INTRODUCCIÓN: El trasplante renal es el tratamiento de elección para pacientes con insuficiencia renal crónica. Los inmunosupresores como los inhibidores de la calcineurina pueden estar asociados a efectos adversos. El Síndrome Doloroso por Inhibidores de la Calcineurina (SDIC) se caracteriza por do...
Abstract: One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring...
La tormenta tiroidea es una condición infrecuente y potencialmente fatal. En la literatura han sido descritas varias presentaciones inusuales de la misma; sin embargo, la disfunción multiorgánica es rara vez vista. Aquí describimos un caso en una mujer de 36 años de edad con enfermedad de Graves sub...
Abstract: Background: Many factors are currently being identified as potential inductors of skin cancer in patients after a liver transplant, among them, immunosuppressive regimen. Objective: To study the factors that influence the incidence of skin cancer in patients after liver transplant. Methods: ...
Carcinoma Basocelular/epidemiología,
Carcinoma de Células Escamosas/epidemiología,
Terapia de Inmunosupresión/efectos adversos,
Trasplante de Hígado/efectos adversos,
Neoplasias Cutáneas/epidemiología,
Factores de Edad,
Brasil/epidemiología,
Carcinoma Basocelular/etiología,
Carcinoma Basocelular/patología,
Carcinoma de Células Escamosas/etiología,
Carcinoma de Células Escamosas/patología,
Diabetes Mellitus/epidemiología,
Inmunosupresores/uso terapéutico,
Incidencia,
Modelos Logísticos,
Estudios Retrospectivos,
Factores de Riesgo,
Neoplasias Cutáneas/etiología,
Neoplasias Cutáneas/patología
ABSTRACT Purpose: Administration of eye drops containing antihistamines or sodium cromoglycate and its derivatives for the treatment of allergic keratoconjunctivitis is often insufficient and usually requires the addition of corticosteroids. However, the risk of complications, such as glaucoma and catar...
Administración Tópica,
Conjuntivitis Alérgica/tratamiento farmacológico,
Ciclosporina/administración & dosificación,
Estudios de Seguimiento,
Inmunosupresores/administración & dosificación,
Queratoconjuntivitis/tratamiento farmacológico,
Microscopía/métodos,
Estudios Prospectivos,
Índice de Severidad de la Enfermedad,
Tacrolimus/administración & dosificación,
Resultado del Tratamiento
ABSTRACT BACKGROUND There is evidence that shows that calcineurin inhibitors may be useful for the treatment of severe ulcerative colitis. However, evidence regarding the efficacy of tacrolimus for remission induction in this setting is scarce. OBJECTIVE To develop a systematic review on the existing...
Carvalho, Vânia O;
Solé, Dirceu;
Antunes, Adriana A;
Bau, Ana E. Kiszewski;
Kuschnir, Fábio C;
Mallozi, Márcia C;
Markus, Jandrei R;
Silva, Maria G. Nascimento e;
Pires, Mário C;
Mello, Marice E. El Achkar;
Rosário Filho, Nelson A;
Sarinho, Emanuel S. Cavalcanti;
Chong-Neto, Herberto J;
Silva, Luciana R;
Rubini, Norma P. M.
Nas últimas décadas o conhecimento sobre a etiopatogenia da dermatite atópica (DA) avançou muito. Além da identificação dos principais agentes desencadeantes e/ou agravantes envolvidos na expressão clínica da DA, verificou-se ser a integridade da barreira cutânea um dos pontos fundamentais para...
Dermatitis Atópica,
Inmunoterapia,
Alergia e Inmunología,
Terapéutica,
Inmunosupresores,
Piel,
Agentes Mojantes,
Ciclosporina,
Corticoesteroides,
Inhibidores de la Calcineurina,
Guías como Asunto,
Sociedades Médicas
ABSTRACT Purpose: To assess the efficacy of monotherapy using tacrolimus eye drops versus sodium cromoglycate for the treatment of vernal keratoconjunctivitis (VKC). Methods: Randomized double-masked controlled trial comparing the efficacy of tacrolimus 0.03% eye drops t.i.d. (Group 1) with sodium crom...
Conjuntivitis Alérgica/tratamiento farmacológico,
Conjuntivitis Alérgica/patología,
Cromolin Sódico/uso terapéutico,
Método Doble Ciego,
Inmunosupresores/uso terapéutico,
Soluciones Oftálmicas/uso terapéutico,
Índice de Severidad de la Enfermedad,
Estadísticas no Paramétricas,
Tacrolimus/uso terapéutico,
Factores de Tiempo,
Resultado del Tratamiento,
Agudeza Visual
Abstract Introduction: Immunosuppression of T lymphocytes is required for preventing acute rejection after transplantation and for the treatment of chronic autoimmune and inflammatory diseases. The laboratory monitoring for this therapy is the measurement of T cells by immunophenotyping, aiming the targ...
Abstract Calcineurin inhibitors (CNIs) are used widely for maintenance immunosuppression in renal transplant recipients. However, their side effect profile has led researchers to attempt to find safer alternatives that can maintain effective long-term immunosuppression with less toxicity. Belatacept is a...
