Objetivo: o objetivo do presente estudo foi avaliar a ação antimicrobiana do hipoclorito de sódio a 1%, da clorexidina a 2% e do EDTA a 24% — todos na forma de gel —, sobre o biofilme oral. Métodos: blocos de dentina bovina estéreis foram inseridos em um dispositivo intrabucal, o qual foi utiliz...
The aim of this study was to evaluate efficacy and safety of amfepramone, fenproporex and mazindol as a monotherapy for the treatment of obese or overweight patients. A systematic review of primary studies was conducted, followed by a direct meta-analysis (random effect) and mixed treatment comparison. M...
Depresores del Apetito/metabolismo,
Depresores del Apetito/uso terapéutico,
Dietilpropión/metabolismo,
Dietilpropión/uso terapéutico,
Mazindol/metabolismo,
Mazindol/uso terapéutico,
Obesidad/tratamiento farmacológico,
Obesidad/metabolismo,
Sobrepeso/tratamiento farmacológico,
Sobrepeso/metabolismo,
Sesgo de Publicación,
Reproducibilidad de los Resultados,
Factores de Riesgo,
Resultado del Tratamiento,
Pérdida de Peso/efectos de los fármacos
ABSTRACT The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strateg...
PAIVA, DERISVALDO R;
LIMA, DÊNIS P DE;
AVVARI, NAGA P;
ARRUDA, EDUARDO J DE;
CABRINI, ISAIAS;
MARQUES, MARIA RITA;
SANTOS, EDSON A DOS;
BIAGGIO, FRANCISCO C;
SANGI, DIEGO P;
BEATRIZ, ADILSON.
ABSTRACT Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. The isolation of cardanol is somewhat troublesome, however, in this work we describe an efficient and inexpensive method to obtain it as a pure material. The compound was used as startin...
Aedes/efectos de los fármacos,
Insecticidas/síntesis química,
Insecticidas/farmacología,
Insecticidas/toxicidad,
Larva/efectos de los fármacos,
Dosificación Letal Mediana,
Fenoles/química,
Fenoles/aislamiento & purificación,
Fenoles/farmacología,
Fenoles/toxicidad,
Factores de Tiempo
ABSTRACT Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2 •- scavenging (IC50 = 27.44 ± 0.09) than those of litchi an...
Administración Cutánea,
Antioxidantes/aislamiento & purificación,
Antioxidantes/farmacología,
Cosméticos,
Fibroblastos/efectos de los fármacos,
Depuradores de Radicales Libres/farmacología,
Frutas/química,
Litchi/química,
Fenoles/farmacología,
Extractos Vegetales/farmacología,
Sapindaceae/química,
Envejecimiento de la Piel/efectos de los fármacos,
Tamarindus/química
ABSTRACT This study aimed to identify the 516 G>T polymorphism of the CYP2B6 gene and evaluate its influence on central nervous system (CNS) side effect development in HIV-positive individuals undergoing Efavirenz (EFV) treatment in a population from southern Brazil. Additionally, we performed a surve...
Benzoxazinas/efectos adversos,
Benzoxazinas/uso terapéutico,
Relación CD4-CD8,
Sistema Nervioso Central/efectos de los fármacos,
Citocromo P-450 CYP2B6/genética,
Genotipo,
Infecciones por VIH/tratamiento farmacológico,
Infecciones por VIH/genética,
Polimorfismo Genético/genética,
Estudios Prospectivos,
Inhibidores de la Transcriptasa Inversa/efectos adversos,
Inhibidores de la Transcriptasa Inversa/uso terapéutico,
Carga Viral
ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-am...
Analgésicos/farmacología,
Antioxidantes/farmacología,
Modelos Animales de Enfermedad,
Depuradores de Radicales Libres,
Oxidación-Reducción,
Estrés Oxidativo/efectos de los fármacos,
Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro/farmacología,
Dimensión del Dolor,
Porfobilinógeno Sintasa/farmacología,
Quinolinas/química,
Quinolinas/farmacología,
Selenio/farmacología
ABSTRACT Both the scientific community and society have shown interest in improving the content of amino acids, carbohydrates and mineral nutrients in maize because it represents an important staple food in many developing countries. Earlier studies demonstrated that the treatment of seeds using ascorbic...
KWON, DA HYE;
JEONG, JIN WOO;
CHOI, EUN OK;
LEE, HYE WON;
LEE, KI WON;
KIM, KI YOUNG;
KIM, SUNG GOO;
HONG, SU HYUN;
KIM, GI-YOUNG;
PARK, CHEOL;
HWANG, HYE-JIN;
SON, CHANG-GUE;
CHOI, YUNG HYUN.
ABSTRACT Mori folium, the leaf of Morus alba L. (Moraceae), has been traditionally used for various medicinal purposes from ancient times to the present. In this study, we examined the effects of water extract of Mori folium (WEMF) on the production of inflammatory mediators, such as nitric oxide (NO) an...
Expresión Génica,
Genes Reguladores,
Mediadores de Inflamación/antagonistas & inhibidores,
Mediadores de Inflamación/metabolismo,
Lipopolisacáridos,
Macrófagos/efectos de los fármacos,
Macrófagos/metabolismo,
Morus/química,
Óxido Nítrico/metabolismo,
Extractos Vegetales/farmacología,
Prostaglandinas E/metabolismo,
Células RAW 264.7,
Especies Reactivas de Oxígeno/antagonistas & inhibidores,
Pez Cebra
ABSTRACT The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (M...
Embrión de Mamíferos/anomalías,
Embrión de Mamíferos/efectos de los fármacos,
Desarrollo Embrionario/efectos de los fármacos,
Metilnitrosourea/toxicidad,
Ratones Endogámicos DBA,
Esqueleto/anomalías,
Esqueleto/efectos de los fármacos,
Esqueleto/embriología,
Somitos/anomalías,
Somitos/efectos de los fármacos,
Somitos/embriología,
Teratógenos/toxicidad
