Breast cancer is the most common cause of cancer among women in most countries (WHO). Ovarian hormone disorder is thought to be associated with breast tumorigenesis. The present study investigated the effects of estrogen and progesterone administration on cell proliferation and underlying mechanisms in b...
Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel wer...
Marasmius androsaceus is a medicinal fungus mainly used to treat various forms of pain in China. This study investigated the analgesic effects of an ethanol extract of M. androsaceus (MAE) and its potential molecular mechanisms. Oral administration of MAE (50, 200, and 1000 mg/kg) had significant analges...
Hormones regulate hepatic gene expressions to maintain metabolic homeostasis. Ectonucleotide pyrophosphatase/phosphodiesterase 1 has been thought to interfere with insulin signaling. To determine its potential role in the regulation of metabolism, we analyzed its gene (Enpp1) expression in the liver of r...
Dexametasona/farmacología,
Inducción Enzimática/efectos de los fármacos,
Ayuno/metabolismo,
Regulación Enzimológica de la Expresión Génica/efectos de los fármacos,
Glucocorticoides/farmacología,
Células Hep G2,
Hipoglucemiantes/farmacología,
Insulina/farmacología,
Resistencia a la Insulina,
Hígado/enzimología,
Hidrolasas Diéster Fosfóricas/biosíntesis,
Hidrolasas Diéster Fosfóricas/efectos de los fármacos,
Hidrolasas Diéster Fosfóricas/genética,
Pirofosfatasas/biosíntesis,
Pirofosfatasas/efectos de los fármacos,
Pirofosfatasas/genética,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa
Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wo...
Apoptosis/efectos de los fármacos,
Western Blotting,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/patología,
Línea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Medicamentos Herbarios Chinos,
Citometría de Flujo,
Glucósidos/farmacología,
Neoplasias Hepáticas Experimentales/tratamiento farmacológico,
Neoplasias Hepáticas Experimentales/patología,
Ratones Endogámicos BALB C,
Ratones Desnudos,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Estilbenos/farmacología
Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to its anti-inflammatory, antioxidant, and neuroprotective effects, cannabidiol (CBD) has been used as a therapeutic ...
Antiinflamatorios/uso terapéutico,
Cannabidiol/uso terapéutico,
Modelos Animales de Enfermedad,
Enteritis/prevención & control,
Enfermedades Fetales/metabolismo,
Enfermedades Fetales/patología,
Gastrosquisis/metabolismo,
Gastrosquisis/patología,
Inmunohistoquímica,
Intestinos/efectos de los fármacos,
Nitratos/metabolismo,
Óxido Nítrico Sintasa de Tipo II/análisis,
Nitritos/metabolismo,
Ratas Sprague-Dawley
This study aimed to investigate the protective effect of salvinorin A on the cerebral pial artery after forebrain ischemia and explore related mechanisms. Thirty Sprague-Dawley rats received forebrain ischemia for 10 min. The dilation responses of the cerebral pial artery to hypercapnia and hypotension w...
Isquemia Encefálica/tratamiento farmacológico,
Isquemia Encefálica/metabolismo,
Arterias Cerebrales/efectos de los fármacos,
Arterias Cerebrales/fisiopatología,
Cromonas/administración & dosificación,
GMP Cíclico/líquido cefalorraquídeo,
GMP Cíclico/metabolismo,
Modelos Animales de Enfermedad,
Diterpenos de Tipo Clerodano/antagonistas & inhibidores,
Diterpenos de Tipo Clerodano/farmacología,
Morfolinas/administración & dosificación,
NG-Nitroarginina Metil Éster,
Naltrexona/administración & dosificación,
Naltrexona/análogos & derivados,
Fosfatidilinositol 3-Quinasas/metabolismo,
Ratas Sprague-Dawley,
Transducción de Señal
Because of weight gain, women often discontinue hormonal contraception, especially depot medroxyprogesterone acetate (DMPA). Our objective was to conduct a systematic review of studies describing dietary intake or eating behavior in DMPA users to understand whether the use of DMPA is associated with chan...
The prevalence of cardiovascular and metabolic diseases is increased in postmenopausal women, which contributes to the burden of illnesses in this period of life. Yerba mate (Ilex paraguariensis) is a native bush from Southern South America. Its leaves are rich in phenolic components, which may have anti...
Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. N...
Escarabajos/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/patología,
Cuerpo Adiposo/química,
Cromatografía de Gases y Espectrometría de Masas,
Regulación de la Expresión Génica,
Transportador de Glucosa de Tipo 4/efectos de los fármacos,
Transportador de Glucosa de Tipo 4/metabolismo,
Hipoglucemiantes/aislamiento & purificación,
Hipoglucemiantes/uso terapéutico,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Hígado/patología,
PPAR gamma/efectos de los fármacos,
PPAR gamma/metabolismo,
Páncreas/efectos de los fármacos,
Páncreas/metabolismo,
Páncreas/patología,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Extractos de Tejidos/aislamiento & purificación,
Extractos de Tejidos/uso terapéutico
