Guarana (Paullinia cupana) is habitually ingested by people in the Amazon region and is a key ingredient in various energy drinks consumed worldwide. Extension in longevity and low prevalence of chronic age-related diseases have been associated to habitual intake of guarana. Anti-aging potential of guara...
DNA repair pathways, cell cycle checkpoints, and redox protection systems are essential factors for securing genomic stability. The aim of the present study was to analyze the effect of Ilex paraguariensis (Ip) infusion and one of its polyphenolic components rutin on cellular and molecular damage induced...
Antimutagênicos/farmacología,
Supervivencia Celular/efectos de los fármacos,
Supervivencia Celular/efectos de la radiación,
Células Cultivadas,
Cromatografía Liquida,
Roturas del ADN de Doble Cadena,
Reparación del ADN,
ADN de Hongos/efectos de la radiación,
Relación Dosis-Respuesta en la Radiación,
Rayos gamma,
Ilex paraguariensis/química,
Espectrometría de Masas,
Mutagénesis,
Tasa de Mutación,
Extractos Vegetales/farmacología,
Protección Radiológica/métodos,
Reproducibilidad de los Resultados,
Rutina/farmacología,
Saccharomyces cerevisiae/efectos de los fármacos,
Saccharomyces cerevisiae/efectos de la radiación
Abstract Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocam...
ABSTRACT The aim of the present study was to investigate the effect of donor pH on the transdermal permeability of the model drugs across rat skin and also to determine the major route of transport of the drugs. Weakly acidic drugs (partition coefficient) ibuprofen (3.6), aceclofenac (3.9), glipizide (1....
Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying mechanism were studied. The trypan blue staining ass...
Antineoplásicos Fitogénicos/farmacología,
Apoptosis/efectos de los fármacos,
Western Blotting,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Neoplasias del Colon/metabolismo,
Neoplasias del Colon/patología,
Flavonoides/farmacología,
Células HCT116,
ARN Interferente Pequeño,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Proteína p53 Supresora de Tumor/efectos de los fármacos,
Proteína p53 Supresora de Tumor/metabolismo
We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, vasoactive intestinal peptide (VIP), and corticotro...
Atropina/farmacología,
Corticosterona/sangre,
Hormona Liberadora de Corticotropina/antagonistas & inhibidores,
Hormona Liberadora de Corticotropina/metabolismo,
Hormona Liberadora de Corticotropina/farmacología,
Inhibidores Enzimáticos/farmacología,
Vaciamiento Gástrico/efectos de los fármacos,
Vaciamiento Gástrico/fisiología,
Guanosina Monofosfato/metabolismo,
Óxido Nítrico/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Factores de Tiempo,
Valores de Referencia
Lactate modulates the expression of lactate oxidation complex (LOC)-related genes and cardiac blood flow under physiological conditions, but its modulatory role remains to be elucidated regarding pathological cardiac stress. The present study evaluated the effect of lactate on LOC-related genes expressio...
Catalasa/análisis,
Expresión Génica,
Ventrículos Cardíacos/efectos de los fármacos,
Ventrículos Cardíacos/metabolismo,
Ácido Láctico/análisis,
Ácido Láctico/metabolismo,
Ácido Láctico/farmacología,
Complejos Multienzimáticos/análisis,
Infarto del Miocardio/genética,
Infarto del Miocardio/metabolismo,
NADH NADPH Oxidorreductasas/análisis,
Perfusión,
Ratas Wistar,
Factores de Tiempo
Coelho-de-Souza, A N;
dos-Santos, C F;
Lopes-Filho, L N;
Holanda, F R;
Oliveira, A C;
Gomes-Vasconcelos, Y A;
Oliveira, K A;
Ferreira-da-Silva, F W;
Silva-Alves, K S;
Leal-Cardoso, J H.
Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently phar...
Analgésicos/farmacología,
Antiinflamatorios/farmacología,
Fabaceae/química,
Nocicepción/efectos de los fármacos,
Aceites Volátiles/farmacología,
Dimensión del Dolor,
Extractos Vegetales/farmacología,
Aceites de Plantas/farmacología,
Distribución Aleatoria,
Reproducibilidad de los Resultados,
Semillas/química,
Factores de Tiempo,
Resultado del Tratamiento
Abstract Free gingival grafting, the most predictable technique to increase the keratinized gingiva, leaves an open wound on the palate and the resulting discomfort during the healing phase is a significant concern. This study was intended to evaluate the effect of topical erythropoietin on healing of th...
Administración Bucal,
Eritropoyetina/administración & dosificación,
Colgajos Tisulares Libres,
Encía/trasplante,
Persona de Mediana Edad,
Hueso Paladar/efectos de los fármacos,
Hueso Paladar/cirugía,
Repitelización/efectos de los fármacos,
Repitelización/fisiología,
Reproducibilidad de los Resultados,
Estadísticas no Paramétricas,
Factores de Tiempo,
Resultado del Tratamiento
Abstract The objective of the present study was to evaluate the effect of different surface treatments and polymerization protocols on the bond strength of brackets to enamel, and the degree of conversion of the bonding agents. 120 bovine crowns were embedded in acrylic resin blocks and sanded. Next, the...
Grabado Ácido Dental/métodos,
Adhesividad/efectos de los fármacos,
Análisis de Varianza,
Luces de Curación Dental,
Esmalte Dental/química,
Esmalte Dental/efectos de los fármacos,
Curación por Luz de Adhesivos Dentales/métodos,
Ensayo de Materiales,
Soportes Ortodóncicos,
Transición de Fase,
Ácidos Fosfóricos/química,
Polimerizacion/efectos de los fármacos,
Distribución Aleatoria,
Valores de Referencia,
Reproducibilidad de los Resultados,
Cementos de Resina/química,
Auto-Curación de Resinas Dentales/métodos,
Resistencia al Corte,
Factores de Tiempo
