Abstract Objectives To investigate the effect of a standardized extract of Centella asiatica (ECa 233), which has anti-inflammatory properties, on the local expression of the transient receptor potential vanilloid 1 (TRPV1), the acid-sensing ion channel subunit 3 (ASIC3), and the calcitonin gene-relate...
BACKGROUND: The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous extract at low temperature (0 °C) mediated mitochondrial fission contributed to in...
Juniperus communis (JCo) is a well-known traditional Chinese medicinal plant that has been used to treat wounds, fever, swelling, and rheumatism. However, the mechanism underlying the anticancer effect of JCo extract on colorectal cancer (CRC) has not yet been elucidated. This study investigated the anti...
Adenocarcinoma/tratamiento farmacológico,
Antineoplásicos Fitogénicos/farmacología,
Apoptosis,
Ciclo Celular,
Puntos de Control del Ciclo Celular,
Línea Celular Tumoral,
Proliferación Celular,
Neoplasias Colorrectales/tratamiento farmacológico,
Juniperus,
Ratones Endogámicos BALB C,
Extractos Vegetales/farmacología
Sousa, A P;
Oliveira, M S;
Fernandes, D A;
Ferreira, M D L;
Cordeiro, L V;
Souza, M F V;
Fernandes, L M D;
Souza, H D S;
Oliveira Filho, A A;
Pessoa, H L F;
Sá, R C S.
Phytochemical studies of the species Pavonia glazioviana were performed. Quercetin, kaempferol, acacetin, and trimethoxylated flavonoid compounds (which present biological activity) were isolated. We aimed to evaluate the in silico, in vitro, and ex vivo toxicity of flavonoid 5,7-dihydroxy-3,8,4'-trimeth...
Medeiros, Scheila;
Maia, Thayná Patachini;
Lima, Aline Barbosa;
Pscheidt, Luana Carla;
Delmonego, Larissa;
Vincenzi, Karine Louize;
Custodio, Bruna Vanzin;
Dal Magro, Débora Delwing;
Barauna, Sara Cristiane;
Alberton, Michele Debiasi;
Pereira, Eduardo Manoel;
Delwing-de Lima, Daniela.
We investigated the effects of dichloromethane extract (DME) from Myrcia splendenson alterations caused by type 2 diabetes in the blood and kidney of rats, in order to reduce side effects caused by synthetic drugs. Rats received streptozotocin (60 mg/kg),15 minutes after nicotinamide (120 mg/kg) or water...
Myrtaceae/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Extractos Vegetales/administración & dosificación,
Cloruro de Metileno/administración & dosificación,
Hipolipemiantes/administración & dosificación,
Hipoglucemiantes/administración & dosificación,
Antioxidantes/administración & dosificación,
Extractos Vegetales/química,
Compuestos Fenólicos/análisis,
Estrés Oxidativo/efectos de los fármacos,
Cromatografía Líquida de Alta Presión,
Espectrometría de Masa por Ionización de Electrospray,
Ratas Wistar,
Glucemia/efectos de los fármacos,
Estreptozocina
Santos, Débora Silva;
Moura, Ludmilla David de;
Radicchi, Marina Arantes;
Azevedo, Ricardo Bentes;
Costa, Maria Célia Pires;
Souza, Paulo Eduardo Narcizo de;
Camara, Adriana Leandro;
Silva, Jaqueline Rodrigues da;
Muehlmann, Luís Alexandre;
Longo, João Paulo Figueiró.
HIGHLIGHTS Production of lipid nanoemulsions (<100 nm) of industrial interest with low energy demand. The antioxidant properties of babassu oil have been improved and the nanoemulsions are not cytotoxic. Babassu oil is a food and medicinal product. The nanoemulsion is strategic for the developed...
HIGHLIGHTS Essential oils from populations of B. dracunculifolia were investigated. β-pinene and (E)-nerolidol were the main compounds in B. dracunculifolia populations. The difference in the chemical profile of the essential oils is quantitative only. There is a negative correlation between t...
Hamadou, Meriem Hadjer;
Kerkatou, Messaoud;
Zucal, Chiara;
Bisio, Alessandra;
Provenzani, Alessandro;
Inga, Alberto;
Menad, Ahmed;
Benayache, Samir;
Benayache, Fadila;
Ameddah, Souad.
HIGHLIGHTS L. duriusculum n-BuOH extract reduces inflammatory responses both in vitro and in vivo. L. duriusculum n-BuOH extract inhibits NF-κB-dependent transcriptional responses. L. duriusculum n-BuOH extract decreases the expression of TNF-α and IL-6 genes....
HIGHLIGHTS Isolate, fractionate and characterize extracts obtained from soursop leaves. Use of emerging green technologies such as microwave-ultrasound hybridization. The extracts contain kaempferol, procyanidins, catechin, and quercetin. The total ethanolic extract demonstrates cytotoxic effect on...
HIGHLIGHTS The phenolic composition, antioxidant activity and cytotoxic potential of the extracts of C. solstitialis and U. picroides were investigated. Caffeic acid was found as the most abundant phenolic compound in the extracts. Both species showed promising antioxidant activity towards different...
Antioxidantes/farmacología,
Asteraceae/química,
Centaurea/química,
Compuestos Fenólicos/análisis,
Ácidos Cafeicos/farmacología,
Fenoles/farmacología,
Extractos Vegetales/farmacología,
Cromatografía Líquida de Alta Presión,
Turquía,
Plantas Medicinales,
Citotoxinas/farmacología,
Células HEK293
