Abstract Background: The high cardiotoxicity morbidity and mortality rates associated with the antineoplastic therapy for breast cancer could be reduced with the early use of cardioprotective drugs. However, the low sensitivity of left ventricular ejection fraction limits its use in that preventive stra...
Antraciclinas/efectos adversos,
Antineoplásicos/efectos adversos,
Brasil/epidemiología,
Neoplasias de la Mama/tratamiento farmacológico,
Cardiotoxicidad/diagnóstico,
Cardiotoxicidad/epidemiología,
Cardiotoxicidad/etiología,
Diagnóstico Precoz,
Ecocardiografía Doppler,
Estudios de Seguimiento,
Cardiopatías/inducido químicamente,
Cardiopatías/diagnóstico por imagen,
Ventrículos Cardíacos/diagnóstico por imagen,
Incidencia,
Estudios Prospectivos,
Análisis de Regresión,
Trastuzumab/efectos adversos,
Función Ventricular Izquierda/efectos de los fármacos
Hameau, René;
Gabrielli, Luigi;
Garrido, Marcelo;
Guzmán, Ana María;
Retamal, Ignacio;
Vacarezza, María José;
Greig, Douglas;
Ocqueteau, Mauricio;
Sánchez, César;
Pizarro, Marcela;
Corvalán, Alejandro;
Lavandero, Sergio;
Castro, Pablo F;
Martínez, Gonzalo.
Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, these new therapies, along with greater patient survival, are associated with an increase in untoward effects, particularly in the cardiovas...
Antineoplásicos/efectos adversos,
Cardiotoxicidad/etiología,
Cardiotoxicidad/prevención & control,
Enfermedades Cardiovasculares/etiología,
Enfermedades Cardiovasculares/prevención & control,
Radioterapia/efectos adversos,
Antineoplásicos/clasificación,
Biomarcadores,
Neoplasias/complicaciones,
Neoplasias/tratamiento farmacológico,
Desarrollo de Programa,
Factores de Riesgo
O osteossarcoma (OS) é o tumor maligno primário mais comum do tecido ósseo, caracterizado pela formação de osteócitos anormais. Apesar do avanço nas terapias convencionais (quimioterapia e retirada do tumor), essas não conseguem eliminar totalmente as células tumorais e impedir a progressão da ...
Acetofenonas/farmacología,
Compuestos de Bifenilo/farmacología,
Antineoplásicos/farmacología,
Osteosarcoma/tratamiento farmacológico,
Osteoblastos/efectos de los fármacos,
Células Tumorales Cultivadas,
Supervivencia Celular/efectos de los fármacos,
Especies Reactivas de Oxígeno/análisis,
Apoptosis/efectos de los fármacos,
Metaloproteinasa 2 de la Matriz/efectos de los fármacos,
Metaloproteinasa 9 de la Matriz/efectos de los fármacos,
Movimiento Celular/efectos de los fármacos,
Reproducibilidad de los Resultados
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because t...
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiothe...
OBJECTIVE: To correlate the perceptions related to dietary intake with the domains and subscales of health-related quality of life (HRQL) in women with breast neoplasms receiving chemotherapy. METHODS: In this prospective study, 55 women with breast cancer were followed up during chemotherapy at three d...
Análisis de Varianza,
Antineoplásicos/efectos adversos,
Apetito/efectos de los fármacos,
Neoplasias de la Mama/tratamiento farmacológico,
Neoplasias de la Mama/psicología,
Carcinoma Ductal de Mama/tratamiento farmacológico,
Carcinoma Ductal de Mama/psicología,
Carcinoma Lobular/tratamiento farmacológico,
Carcinoma Lobular/psicología,
Preferencias Alimentarias/efectos de los fármacos,
Preferencias Alimentarias/psicología,
Percepción/efectos de los fármacos,
Estudios Prospectivos,
Calidad de Vida/psicología,
Valores de Referencia,
Estadísticas no Paramétricas,
Factores de Tiempo
OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patients in the Department of Gastrointestinal Oncology at Z...
Antineoplásicos/uso terapéutico,
Estudios de Casos y Controles,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/genética,
Neoplasias Colorrectales/mortalidad,
Proteínas de Unión al ADN/genética,
Endonucleasas/genética,
Genotipo,
Estimación de Kaplan-Meier,
Estadificación de Neoplasias,
Proteínas Nucleares/genética,
Oxaliplatino/uso terapéutico,
Polimorfismo de Nucleótido Simple/genética,
Factores de Transcripción/genética
Osteosarcoma (OS) has a high incidence, malignity, and frequency of recurrence and metastasis. In this study, we aimed to explore the potential anti-cancer effects of Astragalus polysaccharides (APS) on human OS MG63 cells as well as underlying mechanisms. Viability of MG63 cells was assessed by CCK-8 as...
Análisis de Varianza,
Antineoplásicos/farmacología,
Apoptosis/efectos de los fármacos,
Planta del Astrágalo/química,
Western Blotting,
Neoplasias Óseas/tratamiento farmacológico,
Neoplasias Óseas/patología,
Ciclo Celular/efectos de los fármacos,
Línea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Proteínas Quinasas JNK Activadas por Mitógenos/análisis,
MicroARNs/análisis,
Reproducibilidad de los Resultados,
Regulación hacia Arriba/efectos de los fármacos
The tumor suppressive role of oridonin, an active compound extracted from Rabdosia rubescens, has been proven in several gastric cancer (GC) cell lines. The present study aimed to evaluate the effect of oridonin on another GC cell line, SNU-216, and explore the potential mechanisms. The viable cell numbe...
Antineoplásicos/farmacología,
Apoptosis/efectos de los fármacos,
Western Blotting,
Carcinoma/tratamiento farmacológico,
Carcinoma/metabolismo,
Carcinoma/patología,
Caspasa 3/análisis,
Caspasa 9/análisis,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Daño del ADN/efectos de los fármacos,
Diterpenos de Tipo Kaurano/farmacología,
Citometría de Flujo,
Células HEK293,
Reproducibilidad de los Resultados,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Neoplasias Gástricas/tratamiento farmacológico,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Proteína p53 Supresora de Tumor/análisis
ABSTRACT This review aimed to analyze the scientific production on severity of oral mucositis as an adverse effect of chemotherapy. To this end, we performed a search at PubMed databases combining the keywords "oral mucositis" and "chemotherapy protocol". To describe the investigation, the following vari...
