Muñoz-Villagrán, C;
Contreras, F;
Cornejo, F;
Figueroa, M;
Valenzuela-Bezanilla, D;
Luraschi, R;
Reinoso, C;
Rivas-Pardo, J;
Vásquez, C;
Castro, M;
Arenas, F.
BACKGROUND: There Is an emerging field to put Into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, although their cellular effect(s) or target(s) in a particular organism are still unk...
SUMMARY OBJECTIVE Nuclear factor erythroid-2 related factor 2 (Nrf2)/ antioxidant response element (ARE) is a novel defensive pathway involved in the oxidative and chemical stress of cells. The aim of the study was to explore the role of Nrf2 on the apoptosis of human disc nucleus pulpous cells induced...
Drought can be viewd as a perturbation in running waters and fish are often trapped in isolated pools, where deterioration of water quality may be stressful. We investigated how this extreme condition influences response of oxidative stress biomarkers. The response of the characid Astyanax elachylepis wa...
França, E E T;
Gomes, J P V;
De Lira, J M B;
Amaral, T C N;
Vilaça, A F;
Júnior, M D S Paiva;
Júnior, U F Elihimas;
Júnior, M A V Correia;
Júnior, L A Forgiarini;
Costa, M J C;
Andrade, M A;
Ribeiro, L C;
De Castro, C M M B.
Early mobilization is beneficial for critically ill patients because it reduces muscle weakness acquired in intensive care units. The objective of this study was to assess the effect of functional electrical stimulation (FES) and passive cycle ergometry (PCE) on the nitrous stress and inflammatory cytome...
Biomarcadores/sangre,
Enfermedad Crítica/rehabilitación,
Enfermedad Crítica/terapia,
Citocinas/sangre,
Estimulación Eléctrica/métodos,
Inflamación/inmunología,
Inflamación/metabolismo,
Unidades de Cuidados Intensivos,
Terapia Pasiva Continua de Movimiento/métodos,
Estrés Nitrosativo/fisiología,
Estrés Oxidativo/fisiología,
Músculo Cuádriceps/fisiopatología,
Respiración Artificial/métodos
Abstract Objective: This study evaluated the effects of local vitamin C treatment on tissue advanced glycation end products (AGE), interleukin (IL)-6, 8-hydroxy-2-deoxyguanosine (8-OHdG), and matrix metalloproteinases (MMP)-8 in tissues; serum C-terminal telopeptide fragments (CTX); and alveolar bone lo...
Pérdida de Hueso Alveolar,
Ácido Ascórbico/administración & dosificación,
Colágeno Tipo I,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Productos Finales de Glicación Avanzada,
Interleucina-6,
Metaloproteinasa 8 de la Matriz,
Estrés Oxidativo,
Péptidos,
Periodontitis/tratamiento farmacológico,
Ratas Sprague-Dawley
Atherosclerosis (AS) is a common vascular disease, which can cause apoptosis of vascular endothelial cells. Notoginsenoside R1 (NGR1) is considered an anti-AS drug. MicroRNAs (miRNAs) are believed to play a vital role in cell apoptosis and angiogenesis. This study aimed to explore the mechanism of NGR1 f...
Apoptosis/efectos de los fármacos,
Western Blotting,
Ensayo de Inmunoadsorción Enzimática,
Ginsenósidos/farmacología,
Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos,
Células Endoteliales de la Vena Umbilical Humana/metabolismo,
Inmunoprecipitación,
Inflamación/metabolismo,
Lipoproteínas LDL/metabolismo,
MicroARNs/efectos adversos,
MicroARNs/metabolismo,
FN-kappa B/antagonistas & inhibidores,
Estrés Oxidativo/efectos de los fármacos,
Especies Reactivas de Oxígeno,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal,
Receptor Toll-Like 4/antagonistas & inhibidores,
Activación Transcripcional,
Regulación hacia Arriba
Dong, Degang;
Deng, Zhongping;
Yan, Zhangren;
Mao, Wenli;
Yi, Jun;
Song, Mei;
Li, Qiang;
Chen, Jun;
Chen, Qi;
Liu, Liang;
Wang, Xi;
Huang, Xiuqin;
Wang, Wanchun.
Snakebites remain a major life-threatening event worldwide. It is still difficult to make a positive identification of snake species by clinicians in both Western medicine and Chinese medicine. The main reason for this is a shortage of diagnostic biomarkers and lack of knowledge about pathways of venom-i...
Abstract Gallic acid (GA), as a strong antioxidant, was selected in this study to investigate its possible nephroprotective effects against gentamicin (GM)-induced nephrotoxicity. Twenty-four rats were separated into three groups (n=8): group 1 (control group) received saline (0.5 mL/day), group 2 (GM gr...
Ácido Gálico/química,
Gentamicinas/efectos adversos,
Ácido Gálico/uso terapéutico,
Antioxidantes/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Enfermedades Renales/inducido químicamente,
Enfermedades Renales/tratamiento farmacológico,
Enfermedades Renales/patología,
Ratas Wistar,
Biomarcadores,
Modelos Animales de Enfermedad,
Lipoproteínas HDL,
Colesterol,
Lipoproteínas LDL,
Antibacterianos/efectos adversos
BACKGROUND Oxidative stress is responsible for generating DNA lesions and the 8-oxoguanine (8-oxoG) is the most commonly lesion found in DNA damage. When this base is incorporated during DNA replication, it could generate double-strand DNA breaks and cellular death. MutT enzyme hydrolyzes the 8-oxoG fro...
Antimonio/toxicidad,
Antiprotozoarios/farmacología,
Proteínas de Escherichia coli/genética,
Proteínas de Escherichia coli/metabolismo,
Escherichia coli,
Guanina/análogos & derivados,
Guanina/farmacología,
Peróxido de Hidrógeno/toxicidad,
Leishmania braziliensis/efectos de los fármacos,
Leishmania braziliensis/enzimología,
Leishmania infantum/efectos de los fármacos,
Leishmania infantum/enzimología,
Estrés Oxidativo/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Pirofosfatasas/genética,
Pirofosfatasas/metabolismo,
Conejos,
Superóxido Dismutasa/genética,
Superóxido Dismutasa/metabolismo
BACKGROUND: Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS remain ambiguous. In this study, we further investigated whether electroacupuncture (EA...
