The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qR...
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Apoptosis,
Artesunato/farmacología,
Artesunato/uso terapéutico,
Linfocitos T CD4-Positivos/citología,
Linfocitos T CD4-Positivos/efectos de los fármacos,
Diferenciación Celular,
Regulación hacia Abajo,
Citometría de Flujo,
Ratones Endogámicos C57BL,
MicroARNs/metabolismo,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/inmunología,
Células TH1/citología,
Células TH1/efectos de los fármacos
Benvenutti, Régis Carlos;
Gomes, Denise B;
Zanchet, Barbara;
Locateli, Gelvani;
Vechia, Cristian Alex Dalla;
Zanotelli Serpa, Patrícia;
Lutinski, Junir;
Rodrigues Junior, Sinval Adalberto;
Schönell, Amanda Patrícia;
Diel, Kriptsan Abdon Poletto;
Miorando, Daniela;
Ernetti, Jackeline;
Alves, Bianca de Oliveira;
Zilli, Gabriela Adriany Lisboa;
Banzato, Thais Petrochelli;
Ruiz, Ana Lúcia Tasca Gois;
Vidal Gutiérrez, Max;
Vilegas, Wagner;
Roman Junior, Walter Antônio.
Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. Th...
Abstract Objective: To verify differences between salivary flow in pediatric cancer patients before starting antineoplastic treatment and in healthy pediatric patients. Material and Methods: This is an observational, cross-sectional, paired study with sample of 120 children and adolescents (3-18 years)...
Introdução: A síndrome mão-pé é uma reação adversa experimentada por vários pacientes em tratamento para o câncer e fator preditor de morbidade e mortalidade. Objetivo: Avaliar as evidências científicas relacionadas à identificação, prevenção e tratamento da síndrome mão-pé induzida p...
Introdução: A segurança do paciente vem adquirindo grande importância em níveis nacional e Internacional, especialmente na oncologia, na qual há uma preocupação crescente com os erros/eventos adversos relacionados às drogas quimioterápicas antineoplásicas, tendo como principal premissa a quali...
Se presentó un paciente masculino de 69 años con una colestasis
extrahepática, pérdida de peso, astenia y anorexia, antecedentes de
pancreatitis crónica, diabetes mellitus e hipertensión arterial, el cual fue diagnosticado con adenocarcinoma de páncreas con metástasis
esplénica. Se le realizó c...
Viscarra, Tamara;
Buchegger, Kurt;
Jofre, Ignacio;
Riquelme, Ismael;
Zanella, Louise;
Abanto, Michel;
Parker, Alyssa C;
Piccolo, Stephen R;
Roa, Juan Carlos;
Ili, Carmen;
Brebi, Priscilla.
BACKGROUND: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding...
Antineoplásicos/farmacología,
Carboplatino/farmacología,
Resistencia a Antineoplásicos/genética,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Neoplasias Ováricas/genética,
Transcriptoma/efectos de los fármacos,
Muerte Celular/efectos de los fármacos,
Muerte Celular/genética,
Neoplasias Ováricas/tratamiento farmacológico,
Neoplasias Ováricas/patología,
Transcriptoma/genética,
Línea Celular Tumoral,
Fenotipo,
Análisis de Secuencia de ARN,
Transducción de Señal
BACKGROUND: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSCLC). Methods: PELI3 expression in NSCLC tissue samples was determined by the immunohistochemistry. The transcripts abundance of PELI3 was measured with real-time PCR. The protein...
Carcinoma de Pulmón de Células no Pequeñas/metabolismo,
Regulación hacia Abajo/fisiología,
Neoplasias Pulmonares/metabolismo,
MicroARNs/metabolismo,
Ubiquitina-Proteína Ligasas/metabolismo,
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/patología,
MicroARNs/uso terapéutico,
Ubiquitina-Proteína Ligasas/farmacología,
Línea Celular Tumoral,
Colorantes,
Modelos Animales de Enfermedad,
Sales de Tetrazolio,
Tiazoles
BACKGROUND: Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently required to improve AML clinical outcomes. 4-Amino-2-trifluoromethyl-phenyl retinate (...
Antineoplásicos/farmacología,
Especies Reactivas de Oxígeno/metabolismo,
Retinoides/farmacología,
Diferenciación Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Fosfohidrolasa PTEN/efectos de los fármacos,
Fosfohidrolasa PTEN/metabolismo,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Línea Celular Tumoral,
Regulación hacia Abajo,
Fluoroinmunoensayo,
Leucemia Mieloide Aguda,
Transducción de Señal
ABSTRACT Introduction: Gastric gastrointestinal tumors (GIST) are a rare and usually asymptomatic neoplasm that can present as abdominal mass in more advanced scenarios. Since surgical resection is the main aspect of the treatment, locally advanced tumors require multivisceral resection and, therefore, ...
