Chagas/sangre,
Enfermedad de Chagas/enzimología,
Enfermedad de Chagas/fisiopatología,
Enfermedad de Chagas/transmisión,
Factor VIIa/análisis,
Hígado/enzimología,
Hígado/fisiopatología,
Persona de Mediana Edad,
Carga de Parásitos,
Estudios Prospectivos,
Proteína C/análisis
BACKGROUND Deforestation, driven by anthropogenic change in land use, influences the behaviour and abundance of vector-borne diseases. For various species of Chagas disease vectors, there is evidence that change in land use affects population density and abundance. Triatoma dimidiata is the most importa...
Abstract INTRODUCTION: Triatomine bugs are vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. METHODS: Triatomine bugs were collected and identified following established protocols. In addition, infection with T. cruzi was detected by microscopic and molecular analysis. RESULTS: We...
Abstract INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil's Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type,...
Brasil/epidemiología,
Enfermedad de Chagas/tratamiento farmacológico,
Estudios Transversales,
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiología,
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos,
Pruebas de Hemaglutinación,
Hospitales Públicos,
Incidencia,
Persona de Mediana Edad,
Nitroimidazoles/efectos adversos,
Nitroimidazoles/uso terapéutico,
Índice de Severidad de la Enfermedad,
Factores Socioeconómicos,
Tripanocidas/efectos adversos,
Tripanocidas/uso terapéutico
