BACKGROUND: Hyperoxia at resuscitation increases oxidative stress, and even brief exposure to high oxygen concentrations during stabilization may trigger organ injury with adverse long-term outcomes in premature infants. We studied the long-term effects of short-term perinatal oxygen exposure on cell cyc...
OBJECTIVES: Human immunodeficiency virus-positive (HIV+) individuals can experience a decrease in antioxidants. Such deficiency can make inner ear cells and synapses more vulnerable to oxidative stress, resulting in auditory alterations, even in the presence of normal thresholds. This study aims to compa...
We investigated changes in oxidative biomarkers in brain regions such as brainstem, cerebellum, and cerebral cortex of 3-, 6-, 18-, 24-, and 30-month-old rats. We also assessed the effects of low-intensity exercise on these biomarkers in these regions of 6-, 18-, and 24-month-old rats that started exerci...
Envejecimiento/metabolismo,
Envejecimiento/fisiología,
Biomarcadores/análisis,
Encéfalo/metabolismo,
Fémur/química,
Fémur/diagnóstico por imagen,
Peroxidación de Lípido,
Peróxidos Lipídicos/análisis,
Oxidación-Reducción,
Estrés Oxidativo/fisiología,
Condicionamiento Físico Animal/fisiología,
Ratas Wistar
Rheumatoid arthritis (RA) is an autoimmune disease of knee joints involving pain and inflammation. Rhoifolin is a plant flavonoid known to have antioxidant and anti-inflammatory properties. This study was taken to identify the effect of rhoifolin on complete Freund's adjuvant (CFA)-induced arthritis in t...
Artritis Experimental/tratamiento farmacológico,
Artritis Experimental/metabolismo,
Artritis Reumatoide/tratamiento farmacológico,
Artritis Reumatoide/metabolismo,
Biomarcadores/sangre,
Citocinas/sangre,
Disacáridos/administración & dosificación,
Flavonoides/administración & dosificación,
Adyuvante de Freund/administración & dosificación,
Glicósidos/administración & dosificación,
Interleucina-1beta/sangre,
Interleucina-6/sangre,
FN-kappa B/efectos de los fármacos,
FN-kappa B/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/sangre
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear...
Aydın, Emre;
Yıldırım, Yaşar;
Aydin, Fatma Yilmaz;
Bahadir, Mehmet Veysi;
Kaplan, Ibrahim;
Kadiroğlu, Berfin;
Ketani, Muzaffer Aydin;
Yilmaz, Zülfükar;
Kadiroğlu, Ali Kemal;
Yilmaz, Mehmet Emin.
Abstract INTRODUCTION: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in t...
Antiinflamatorios no Esteroideos/administración & dosificación,
Antiinflamatorios no Esteroideos/farmacología,
Modelos Animales de Enfermedad,
Etanercept/administración & dosificación,
Etanercept/farmacología,
Inflamación/patología,
Inflamación/prevención & control,
Inyecciones Intraperitoneales,
Riñón/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Ratas Sprague-Dawley,
Sepsis/sangre,
Sepsis/patología,
Factor de Necrosis Tumoral alfa/sangre
AIMS: This study aimed to investigate the effects of crude extract of Carica papaya leaves on oxidative stress in mice induced by cyclophosphamide, as well as phytochemical profile characterization of this extract.
METHODS: The male Swiss mice received 15 days of treatment with the extract (500 mg kg-1, ...
ABSTRACT Objective Acrylamide is a potentially neurotoxic and carcinogenic chemical and naturally creates during the heating process of carbohydrate-rich foods, such as potato chips and breakfast cereals. Acrylamide might be ingested by people via consuming food that contains it. Therefore, we investiga...
Background: Mango (Mangifera indica L.) is one of the world’s most consumed fruit, and it is also a rich source of antioxidants that may prevent oxidative stress. Objectives: This study aimed to determine if mango (cv. Azúcar) juice can improve the antioxidant status of healthy individuals with low co...
Abstract Purpose: To investigate the therapeutic benefits of Hydroxysafflor yellow A (HSYA) on blood-brain barrier (BBB) vulnerability after traumatic brain injury (TBI) and identify its potential action of mechanisms on TBIinduced injuries. Methods: The rat TBI model was performed by using a controlle...
