INTRODUCCIÓN: Antecedentes: El presente dictamen expone la evaluación de tecnología de la eficacia y seguridad de golimumab en pacientes con artritis psoriásica refractaria a FARMES, etanercep e infliximab. Aspectos Generales: La Artritis Inflamatoria es una enfermeda autoinmune inflamatoria crónica...
ABSTRACT Purpose: We evaluated the efficacy of lycopene, a dietary carotenoid and potent antioxidant, against ocular inflammation and oxidative stress in an experimental uveitis model. Methods: Endotoxin-induced uveitis (EIU) was induced in Sprague-Dawley rats by a single subcutaneous injection of 200 ...
Antiinflamatorios/uso terapéutico,
Antioxidantes/uso terapéutico,
Humor Acuoso/metabolismo,
Carotenoides/uso terapéutico,
Modelos Animales de Enfermedad,
Ojo/patología,
Interleucina-6/metabolismo,
Lipopolisacáridos,
Licopeno,
Óxido Nítrico/metabolismo,
Estrés Oxidativo,
Ratas Sprague-Dawley,
Factor de Necrosis Tumoral alfa/metabolismo,
Uveítis/inducido químicamente,
Uveítis/tratamiento farmacológico,
Uveítis/patología
ABSTRACT Objective: To evaluate the prevalence of systemic and localized infection by Candida species and its possible association with demographic, clinical and laboratory manifestations and therapy in patients with rheumatic diseases taking TNF blockers. Methods: Consecutive patients with rheumatic d...
Anticuerpos Monoclonales/efectos adversos,
Anticuerpos Monoclonales/uso terapéutico,
Antirreumáticos/efectos adversos,
Antirreumáticos/uso terapéutico,
Candida/aislamiento & purificación,
Candidiasis/epidemiología,
Candidiasis/inmunología,
Huésped Inmunocomprometido,
Persona de Mediana Edad,
Prevalencia,
Enfermedades Reumáticas/tratamiento farmacológico,
Enfermedades Reumáticas/inmunología,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Abstract During the last decade, different studies have converged to evidence the high prevalence of comorbidities in subjects with psoriasis. Although a causal relation has not been fully elucidated, genetic relation, inflammatory pathways and/or common environmental factors appear to be underlying the ...
Anticuerpos Monoclonales/uso terapéutico,
Psoriasis/tratamiento farmacológico,
Enfermedades Cardiovasculares/tratamiento farmacológico,
Comorbilidad,
Diabetes Mellitus/tratamiento farmacológico,
Dislipidemias/tratamiento farmacológico,
Hipertensión/tratamiento farmacológico,
Síndrome Metabólico/tratamiento farmacológico,
Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico,
Obesidad Abdominal/tratamiento farmacológico,
Factores de Riesgo,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Introduction: Portal hypertension (PH) is characterized by vasodilatation in the portal system and the bowel is one of the severely affected organs. N-acetylcysteine (NAC) is a molecule with important properties and widely used in clinical practice. Objective: To evaluate NAC action in the bowel of anim...
Hipertensión Portal,
Inflamación,
Enfermedades Inflamatorias del Intestino,
Vena Porta,
Western Blotting,
FN-kappa B,
Factor de Necrosis Tumoral alfa,
Estrés Oxidativo,
Modelos Animales,
Acetilcisteína,
Peroxidación de Lípido,
Superóxido Dismutasa,
Óxido Nítrico,
Mucosa Intestinal,
Antioxidantes,
Gastritis,
Hepatitis
Summary We report the case of a patient with rheumatoid arthritis who, after 2 months of treatment with etanercept, showed disseminated asymptomatic violaceous papules. Biopsy of the skin lesion showed chronic granulomatous dermatitis with negative staining for fungi and acid-fast bacilli (AFB). After di...
Abstract The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during the use of...
ABSTRACT Objective: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. Material and Methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg...
Vasos Sanguíneos/patología,
Mejilla/patología,
Antagonistas del Ácido Fólico/efectos adversos,
Expresión Génica,
Hippophae/química,
Interleucina-1beta/análisis,
Interleucina-1beta/efectos de los fármacos,
Labio/patología,
Malondialdehído/análisis,
Metotrexato/efectos adversos,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Reproducibilidad de los Resultados,
Estomatitis/inducido químicamente,
Estomatitis/tratamiento farmacológico,
Estomatitis/patología,
Lengua/patología,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/análisis,
Factor de Necrosis Tumoral alfa/efectos de los fármacos
Objective: Perinatal depressive symptoms often co-occur with other inflammatory morbidities of pregnancy. The goals of our study were 1) to examine whether changes in inflammatory markers from the third trimester of pregnancy to 12 weeks postpartum were associated with changes in depressive symptoms; 2) ...
Factores de Edad,
Biomarcadores/sangre,
Índice de Masa Corporal,
Proteína C-Reactiva/análisis,
Depresión Posparto/sangre,
Ensayo de Inmunoadsorción Enzimática,
Edad Gestacional,
Interleucina-10/sangre,
Interleucina-6/sangre,
Modelos Lineales,
Estudios Longitudinales,
Persona de Mediana Edad,
Periodo Posparto/sangre,
Periodo Posparto/psicología,
Tercer Trimestre del Embarazo/sangre,
Tercer Trimestre del Embarazo/psicología,
Escalas de Valoración Psiquiátrica,
Valores de Referencia,
Encuestas y Cuestionarios,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/sangre
ABSTRACT Objective: To evaluate 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography–computed tomography (PET–CT) and serum levels of different cytokines and matrix metalloproteinases (MMPs) in patients with Takayasu arteritis (TA) and associations with disease activity. ...
