Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the pro...
Momordica/química,
Extractos Vegetales/administración & dosificación,
Antioxidantes/administración & dosificación,
Ácido Valproico/toxicidad,
Testículo/efectos de los fármacos,
Ratas Wistar,
Inmunohistoquímica,
Western Blotting,
Receptores Androgénicos/efectos de los fármacos,
Fosfoproteínas,
Antígeno Ki-67
The environment is negatively affected by the increasing accumulation of both natural and man-made waste and by-products. Organophosphorous pesticides -malathion, diazinon and methamidophos- are used worldwide in pest control. The aim of this report is to review the effects of organophosphates on the mal...
The chemical constituents and insecticidal activity of essential oil obtained by hydrodistillation of the leaves of Paullinia pinnata Linn (Sapindaceae) are being reported. The essential oil were analysed by using gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS). Diff...
Extracts from leaves of C. sylvestris have cytotoxic effect in different tumor cell lines, possibly due to clerodane type diterpenes (casearins). On the other hand, there are few studies related to the antitumor activity of the essential oils from this species. This work evaluated for the first time the ...
INTRODUÇÃO: Desde a introdução do tratamento do HIV com uso da terapia antirretroviral altamente ativa, a mortalidade por essa doença foi reduzida drasticamente em todo o mundo. Um dos parefeitos relacionados à utilização desses fármacos é a lipodistrofia glútea. O objetivo deste trabalho é v...
VIH,
VIH/efectos de los fármacos,
Lipodistrofia/tratamiento farmacológico,
Lipodistrofia,
Síndrome de Lipodistrofia Asociada a VIH,
Síndrome de Lipodistrofia Asociada a VIH/tratamiento farmacológico,
Nalgas,
Nalgas/cirugía,
Infecciones por Retroviridae,
Infecciones por Retroviridae/tratamiento farmacológico,
Sistemas de Medicación,
Sistemas de Medicación/historia,
Calidad de Vida,
Anomalías Congénitas,
Anomalías Congénitas/cirugía,
Estudios de Cohortes,
Antirretrovirales,
Antirretrovirales/farmacología,
Antirretrovirales/análisis
Introdução: a constipação é uma doença crônica que afeta a população mundial, podendo ser consequência do desequilíbrio da microbiota intestinal, conhecida como disbiose. Nesse contexto, os probióticos vêm sendo utilizados com o objetivo de promover o seu equilíbrio, a fim de mantê-la saud...
Abstract Purpose: To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits. Methods: Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealan...
Abstract Purpose: To determine the effect of folic acid (FA) on experimental testicular ischemia/reperfusion (I/R) in rats. Methods: Sixty male Wistar rats were randomly divided into 6 groups. The control group received physiologic saline orally. The sham-operated group received physiologic saline oral...
Abstract Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subj...
Anacardiaceae/química,
Inductores de la Angiogénesis/uso terapéutico,
Colágeno/análisis,
Inmunohistoquímica,
Inflamación/tratamiento farmacológico,
Extractos Vegetales/uso terapéutico,
Hojas de la Planta/química,
Aceites de Plantas/uso terapéutico,
Tejido Subcutáneo/efectos de los fármacos,
Tejido Subcutáneo/patología,
Factores de Tiempo,
Cicatrización de Heridas/efectos de los fármacos
ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe th...
Anestésicos Disociativos/farmacología,
Conducta Animal/efectos de los fármacos,
Conducta Animal/fisiología,
Modelos Animales de Enfermedad,
Inmovilización/fisiología,
Ketamina/farmacología,
Actividad Motora/efectos de los fármacos,
Actividad Motora/fisiología,
Esquizofrenia/inducido químicamente,
Esquizofrenia/fisiopatología,
Natación/fisiología
