ABSTRACT A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out o...
Amidinas/síntesis química,
Amidinas/farmacología,
Antiinfecciosos/síntesis química,
Antiinfecciosos/farmacología,
Candida albicans/efectos de los fármacos,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Bacterias Gramnegativas/efectos de los fármacos,
Ensayo de Materiales,
Pruebas de Sensibilidad Microbiana,
Reproducibilidad de los Resultados,
Espectrofotometría Infrarroja,
Sales de Tetrazolio,
Tiazoles,
Pruebas de Toxicidad
ABSTRACT Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) ...
Acetilcolinesterasa/análisis,
Acetilcolinesterasa/efectos de los fármacos,
Acetilcolinesterasa/fisiología,
Antioxidantes/farmacología,
Ácido Ascórbico/farmacología,
Cuerpo Estriado/efectos de los fármacos,
Cuerpo Estriado/enzimología,
Suplementos Dietéticos,
Modelos Animales de Enfermedad,
Antagonistas de Aminoácidos Excitadores,
Hipocampo/efectos de los fármacos,
Hipocampo/enzimología,
Ketamina,
Locomoción/efectos de los fármacos,
Locomoción/fisiología,
Esquizofrenia/enzimología,
Esquizofrenia/prevención & control
ABSTRACT The gill mitochondria-rich cells of the juvenile Amazonian fish Colossoma macropomum were analyzed using light and scanning and transmission electron microscopy after 96 h exposure to 0.04 and 0.2 mM nitrite. Although the number of mitochondria-rich cells decreased significantly in the lamellar ...
BISPO, VANDERSON S;
DANTAS, LUCAS S;
CHAVES FILHO, ADRIANO B;
PINTO, ISABELLA F D;
SILVA, RAILMARA P DA;
OTSUKA, FELIPE A M;
SANTOS, RODRIGO B;
SANTOS, ALINE C;
TRINDADE, DANIELLE J;
MATOS, HUMBERTO R.
ABSTRACT Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI+-MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective ...
Antioxidantes/farmacología,
Ácido Ascórbico/farmacología,
Ácidos Cafeicos/farmacología,
Colesterol/sangre,
Cocos/química,
Daño del ADN/efectos de los fármacos,
Etanol/farmacología,
Peroxidación de Lípido,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados,
Espectrometría de Masas en Tándem,
Sustancias Reactivas al Ácido Tiobarbitúrico,
Factores de Tiempo,
Triglicéridos/sangre,
Agua/farmacología
ABSTRACT Phoradendron mucronatum and P. microphyllum are plants that found in tropical and subtropical areas, used in traditional medicine and popularly known as mistle-thrush. The aim of this study was to identify the chemical constituents of different leaf extracts from P. mucronatum and P. microphyllu...
Acetatos/química,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Cloroformo/química,
Cromatografía de Gases y Espectrometría de Masas,
Hexanos/química,
Células MCF-7,
Cloruro de Metileno/química,
Phoradendron/química,
Extractos Vegetales/química,
Extractos Vegetales/farmacología,
Hojas de la Planta/química,
Reproducibilidad de los Resultados,
Sales de Tetrazolio,
Tiazoles,
Pruebas de Toxicidad,
Viscaceae/química
Abstract Plants respond to wounding caused by mechanical stress or herbivory by synthesizing defense proteins. There are no studies reporting the action of induced plant proteins against ticks. The aim of this study was to investigate the effect of mechanically wounded Leucaena leucocephala leaves agains...
Abstract The distinction between healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) infections has become increasingly blurred. We assessed the molecular characterization and antimicrobial resistance profile for MRSA isolates from blood. Most of all (81.9%) isolates are related ...
Abstract Meat is one of the most perishable foods owing to its nutrient availability, high water activity, and pH around 5.6. These properties are highly conducive for microbial growth. Fresh meat, when exposed to oxygen, is subjected to the action of aerobic psychrotrophic, proteolytic, and lipolytic sp...
ABSTRACT Objective: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations. ...
Antibióticos Antituberculosos/efectos adversos,
Audiometría de Tonos Puros/métodos,
Umbral Auditivo/efectos de los fármacos,
Umbral Auditivo/fisiología,
Pérdida Auditiva/inducido químicamente,
Pérdida Auditiva/fisiopatología,
Estudios Prospectivos,
Valores de Referencia,
Índice de Severidad de la Enfermedad,
Factores Sexuales,
Factores de Tiempo,
Insuficiencia del Tratamiento,
Tuberculosis Resistente a Múltiples Medicamentos/complicaciones,
Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico,
Tuberculosis Resistente a Múltiples Medicamentos/fisiopatología
ABSTRACT Objective: To evaluate the effects of exposure to emissions from sugar cane burning on inflammatory mechanisms in tissues of the trachea and lung parenchyma in Wistar rats after different periods of exposure. Methods: This was an experimental open randomized study. The animals were divided int...
Contaminantes Atmosféricos/toxicidad,
Colágeno/análisis,
Incineración,
Exposición por Inhalación/efectos adversos,
Pulmón/efectos de los fármacos,
Pulmón/patología,
Modelos Animales,
Distribución Aleatoria,
Ratas Wistar,
Factores de Riesgo,
Saccharum,
Humo/efectos adversos,
Factores de Tiempo,
Tráquea/efectos de los fármacos,
Tráquea/patología
