Abstract INTRODUCTION Visceral leishmaniasis (VL) is a neglected disease, with territorial expansion and regional differences in Brazil that require explanation. This study aimed to describe changes in the epidemiology of VL in Brazil from 2001 to 2014. METHODS The incidence rates, sociodemographic a...
Abstract INTRODUCTION: This study aimed to draw clinical and epidemiological comparisons between visceral leishmaniasis (VL) and VL associated with human immunodeficiency virus (HIV) infection. METHOD: Retrospective study. RESULTS: Of 473 cases of VL, 5.5% were coinfected with HIV. The highest prop...
Distribución por Edad,
Factores de Edad,
Brasil/epidemiología,
Coinfección/tratamiento farmacológico,
Coinfección/epidemiología,
Coinfección/fisiopatología,
Infecciones por VIH/tratamiento farmacológico,
Infecciones por VIH/epidemiología,
Infecciones por VIH/fisiopatología,
Incidencia,
Leishmaniasis Visceral/tratamiento farmacológico,
Leishmaniasis Visceral/epidemiología,
Leishmaniasis Visceral/fisiopatología,
Persona de Mediana Edad,
Recurrencia,
Estudios Retrospectivos,
Distribución por Sexo,
Factores Socioeconómicos,
Resultado del Tratamiento
Abstract In Brazil, Leishmania infantum mainly affects humans and dogs. The state of Bahia presents many dogs that are positive for this parasite. Despite the importance of epidemiology in this region, there are still very few studies that have assessed the genetic characteristics of L. infantum. The aim...
La leishmaniasis es una enfermedad causada por parásitos obligados intracelulares pertenecientes al género Leishmania y que reconoce tres formas clínicas principales: cutánea, visceral y mucocutánea. Es una patología del grupo de las "enfermedades desatendidas". Es la única enfermedad tropical tra...
Abstract INTRODUCTION The control of reservoirs for Leishmania infantum -induced zoonotic visceral leishmaniasis requires the identification of dogs posing a population risk. Here, we assessed the performance of several assays to identify Lutzomyia longipalpis infectious dogs. METHODS We evaluated 99...
Anticuerpos Antiprotozoarios/sangre,
Enfermedades de los Perros/diagnóstico,
Enfermedades de los Perros/parasitología,
Enfermedades de los Perros/transmisión,
Leishmania infantum,
Leishmaniasis Visceral/diagnóstico,
Leishmaniasis Visceral/parasitología,
Leishmaniasis Visceral/transmisión,
Leishmaniasis Visceral/veterinaria,
Mosquitos Vectores/parasitología,
Psychodidae/parasitología,
Sensibilidad y Especificidad,
Pruebas Serológicas/métodos,
Pruebas Serológicas/veterinaria
Abstract INTRODUCTION: The drugs available for visceral leishmaniasis (VL) treatment in Brazil have specific characteristics in terms of operability, effectiveness, toxicity, and cost. The aim of this study was to estimate the direct costs of therapies recommended by the Ministry of Health (MH) for VL t...
Anfotericina B/economía,
Anfotericina B/uso terapéutico,
Antiprotozoarios/economía,
Antiprotozoarios/uso terapéutico,
Brasil,
Protocolos Clínicos,
Ácido Desoxicólico/economía,
Ácido Desoxicólico/uso terapéutico,
Combinación de Medicamentos,
Costos de la Atención en Salud/estadística & datos numéricos,
Leishmaniasis Visceral/tratamiento farmacológico,
Leishmaniasis Visceral/economía,
Meglumina/economía,
Meglumina/uso terapéutico,
Antimoniato de Meglumina,
Compuestos Organometálicos/economía,
Compuestos Organometálicos/uso terapéutico
BACKGROUND Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules du...
Quimiocina CXCL10/uso terapéutico,
Citocinas/inmunología,
Interferón gamma/análisis,
Interleucina-10/biosíntesis,
Interleucina-4/biosíntesis,
Leishmania infantum,
Leishmaniasis Visceral/tratamiento farmacológico,
Leishmaniasis Visceral/inmunología,
Leishmaniasis Visceral/parasitología,
Hígado/patología,
Macrófagos/efectos de los fármacos,
Ratones Endogámicos BALB C,
Tamaño de los Órganos/fisiología
O efeito de um protocolo quimioterápico multidrogas contra a leishmaniose visceral (LV) canina, sobre a capacidade de transmissão de Leishmania infantum ao vetor, foi analisado por meio de xenodiagnóstico. Trinta e cinco cães naturalmente infectados foram avaliados antes e durante o tratamento com a ...
Abstract This study was about a semi-quantitative analysis of T lymphocytes (CD4+ and CD8+, FoxP3+ regulatory T cells), and macrophages in the gut wall of dogs naturally infected with Leishmania infantum. Thirteen dogs were divided into three groups: group 1 (G1, n=5), dogs with canine visceral leishmani...
Abstract INTRODUCTION: Molecular techniques have been shown to be alternative methods for the accurate detection of infectious and parasitic diseases, such as the leishmaniases. The present study describes the optimization and evaluation of a duplex real-time quantitative PCR (qPCR) protocol developed f...
