Results: 5035

Hacer bien una fecha: entre el cuidado y la maximización del placer en consumidores de drogas sintéticas

Physis (Rio J.); 28 (3), 2018
Resumen En este artículo analizamos los procesos de vulnerabilidad y las prácticas de cuidado individuales y grupales en relación a los consumos de drogas de jóvenes que asisten a fiestas electrónicas en la Ciudad Autónoma de Buenos Aires, Argentina. Los resultados provienen de una investigación c...

Improved antimelanogenesis and antioxidant effects of polysaccharide from Cuscuta chinensis Lam seeds after enzymatic hydrolysis

Braz. j. med. biol. res; 51 (7), 2018
Cuscuta chinensis polysaccharide (CPS) was extracted using hot water and enzymatically hydrolyzed C. chinensis polysaccharide (ECPS) was produced by the mannase enzymatic hydrolysis process. The purpose of this research was to investigate the antimelanogenic activity of ECPS and CPS in B16F10 melanoma ce...

Effect of bisacodyl on rats with slow transit constipation

Braz. j. med. biol. res; 51 (7), 2018
The effect of bisacodyl on the treatment of rats with slow transit constipation (STC) was studied. Forty-five female Wister rats were divided into control group, STC group, and STC bisacodyl group. The immunohistochemical method was used to determine interstitial cells of Cajal (ICC) and the expression o...

Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review

Braz. j. med. biol. res; 51 (8), 2018
Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been frequently investigated ...

Anethole reduces oxidative stress and improves in vitro survival and activation of primordial follicles

Braz. j. med. biol. res; 51 (8), 2018
Primordial follicles, the main source of oocytes in the ovary, are essential for the maintenance of fertility throughout the reproductive lifespan. To the best of our knowledge, there are no reports describing the effect of anethole on this important ovarian follicle population. The aim of the study was ...

Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes

Braz. j. med. biol. res; 51 (8), 2018
Excessive exposure to ultraviolet (UV) rays can cause damage of the skin and may induce cancer, immunosuppression, photoaging, and inflammation. The long non-coding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) is involved in multiple human biological processes. However, its role in UVB-induced kera...

Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease

Braz. j. med. biol. res; 51 (8), 2018
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resis...

Determination of multidrug resistance mechanisms in Clostridium perfringens type A isolates using RNA sequencing and 2D-electrophoresis

Braz. j. med. biol. res; 51 (8), 2018
In this study, we screened differentially expressed genes in a multidrug-resistant isolate strain of Clostridium perfringens by RNA sequencing. We also separated and identified differentially expressed proteins (DEPs) in the isolate strain by two-dimensional electrophoresis (2-DE) and mass spectrometry (...

Interleukin-6 contributes to myocardial damage in pregnant rats with reduced uterine perfusion pressure

Braz. j. med. biol. res; 51 (8), 2018
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusi...

Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis

Braz. j. med. biol. res; 51 (9), 2018
We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses were...