El Departamento de Medicina Tropical del Instituto de Investigaciones en Ciencias de la Salud se dedicó desde sus inicios (1982) a la investigación de la Enfermedad de Chagas realizando estudios serológicos, búsqueda de un modelo animal y control de la enfermedad a través del mejoramiento de la vivi...
In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determi...
Bothrops lanceolatus venom contains a variety of enzymatic and biological activities. The present work investigated the hemolytic activity of this venom and its phospholipase A2 (PLA2). Bothrops lanceolatus venom (6.7 µg/mL) caused indirect hemolysis of cow, horse, rat and sheep erythrocytes, with horse...
Se realiza una revisión bibliográfica acerca de la historia y antecedentes históricos del consumo de la Catha edulis, Khat (Chat en amárico) en Etiopía (hoy Eritrea), un análisis botánico-farmacológico de sus componentes químicos y sus efectos sobre el organismo humano, tanto del punto de vista ...
Plinia edulis (Myrtaceae), espécie arbórea popularmente conhecida como cambucá, é nativa da Mata Atlântica brasileira. Apesar do emprego na medicina tradicional em diversas moléstias, incluindo distúrbios gástricos, não existem estudos relacionando as atividades biológicas e os constituintes qu...
O estresse oxidativo produzido no organismo relaciona-se com o aparecimento e/ou desenvolvimento de uma série de doenças crônico-não transmissíveis. Os compostos fenólicos, presentes nos vegetais, são capazes de neutralizar as estruturas radicalares; diminuindo, portanto, o risco de surgimento de ...
Since 1987, when chemopreventive testing programs began, more than 1,000 agents and agent combinations have been selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers. In the present study we aimed to provide quantitative and qualitative characterizati...
Os depoimentos apresentam a história do Núcleo de Pesquisas de Produtos Naturais da Universidade Federal do Rio de Janeiro, criado em 1963 após a extinção do Instituto de Química Agrícola, do Ministério da Agricultura. Decorridos quase cinqüenta anos, dois dos remanescentes do antigo instituto c...
Red scorpion (Mesobuthus tamulus or Buthus tamulus) venom samples were collected at different regions of India: western (Chiplun and Ahmednagar from Maharashtra State) and southern (Ratnagiri and Chennai from Tamil Nadu State). The action of whole venoms on the blood sodium levels of mice was assessed us...
Interleukin-15 (IL-15) is a pleiotropic cytokine which regulates the proliferation, survival and the secretory activities of many distinct cell types in the body. This cytokine is produced by macrophages and many other cell types in response to infectious agents; it controls growth and differentiation of...
