Results: 354

Real-time PCR assay for the diagnosis of pleural tuberculosis

Colomb. med; 48 (2), 2017
Abstract Introduction: The diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak. Objective: To establish the operating characteristics of real-time polymerase chain re...

Nasal swab real-time PCR is not suitable for in vivo diagnosis of bovine tuberculosis

Pesqui. vet. bras; 37 (6), 2017
Bovine tuberculosis (bTB) is a zoonosis causing economic losses and public health risks in many countries. The disease diagnosis in live animals is performed by intradermal tuberculin test, which is based on delayed hypersensitivity reactions. As tuberculosis has complex immune response, this test has li...

Incidencia de mycobacterium tuberculosis en muestras extrapulmonares procesadas por el ensayo MODS – TB en el Instituto SELADIS de junio del 2015 a diciembre del 2016

Con-ciencia (La Paz); 5 (1), 2017
La tuberculosis extrapulmonar es una manifestación de la tuberculosis que se da cuando la bacteria Mycobacterium tuberculosis pasa del parénquima pulmonar a otros órganos por vía hematógena, linfática o por contigüidad. Entre diversos métodos de detección del bacilo de Koch en sitios diferentes ...

Tuberculosis among prison staff in Rio Grande do Sul

Rev. bras. enferm; 70 (2), 2017
ABSTRACT Objective: to evaluate the risk of infection and illness caused by Mycobacterium tuberculosis among health care and security staff in prisons in two regions of Rio Grande do Sul (RS). Method: cross-sectional study involving prison staff. An interview and sputum smear microscopy and culture wer...

Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis

Mem. Inst. Oswaldo Cruz; 112 (3), 2017
BACKGROUND Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The better understanding of important metabolic pathways from M. tuberculosis can contribute to the development of novel therapeutic and prophylactic strategies to combat TB. Nucleoside hydrol...

Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RDRio genotype

Mem. Inst. Oswaldo Cruz; 112 (3), 2017
BACKGROUND Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RDRio. The strain has been associated with different characteristics of the disease...

Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs

An. acad. bras. ciênc; 89 (1), 2017
ABSTRACT In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activit...

Interleucina-2 no tratamento adjuvante de paciente com linfocitopenia CD4 idiopática e tuberculose disseminada

Linfocitopenia CD4 idiopática (LCI) é uma imunodeficiência rara e grave caracterizada por uma diminuição inexplicável da contagem absoluta de linfócitos T CD4, a qual está associada a infecções oportunistas. Existem poucos relatos de casos na literatura que descrevem a IL2 como uma opção tera...

Performance of a molecular assay to detect Mycobacterium tuberculosis complex DNA in clinical specimens: multicenter study in Brazil

Mem. Inst. Oswaldo Cruz; 112 (2), 2017
BACKGROUND In high tuberculosis (TB) burden countries, there are few data on the performance of new molecular commercialised assays developed locally. OBJECTIVE To evaluate the performance of a new molecular commercialised assay for TB diagnosis (Detect-TB) in three laboratories. METHODS A total of ...

Bacterial immunostat: mycobacterium tuberculosis lipids and their role in the host immune response

Abstract: The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an inf...