Abstract Purpose: To investigate the protective effect of L-carnitine on myocardial injury in rats with heatstroke. Methods: orty-eight rats were randomly divided into control, heatstroke and 25, 50 and 100 mg/kg L-carnitine groups. The last three groups were treated with 25, 50 and 100 mg/kg L-carniti...
Up to date, the management of hepatotoxicity induced by a suicidal or unintentional overdose of acetaminophen (APAP) remains a therapeutic challenge. The present study aimed to elucidate the potential effect of sitagliptin, a DPP-4 inhibitor, to ameliorate the acute injurious effects of acetaminophen on ...
Adverse changes occur gradually in the skeletal muscles with age via continuous exposure to oxidative stress. Quercetin, a member of the flavonoids family, possesses anti-oxidative and radical-scavenging activities. Therefore, this study investigated the role of quercetin to modulate age-induced changes ...
Abstract Purpose To evaluate the effect of remote ischemic conditioning associated to N-acetylcysteine (NAC) on testicular ischemia∕reperfusion (I∕R) injury in rats. Methods Twenty-five adult male Wistar rats were randomly distributed into five experimental groups (n=5), as follows: Sham,...
Acetilcisteína/farmacología,
Evaluación Preclínica de Medicamentos,
Depuradores de Radicales Libres/farmacología,
Precondicionamiento Isquémico/métodos,
Estrés Oxidativo/efectos de los fármacos,
Capacidad de Absorbancia de Radicales de Oxígeno,
Distribución Aleatoria,
Ratas Wistar,
Daño por Reperfusión,
Testículo/irrigación sanguínea,
Testículo/efectos de los fármacos
Vanadyl sulfate (VS) is an ingredient in some food supplements and experimental drugs. This study was designed to assay the effects of VS on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2. 30 male Wistar rats were divided into three equal groups as follow: no...
Biomarcadores/análisis,
Estrés Oxidativo/inmunología,
Diabetes Mellitus Tipo 2/patología,
Interleucina-1/antagonistas & inhibidores,
Interleucina-10/antagonistas & inhibidores,
Insulina/farmacología,
Preparaciones Farmacéuticas/administración & dosificación,
Secreción de Insulina,
Sulfatos/análisis,
Vanadatos/análisis,
Suplementos Dietéticos/efectos adversos
Abstract Aims: The purpose of the present study was to evaluate the effects of the resistance training (RT) on the lipid profile and metabolism, oxidative stress, and activity of metalloproteinase-2 (MMP-2) in the left ventricle (LV) of diet-induced obesity rats. Methods: Forty males Wistar rats 90 d...
RESUMO Objetivo O objetivo deste estudo foi investigar os efeitos agudos e crônicos da vareniclina no tecido pulmonar em um estudo experimental. Métodos Um total de 34 ratos foi alocado aleatoriamente em grupos de estudo (vareniclina) e controle. Assim, os ratos foram divididos em dois grupos: (i) gr...
Abstract Purpose To evaluate renal histological changes by stereology and morphometry and analyze the main markers of oxidative stress in rats undergoing natural aging. Methods Seventy two Wistar rats were divided into six groups of 12 rats each, which were euthanized at 3, 6, 9, 12, 18, and 24 months ...
Sabando, Constanza;
Rodríguez-Díaz, Maité;
Ide, Walther;
Pastene, Edgar;
Avello, Marcia;
Simirgiotis, Mario;
Rojas, Susana;
Villarroel, Enrique;
Silva-Grecchi, Tiare;
Gutiérrez, Cristian;
Bouza, Rebeca;
Cicchelli, Bárbara;
González, Marcelo;
Rodríguez-Llamazares, Saddys.
BACKGROUND: Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellagic acid and quercetin derivatives suggests its application to prevent endothelial...
INTRODUCCIÓN: Las alteraciones reproductivas de causa masculina relacionadas con el estrés oxidativo son cada día más estudiadas y dan cuenta de causas de infertilidad diagnosticada como idiopáticas. El objetivo del presente trabajo fue evaluar el efecto del zumo de sandía sobre los parámetros sem...
Espermatozoides/efectos de los fármacos,
Antioxidantes/farmacología,
Infertilidad Masculina,
Estrés Oxidativo,
Citrullus/química,
Jugos de Frutas y Vegetales,
Especies Reactivas de Oxígeno,
Extractos Vegetales/farmacología,
Licopeno,
Espermatozoides/metabolismo,
Motilidad Espermática,
Peróxido de Hidrógeno,
Semen
