Abstract INTRODUCTION: The present study investigated the association of the rs2794521 polymorphism in the CRP gene in individuals with chronic hepatitis B and C, correlating it with markers of hepatic inflammation, fibrosis scores, viral load, and plasma protein levels. METHODS: The study analyzed 185...
Biomarcadores/sangre,
Proteína C-Reactiva/análisis,
Proteína C-Reactiva/genética,
Estudios de Casos y Controles,
Estudios Transversales,
Genotipo,
Hepatitis B Crónica/sangre,
Hepatitis B Crónica/genética,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/genética,
Cirrosis Hepática/sangre,
Cirrosis Hepática/virología,
Índice de Severidad de la Enfermedad,
Carga Viral
Abstract We report the first case of cryptococcosis due to Cryptococcus decagattii in an immunocompetent pediatric patient from an indigenous community in Argentina with a successful outcome. Two isolates (blood, cerebrospinal fluid) were genotyped by restriction fragment length polymorphism of the oroti...
Abstract Heart transplantation is an effective treatment for Chagas disease patients with severe cardiomyopathy. However, Trypanosoma cruzi reactivation is of great concern. The T. cruzi parasite is classified into six discrete typing units (DTUs identified as TcI-TcVI). It is unknown whether there is an...
Cardiomiopatía Chagásica/tratamiento farmacológico,
Cardiomiopatía Chagásica/cirugía,
ADN Protozoario,
Variación Genética,
Genotipo,
Trasplante de Corazón/efectos adversos,
Inmunosupresores/uso terapéutico,
Persona de Mediana Edad,
Nitroimidazoles/uso terapéutico,
Reacción en Cadena de la Polimerasa,
Tripanocidas/uso terapéutico
BACKGROUND Hepatitis delta virus (HDV) infections in hepatitis B virus (HBV) carriers are the most severe form of viral hepatitis. HDV prevalence is high in the Brazilian Amazon, but studies in other regions of the country are still scarce and often underestimated its prevalence by including a small numb...
Recurrent hepatitis C (HCV) after liver transplantation (LT) is an important cause of morbidity and mortality. Antiviral treatment is recommended to avoid unfavorable outcomes. Direct-acting antivirals (DAA) have transformed HCV treatment, with higher efficacy and fewer side-effects than interferon-based...
Antivirales/administración & dosificación,
Quimioterapia Combinada,
Genotipo,
Hepatitis C/tratamiento farmacológico,
Imidazoles/administración & dosificación,
Trasplante de Hígado/efectos adversos,
Recurrencia,
Estudios Retrospectivos,
Ribavirina/administración & dosificación,
Sofosbuvir/administración & dosificación,
Respuesta Virológica Sostenida,
Resultado del Tratamiento,
Carga Viral
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were re...
ABSTRACT Objective To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays. Methods A total of one thousand samples were tested through quantitative analysis of enzyme activity, detecting 25 G6PD-deficient individuals. Patie...
ABSTRACT Objective To described the allele and haplotype frequencies of human leukocyte antigen genes at the -A, -B loci and human platelet antigen genes for human platelet antigen systems 1 to 9, 11 and 15 in blood. Methods We included 867 healthy unrelated volunteer donors who donated platelets bet...
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cogn...
Enfermedad de Alzheimer/complicaciones,
Factor Neurotrófico Derivado del Encéfalo/genética,
Estudios de Casos y Controles,
Disfunción Cognitiva/complicaciones,
Disfunción Cognitiva/genética,
Población Blanca,
Predisposición Genética a la Enfermedad,
Genotipo,
Oportunidad Relativa,
Enfermedad de Parkinson/complicaciones,
Enfermedad de Parkinson/genética,
Polimorfismo de Nucleótido Simple,
Factores de Riesgo
A deficiência da biotinidase (DB) é doença metabólica hereditária, autossômica recessiva, causada por mutações no gene da biotinidase (BTD), localizado no cromossomo 3. Apresenta expressão fenotípica diversa em razão de deficiência variável da atividade da enzima biotinidase. Se não diagnos...
