Results: 5035

Perfil de utilización de antibióticos en hospitales de tercer y cuarto nivel de atención de tres departamentos de Paraguay, 2017

Introducción: Los antibióticos constituyen uno de los grupos farmacológicos de mayor prescripción y uso, ocupando el primer o segundo lugar en los gastos de farmacia de un hospital. Se estima que el 70% el uso de los antibióticos es inadecuado. Objetivo: Determinar el perfil de utilización de antib...

Evaluación del efecto de Aloe barbadensis sobre el peso en ratones normopesos y obesos

La obesidad es el trastorno metabólico más frecuente, para el tratamiento es fundamental el cambio del tipo alimentación y mantener un estilo de vida saludable. La publicidad engañosa sobre productos denominados milagrosos conlleva a un consumo desmedido, no controlado y sin previa evaluación de los...

Resistencia plasmídica a colistin por el gen mcr-1 en Enterobacteriaceae en Paraguay

La resistencia a las polimixinas mediada por plásmidos (gen mcr-1) representa una amenaza para la salud pública, puesto que colistina es utilizada en la práctica médica como una de las últimas alternativas para el tratamiento de gérmenes multiresistentes. Este estudio describe la circulaciónde cep...

Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections

Braz. j. infect. dis; 22 (1), 2018
ABSTRACT Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AI...

In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil

Braz. j. infect. dis; 22 (1), 2018
ABSTRACT The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Suscept...

Retrospective evaluation of the clinical characteristics associated with Corynebacterium species bacteremia

Braz. j. infect. dis; 22 (1), 2018
ABSTRACT Objectives: Corynebacterium spp. are becoming recognized as pathogens that potentially cause various infections. We aimed to evaluate the clinical characteristics associated with Corynebacterium spp. bacteremia. Patients and methods: We retrospectively reviewed the medical records of all adult...

Ophthalmic adverse effects of nasal decongestants on an experimental rat model

Arq. bras. oftalmol; 81 (1), 2018
ABSTRACT Purpose: To investigate the potential effects of chronic exposure to a nasal decongestant and its excipients on ocular tissues using an experimental rat model. Methods: Sixty adult male Wistar rats were randomized into six groups. The first two groups were control (serum physiologic) and Otriv...

Dietas altas en grasas y sus efectos sobre el intestino

El objetivo de esta revisión fue exponer el conocimiento actual sobre la relación existente entre dietas altas en grasa (DAG), alteraciones morfológicas de la mucosa intestinal, efectos inflamatorios y cáncer intestinal. Las DAG inicialmente producen aumento de la microbiota patógena, lo que reduce ...

Effect of titanium tetrafluoride varnish on fibroblasts (NIH/3T3): viability assay, morphological analysis and cell signals for apoptotic pathways

Current knowledge supports the application of TiF4 varnish to protect against tooth caries and erosion; however, it is indispensable to know its cytotoxic potential and the mechanism involved on it before applying in patients. Therefore, this study aimed to evaluate 1) The cytotoxic effect of titanium te...

Avaliação do efeito antiproliferativo da apocinina e diapocinina em células de osteossarcoma humano

O osteossarcoma (OS) é o tumor maligno primário mais comum do tecido ósseo, caracterizado pela formação de osteócitos anormais. Apesar do avanço nas terapias convencionais (quimioterapia e retirada do tumor), essas não conseguem eliminar totalmente as células tumorais e impedir a progressão da ...